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| CAS No.: | 108319-06-8 |
|---|---|
| Name: | TEMAFLOXACIN |
| Molecular Structure: | |
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| Formula: | C21H18 F3 N3 O3 |
| Molecular Weight: | 417.387 |
| Synonyms: | (?à)-Temafloxacin;1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylicacid; A 62254; A 63004; T 1258; Teflox; Temac; Temafloxacin |
| Density: | 1.427g/cm3 |
| Boiling Point: | 608.9°Cat760mmHg |
| Flash Point: | 322.1°C |
| Safety: | Mutation data reported. When heated to decomposition it emits toxic vapors of F− and Cl−. |
| PSA: | 74.57000 |
| LogP: | 3.29810 |
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Chemistry
IUPAC Name: 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid
Synonyms: 1-(2,4-Difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic Acid ; 1-(2,4-Difluorophenyl)-6-fluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ; 3-Quinolinecarboxylic acid, 1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-
CAS NO: 108319-06-8
Molecular Formula of Temafloxacin (CAS NO.108319-06-8): C21H18F3N3O3
Molecular Weight of Temafloxacin (CAS NO.108319-06-8) : 417.38
Molecular Structure of Temafloxacin (CAS NO.108319-06-8) : .png)
Index of Refraction: 1.603
Surface Tension: 52.6 dyne/cm
Density: 1.427 g/cm3
Flash Point: 322.1 °C
Enthalpy of Vaporization: 95.11 kJ/mol
Boiling Point: 608.9 °C at 760 mmHg
Vapour Pressure: 1.11E-15 mmHg at 25°C
Appearance: ethanol in the crystal,
Melting point :274-276°C
Uses
Temafloxacin (CAS NO.108319-06-8) is used as antibacterial drugs for lower respiratory tract infections and urinary tract infections, sexually transmitted diseases, skin and soft tissue infections.
Production
Raw materials :Sodium hydride -->1,2-Dimethoxyethane-->Diethyl carbonate-->2,4-Difluoroaniline-->2,4-Dichloro-5-fluoroacetophenone-->2-Methylpiperazine
Condensation of 2,4 - Dichloro--5 - Fluoroacetophenone and Diethyl carbonate , then condensation with Triethyl orthoformate , and then, condensation with 2,4 - Difluoro-aniline . Then, reflux and cyclization in Ethylene glycol dimethyl ether in the presence of Sodium hydride . After hydrolysis, condensation with 2 - Methyl-piperazine ,obtaining Temafloxacin (CAS NO.108319-06-8).
Toxicity Data With Reference
| 1. | mic-bac-sat 60 µg/L AACHAX 37,213,93 | |
| 2. | uns-bac-esc 50 µg/L AACHAX 37,213,93 | |
| 3. | pic-bac-esc 50 µg/L AACHAX 37,213,93 | |
| 4. | dnr-bcs 20 mg/L AACHAX 37,213,93 |
Safety Profile
Mutation data reported. When heated to decomposition it emits toxic vapors of F− and Cl−.