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108319-06-8

Temafloxacin is a fluoroquinolone antibiotic that acts as a DNA topoisomerase inhibitor. It has broad antimicrobial activity against gram-positive and gram-negative bacteria, such as S. pneumoniae, M. hominis, and anaerobic bacteria, including B. fragilis.

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  • 3-Quinolinecarboxylicacid,1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-

    Cas No: 108319-06-8

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  • 108319-06-8 Structure

  • Basic information

    1. Product Name: TEMAFLOXACIN
    2. Synonyms: Teflox;6-Fluoro-1-(2,4-difluorophenyl)-7-(3-methylpiperazin-1-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid;TeMafloxacin HCl;TEMAFLOXACIN;AKOS 92085;1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl) -4-oxo-3-quinoline-carboxylic acid;1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-quino line-3-carboxylic acid hydrochloride;A-62254
    3. CAS NO:108319-06-8
    4. Molecular Formula: C21H18F3N3O3
    5. Molecular Weight: 417.38
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 108319-06-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 608.9°Cat760mmHg
    3. Flash Point: 322.1°C
    4. Appearance: /
    5. Density: 1.3372 (estimate)
    6. Vapor Pressure: 1.11E-15mmHg at 25°C
    7. Refractive Index: 1.603
    8. Storage Temp.: 2-8°C(protect from light)
    9. Solubility: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
    10. Stability: Hygroscopic
    11. CAS DataBase Reference: TEMAFLOXACIN(CAS DataBase Reference)
    12. NIST Chemistry Reference: TEMAFLOXACIN(108319-06-8)
    13. EPA Substance Registry System: TEMAFLOXACIN(108319-06-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 108319-06-8(Hazardous Substances Data)

108319-06-8 Usage

Uses

Used in Pharmaceutical Industry:
Temafloxacin is used as an antimicrobial quinolone drug for treating bacterial infections caused by susceptible strains of the designated microorganisms. Its broad-spectrum activity makes it effective against a wide range of bacteria, including both gram-positive and gram-negative types.
Brand names:
Omniflox (Abbott), Teflox, Temac.

World Health Organization (WHO)

Temafloxacin, a quinolone antimicrobial, was introduced in 1991. Shortly afterwards, its use became associated with severe adverse effects, including hypoglycaemia, haemolytic anaemia, renal failure, hepatitis and anaphylactic reactions. This led to its worldwide withdrawal by the manufacturer.

Check Digit Verification of cas no

The CAS Registry Mumber 108319-06-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,3,1 and 9 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 108319-06:
(8*1)+(7*0)+(6*8)+(5*3)+(4*1)+(3*9)+(2*0)+(1*6)=108
108 % 10 = 8
So 108319-06-8 is a valid CAS Registry Number.
InChI:InChI=1/C21H18F3N3O3/c1-11-9-26(5-4-25-11)19-8-18-13(7-16(19)24)20(28)14(21(29)30)10-27(18)17-3-2-12(22)6-15(17)23/h2-3,6-8,10-11,25H,4-5,9H2,1H3,(H,29,30)

108319-06-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(2,4-difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid

1.2 Other means of identification

Product number -
Other names [14C]-Temafloxacin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:108319-06-8 SDS

108319-06-8Upstream product

108319-06-8Downstream Products

108319-06-8Related news

In vitro susceptibility to TEMAFLOXACIN (cas 108319-06-8) in female genital tract Bacteroides isolates08/26/2019

Agar dilution susceptibility testing of temafloxacin, cefotetan, clindamycin, and ciprofloxacin was performed in 103 genital tract isolates of Bacteroides. The respective minimum inhibitory concentration inhibiting 90% of the strains tested were temafloxacin, 4 μg/ml; cefotetan, 256 μg/ml; cli...detailed

Comparative pharmacokinetics of ciprofloxacin and TEMAFLOXACIN (cas 108319-06-8) in humans: A review08/25/2019

Temafloxacin is a new antibacterial agent of the fluoroquinolone group. In comparison with ciprofloxacin, the current leading quinolone, temafloxacin shows higher and longer lasting plasma concentrations after equivalent doses due to an almost complete gastrointestinal absorption and a lower tot...detailed

108319-06-8Relevant articles and documents

NOVEL METHOD OF SYNTHESIS OF FLUOROQUINOLONES

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Page/Page column 6; 9, (2009/04/24)

The invention relates to a method of preparation of fluoroquinolones of formula (I) from compounds of formula (II): in which R1, R2, R3, R4, R5, R6, R7, and X are as defined in Claim 1.

Quinoline antibacterial compounds

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, (2008/06/13)

Quinoline compounds having the formula: STR1 wherein R is a phenyl group or an aromatic heterocyclic group, Z is an aliphatic heterocyclic group or an amine, and R1 is hydrogen or a carboxy-protecting group. The compounds here disclosed have an

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