- 5-Aryl-4-carboxamide-1,3-oxazoles: Potent and selective GSK-3 inhibitors
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5-Aryl-4-carboxamide-1,3-oxazoles are a novel, potent and selective series of GSK-3 inhibitors. The optimization of the series to yield compounds with cell activity and brain permeability is described.
- Gentile, Gabriella,Merlo, Giancarlo,Pozzan, Alfonso,Bernasconi, Giovanni,Bax, Benjamin,Bamborough, Paul,Bridges, Angela,Carter, Paul,Neu, Margarete,Yao, Gang,Brough, Caroline,Cutler, Geoffrey,Coffin, Aaron,Belyanskaya, Svetlana
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scheme or table
p. 1989 - 1994
(2012/04/17)
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- FLUORINATED AMINOTRIAZOLE DERIVATIVES
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The invention relates to fluorinated aminotriazole derivatives of formula (I), wherein A, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds.
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Page/Page column 62
(2010/12/29)
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- AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS
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The invention relates to aminotriazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds. The compounds are useful for the prevention or treatment of diseases, which respond to the modulation of the ALX receptor such as inflammatory diseases.
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Page/Page column 114
(2009/07/18)
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