1082040-45-6

Basic information

• Product Name: 5-Bromo-3-methoxy-2-methylaniline
• Synonyms: 5-Bromo-3-methoxy-2-methylaniline;5-Bromo-3-methoxy-2-methylanilin;3-bromo-5-methoxy-2-methylbenzenamine
• CAS NO: 1082040-45-6
• Molecular Formula: C₈H₁₀BrNO
• Molecular Weight: 216.0751
• Mol File: 1082040-45-6.mol

Chemical Properties

• Boiling Point: 294.2±35.0 °C(Predicted)
• Appearance: /
• Density: 1.458±0.06 g/cm3(Predicted)
• PKA: 2.96±0.10(Predicted)
• CAS DataBase Reference: 5-Bromo-3-methoxy-2-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-3-methoxy-2-methylaniline(1082040-45-6)
• EPA Substance Registry System: 5-Bromo-3-methoxy-2-methylaniline(1082040-45-6)

Safety Data

• Hazardous Substances Data: 1082040-45-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromo-3-methoxy-2-methylaniline is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Bromo-3-methoxy-2-methylaniline serves as an intermediate in the production of agrochemicals. Its properties make it suitable for the creation of compounds that can be used in agricultural applications, such as pesticides and herbicides, to enhance crop protection and yield.
Used in Dye and Pigment Production:
5-Bromo-3-methoxy-2-methylaniline is utilized in the manufacturing process of dyes and pigments. Its chemical structure imparts color and stability, making it a valuable component in the formulation of a wide range of colorants used in various industries, including textiles, plastics, and printing inks.
Used in Research and Development:
5-Bromo-3-methoxy-2-methylaniline is also used in research and development settings for the exploration of new chemical reactions and the creation of novel compounds. Its presence in the scientific community aids in the discovery of new applications and improvements in existing technologies.

Upstream product

• 885519-07-3 5-bromo-1-methoxy-2-methyl-3-nitrobenzene 

Downstream Products

• 885519-21-1 6-bromo-4-methoxy-1H-indazole 

Relevant articles and documents

Compounds and Compositions as Protein Kinase Inhibitors

The present invention provides compounds of Formula I or II: wherein R1, R1b, R2, R3, R4, R5, R6 and R7 are defined herein. The compounds of Formula (I) or (II) and pharmaceutical compositions thereof are useful for the treatment of B-Raf-associated diseases.

COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.

2-AMINOQUINAZOLINE DERIVATIVE

An object of the present invention is to provide compounds which are useful as protein kinase inhibitors. Disclosed is a 2-aminoquinazoline derivative represented by the following formula (I): wherein R1 represents a lower alkyl group which may be substituted with a halogen atom, or a halogen atom; R2 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a halogen atom, a hydroxyl group, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted acylamino group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, or a substituted or unsubstituted lower alkylureido group; and X, Y and Z each independently represents a hydrogen atom, a substituted or unsubstituted lower alkyl group, a halogen atom, a hydroxyl group, a carboxyl group, a lower alkoxycarbonyl group, a cyano group, a carbamoyl group, a substituted or unsubstituted lower alkoxy group, a substituted or unsubstituted amino group, a substituted or unsubstituted lower alkoxycarbonylamino group, a substituted or unsubstituted lower alkylaminocarbonyl group, a lower alkylsulfonylamino group, a substituted or unsubstituted lower alkylureido group, or a substituted or unsubstituted acylamino group, or X and Y may be combined to form a 5- to 6-membered ring forming a bicyclic fused ring, wherein the 5- to 6-membered ring may optionally have a substituent, provided that when X and Y are not combined to form a fused ring, R2 represents a hydrogen atom and, when X and Y are combined to form a fused ring, a saturated or unsaturated, bicyclic alicyclic or heterocyclic fused ring can be formed.