N-Protected N-Carboxyanhydrides IX. Synthesis of N-Aralkyl α-Amino Acid N-Carboxyanhydrides by Carbonyl Insertion with Bis(N-Succinimidyl)Carbonate
Cyclization of N-aralkyl α-amino acids to N-carboxyanhydrides without using phosgene is reported.The weakly acidic reaction conditions allow a safe preparation od new acid-labile derivatives in peptide synthesis.
Halstroem, John,Kovacs, Karoly
p. 462 - 465
(2007/10/02)
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