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Methyl 6-carbamoylpicolinate is a carbamoylpyridine derivative, a white to light yellow crystalline solid that is soluble in organic solvents. It is a versatile compound with carbamoyl and carboxylic acid functional groups, primarily used as an intermediate in the manufacturing of pharmaceuticals, agrochemicals, and other organic compounds. Additionally, it serves as a building block in the synthesis of various biologically active molecules.

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  • 108129-47-1 Structure
  • Basic information

    1. Product Name: methyl 6-carbamoylpicolinate
    2. Synonyms: methyl 6-carbamoylpicolinate
    3. CAS NO:108129-47-1
    4. Molecular Formula: C8H8N2O3
    5. Molecular Weight: 180.16072
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 108129-47-1.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: methyl 6-carbamoylpicolinate(CAS DataBase Reference)
    10. NIST Chemistry Reference: methyl 6-carbamoylpicolinate(108129-47-1)
    11. EPA Substance Registry System: methyl 6-carbamoylpicolinate(108129-47-1)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 108129-47-1(Hazardous Substances Data)

108129-47-1 Usage

Uses

Used in Pharmaceutical Industry:
Methyl 6-carbamoylpicolinate is used as an intermediate for the synthesis of pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, methyl 6-carbamoylpicolinate is utilized as an intermediate in the production of agrochemicals, aiding in the creation of effective crop protection products.
Used in Organic Synthesis:
Methyl 6-carbamoylpicolinate is employed as a building block in organic synthesis, enabling the development of a wide range of biologically active molecules with potential applications in various fields.
It is crucial to handle methyl 6-carbamoylpicolinate with care and adhere to safety protocols when working with it in laboratory settings to ensure the safety of researchers and the integrity of experiments.

Check Digit Verification of cas no

The CAS Registry Mumber 108129-47-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,1,2 and 9 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 108129-47:
(8*1)+(7*0)+(6*8)+(5*1)+(4*2)+(3*9)+(2*4)+(1*7)=111
111 % 10 = 1
So 108129-47-1 is a valid CAS Registry Number.

108129-47-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name Methyl 6-carbamoylpicolinate

1.2 Other means of identification

Product number -
Other names methyl 6-carbamoylpyridine-2-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:108129-47-1 SDS

108129-47-1Relevant articles and documents

Self-assembly of a trinuclear luminescent Europium complex

Zebret, Soumaila,Dupont, Nathalie,Bernardinelli, Gerald,Hamacek, Josef

, p. 3355 - 3358 (2009)

A study was conducted to demonstrate the self-assembly of a trinuclear luminescent europium complex. The study also involved preparation, structure, and characterization of the europium complex with bis(6-carboxypyridine-2- carbonyl)amine. It was observed

DOPAMINE D3 RECEPTOR ANTAGONISTS COMPOUNDS

-

Page/Page column 109, (2016/05/19)

The disclosure is directed to novel dopamine D3 receptor antagonists, processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, including treating drug dependency and psychosis.

Synthesis of primary amides by aminocarbonylation of aryl/hetero halides using non-gaseous NH3 and CO sources

Suresh,Baburajan, Poongavanam,Ahmed, Mansur

supporting information, p. 4864 - 4867 (2015/07/28)

Abstract A practically simple method for the synthesis of primary amides via the palladium-catalysed aminocarbonylation of aromatic halides by using solid sources of gaseous ammonia and carbon monoxide is described. The system tolerated a wide variety of hindered and functionalized aryl/hetero halides and afforded good to excellent yields (69-94%) of the amide. Pharmacologically active Exalamide and Pyrazinecarboxamide were synthesised in high yields to demonstrate the effectiveness of this method.

Synthesis, crystal structure, and different local conformations of pyridine-imide oligomers

Zhu, Hengheng,He, Weiwei,Zhan, Chuanlang,Li, Xiao,Guan, Zisheng,Guo, Fengqi,Yao, Jiannian

experimental part, p. 8458 - 8464 (2011/11/13)

In this article, we report a new approach toward synthesis of pyridine-imide oligomers (PIOs). Using this approach, both dimer and trimer were one-pot synthesized from acylation of monomeric monoamide with monomeric dichloride. The yield of trimer was dependent on the alkoxyl terminals: it was 30% for methoyl group, whereas it was 95% for 3-chloro-1-propoxyl terminal. Acylation of dimeric monoamide with monomeric dichloride produced trimer, tetramer, and pentamer in a yield of 34%, 33%, and 28%, respectively. The synthesis was proposed to be mediated through an exchange between pyridine-2-carboxamide and pyridine-2-carbonyl chloride, both forming intramolecular or intermolecular hydrogen-bonds between pyridine-nitrogen and pyridine-2-amide hydrogen atoms. Crystal structure from three trimers with different terminal groups was reported. Analysis on the crystal structures revealed that these three trimers had different local conformations. The different local conformations were originated from the structural tunability of the imide unit in either the coplanarity or bond parameters.

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