108349-67-3Relevant articles and documents
Ir-Catalyzed Intramolecular Transannulation/C(sp2)-H Amination of 1,2,3,4-Tetrazoles by Electrocyclization
Das, Sandip Kumar,Roy, Satyajit,Khatua, Hillol,Chattopadhyay, Buddhadeb
supporting information, p. 8429 - 8433 (2018/07/09)
An efficient strategy for the intramolecular denitrogenative transannulation/C(sp2)-H amination of 1,2,3,4-tetrazoles bearing C8-substituted arenes, heteroarenes, and alkenes is described. The process involves the generation of the metal-nitrene intermediate from tetrazole by the combination of [CpIrCl2]2 and AgSbF6. It has been shown that the reaction proceeds via an unprecedented electrocyclization process. The method has been successfully applied for the synthesis of a diverse array of α-carbolines and 7-azaindoles.
CaMKII INHIBITORS AND USES THEREOF
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Paragraph 00358-00362; 00368-00369, (2016/05/02)
The present invention provides compounds useful as inhibitors of Ca2+/calmodulin-dependent protein kinase (CaMKII), compositions thereof, and methods of using the same.
CaMKII INHIBITORS AND USES THEREOF
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Paragraph 00247-00248; 00258-00259, (2014/09/29)
The present invention provides compounds useful as inhibitors of Ca2+/calmodulindependent protein kinase (CaMKII), compositions thereof, and methods of using the same. Cardiovascular disease remains the number one cause of death in developed countries. Furthermore, incidence of cardiovascular disease has increased dramatically in developing countries. Although cardiovascular disease usually affects older adults, the antecedents of cardiovascular disease, notably atherosclerosis, begin in early life, making primary prevention efforts necessary from childhood.
A short entry into the pyrido[2,3-b] indole ring system. Synthesis of the tetracyclic segment of the marine antitumor agents: Grossularines-1 and -2
Achab, Said,Guyot, Michele,Potier, Pierre
, p. 2127 - 2130 (2007/10/02)
A new method for the synthesis of substituted pyrido[2,3-b] indoles (α-carbolines) (14, 27-31), featuring Pd-catalyzed cross coupling between pyridine and aniline derivatives and subsequent intramolecular cylization, has been developed. This method provid