1082949-99-2Relevant articles and documents
NOVEL IMIDAZOLE AMINES AS MODULATORS OF KINASE ACTIVITY
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, (2013/03/28)
The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
Rapid development and scale-up of a 1 H -4-substituted imidazole intermediate enabled by chemistry in continuous plug flow reactors
May, Scott A.,Johnson, Martin D.,Braden, Timothy M.,Calvin, Joel R.,Haeberle, Brian D.,Jines, Amy R.,Miller, Richard D.,Plocharczyk, Edward F.,Rener, Gregory A.,Richey, Rachel N.,Schmid, Christopher R.,Vaid, Radhe K.,Yu, Hannah
, p. 982 - 1002 (2012/08/27)
The development of reactions in a continuous fashion in plug flow tube reactors (PFR) offers unique advantages to the drug development and scale-up process and can also enable chemistry that would be difficult to perform via batch processing. Herein, we r
AKT AND P70 S6 KINASE INHIBITORS
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Page/Page column 62, (2010/06/11)
The present invention provides AKT and p70 S6 kinase inhibitors of the formula: The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and methods of using compounds of Formula I.
P70 S6 KINASE INHIBITORS
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Page/Page column 64, (2009/01/20)
The present invention provides p70 S6 kinase inhibitors of the formula: pharmaceutical formulations comprising them, and methods for their use.