methyl 6-carbamoylpicolinate

Base Information

• Chemical Name: methyl 6-carbamoylpicolinate
• CAS No.: 108129-47-1
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.163
• Hs Code.: 2933399090
• Mol file: 108129-47-1.mol

Synonyms:methyl 6-carbamoylpicolinate

Chemical Property of methyl 6-carbamoylpicolinate

Chemical Property:

• PSA: 82.28000
• LogP: 0.66740
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl6-carbamoylpicolinate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 6-carbamoylpicolinate

There total 8 articles about methyl 6-carbamoylpicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

methyl 6-Bromopicolinate (26218-75-7) + dicobalt octacarbonyl (15226-74-1,61091-28-9,61117-58-6) → methyl 6-carbamoylpyridine-2-carboxylate (108129-47-1)

Guidance literature:

With 1H-imidazole; 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 90 ℃; for 3h; Sealed tube;

DOI:10.1016/j.tetlet.2015.06.054

Reference yield: 50.0%

6-(methoxycarbonyl)pyridine-2-carboxylic acid (7170-36-7) → methyl 6-carbamoylpyridine-2-carboxylate (108129-47-1)

Guidance literature:

With silica gel; ammonium chloride; triethylamine; p-toluenesulfonyl chloride; In dichloromethane;

DOI:10.1002/chem.200802676

Reference yield:

methyl 6-(1H-1,2,3-benzotriazole-1-carbonyl)pyridine-2-carboxylate → methyl 6-carbamoylpyridine-2-carboxylate (108129-47-1)

Guidance literature:

With ammonium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

6-(methoxycarbonyl)pyridine-2-carboxylic acid

2-(n-propoxycarbonyl)-pyridine-6-carboxamide

methyl 6-(chlorocarbonyl)picolinate

2,6-Pyridinedicarbonyl dichloride

Downstream raw materials:

Pyridin-2-carbonsaeure-6-carbonsaeureamid