84358-13-4

Usage

Uses

Used in Pharmaceutical Industry:
N-BOC-piperidine-4-carboxylic acid is used as a pharmaceutical intermediate for the development of various drug molecules. It plays a crucial role in the synthesis of camptothecin ester of isonipecotic acid, which is then installed on a triazine dendrimer intermediate. This process is carried out through an iterative, scalable route, ultimately yielding cationic and PEGylated targets with activities in cell culture comparable to free drug. This application allows for the enhancement of drug properties, leading to improved therapeutic outcomes.

InChI:InChI=1/C11H19NO4/c1-11(2,3)16-10(15)12-6-4-8(5-7-12)9(13)14/h8H,4-7H2,1-3H3,(H,13,14)/p-1

Upstream product

• 1146955-04-5 4-bromo-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester 
• 307496-27-1 2-bromobenzylzinc(II) bromide 

Downstream Products

• 1017781-50-8 4-[3-(4-Chloro-phenyl)-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 176915-47-2 4-[3-(4-Chloro-phenyl)-2-methyl-3-oxo-propionyl]-piperidine-1-carboxylic acid tert-butyl ester 
• 123855-51-6 tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate 
• 280115-99-3 tert-butyl 4-(chlorocarbonyl)-piperidine-1-carboxylate 
• 327048-63-5 N-(tert-butoxycarbonyl)-4-(4-fluorophenylmethylamidoacetyl)piperidine 
• 293744-26-0 tert-butyl 4-{[(2-bromophenyl)amino]carbonyl}piperidine-1-carboxylate 
• 479630-08-5 4-(2-ethoxycarbonylacetyl)piperidine-1-carboxylic acid tert-butyl ester 
• 514221-85-3 piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-[4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decylsulfanyl)-phenyl] ester 
• 2971-79-1 isonipecotic acid methyl ester 
• 124443-68-1 1-tert-Butyl 4-methyl piperidine-1,4-dicarboxylate 
• 736150-27-9 4-[3-(4-phenoxyphenyl)-3-oxopropanoyl]piperidine-1-carboxylic acid tert-butyl ester 
• 512818-39-2 4-(3,5-bis-trifluoromethyl-benzenesulfonylaminocarbonyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 419571-68-9 4-(3-oxo-butyrl)-piperidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Formation of quaternary carbons through cobalt-catalyzed C(sp3)-C(sp3) Negishi cross-coupling

Formation of all-carbon-substituted quaternary carbons is a key challenge in organic and medicinal chemistry. We report a cobalt-catalyzed C(sp3)-C(sp3) cross-coupling that allows for the introduction of benzyl, heteroarylmethylzinc and allyl groups to halo-carbonyl substrates. The cross-coupling reaction is selective for C(sp3)-over C(sp2)-halides, in contrast to most used catalytic metals, and allows access to novel scaffolds of pharmaceutical interest. NMR mechanistic studies suggest the presence of Co(0) complexes as catalytic species. This journal is

1,4-Disubstituted-piperidinyl compounds useful as analgesics and muscle relaxants

The present invention relates to 1,4-disubstituted-piperidinyl compounds and their use as analgesic agents and as muscle relaxants.