- Microwave synthesis method of 6-trifluoromethylpyridylaldehyde
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The invention relates to a microwave synthesis method of 6-trifluoromethylpyridylaldehyde. According to the method, a reaction is performed in a reaction tank by using a microwave irradiation technique; 1 eq of 6-trifluoromethylpyridinemethanol is added, a solvent is added to dissolve 6-trifluoromethylpyridinemethanol, 0.01-0.1 eq of a catalyst and 1-1.5 eq of an oxidant are added, microwave powerand temperature are set to react after feeding is finished, after the reaction is finished, rotary evaporation and concentration is performed on the reaction solution to obtain a solid product, and finally the solid product is separated and purified to obtain the 6-trifluoromethylpyridylaldehyde. Compared with the prior art, the method provided by the invention has the advantages of short reaction time, mild conditions, few side reactions and high yield, simplifies the production process, reduces the production cost and cycle, is easy to realize the popularization of industrial production, and is especially suitable for large-scale production of an intermediate 6-trifluoromethyl nicotinaldehyde of a colony stimulating factor 1 receptor (CSF-1R) inhibitor.
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Paragraph 0039; 0040
(2021/01/20)
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- KCNT1 INHIBITORS AND METHODS OF USE
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The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.
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Page/Page column 52-53
(2021/10/02)
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- PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS
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The present invention is directed to compounds of Formula I pharmaceutical compositions comprising the same, and their use in the inhibition of HIV protease, the inhibition of HIV replication, the prophylaxis of infection by HIV, the treatment of infection by HIV, and the prophylaxis, treatment, and delay in the onset or progression of AIDS.
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Page/Page column 69; 70
(2015/10/05)
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