86119-84-8Relevant articles and documents
Regulating Higher-Order Organization through the Synergy of Two Self-Sorted Assemblies
Ji, Wei,Zhang, Shijin,Yukawa, Sachie,Onomura, Shogo,Sasaki, Toshio,Miyazawa, Kun'ichi,Zhang, Ye
, p. 3636 - 3640 (2018)
The extracellular matrix (ECM) is the natural fibrous scaffold that regulates cell behavior in a hierarchical manner. By mimicking the dynamic and reciprocal interactions between ECM and cells, higher-order molecular self-assembly (SA), mediated through the dynamic growth of scaffold-like nanostructures assembled by different molecular components, was developed. Designed and synthesized were two self-sorted coumarin-based gelators, a peptide molecule and a benzoate molecule, which self-assemble into nanofibers and nanobelts, respectively, with different dynamic profiles. Upon the dynamic growth of the fibrous scaffold assembled from peptide gelators, nanobelts assembled from benzoate gelators transform into a layer-by-layer nanosheet, reaching ninefold increase in height. By using light and an enzyme, the spatial–temporal growth of the scaffold can be modified, leading to in situ height regulation of the higher-order architecture.
Synthesis, Stability, and Kinetics of Hydrogen Sulfide Release of Dithiophosphates
Bowden, Ned B.,Brown, Eric M.,Paudel, Arjun,Ranasinghe Arachchige, Nimesh P. R.
, p. 12900 - 12908 (2021/11/17)
The development of chemicals to slowly release hydrogen sulfide would aid the survival of plants under environmental stressors as well as increase harvest yields. We report a series of dialkyldithiophosphates and disulfidedithiophosphates that slowly degrade to release hydrogen sulfide in the presence of water. Kinetics of the degradation of these chemicals were obtained at 85 °C and room temperature, and it was shown that the identity of the alkyl or sulfide group had a large impact on the rate of hydrolysis, and the rate constant varied by more than 104×. For example, using tert-butanol as the nucleophile yielded a dithiophosphate (8) that hydrolyzed 13,750× faster than the dithiophosphate synthesized from n-butanol (1), indicating that the rate of hydrolysis is structure-dependent. The rates of hydrolysis at 85 °C varied from a low value of 6.9 × 10-4 h-1 to a high value of 14.1 h-1. Hydrogen sulfide release in water was also quantified using a hydrogen sulfide-sensitive electrode. Corn was grown on an industrial scale and dosed with dibutyldithiophosphate to show that these dithiophosphates have potential applications in agriculture. At a loading of 2 kg per acre, a 6.4% increase in the harvest yield of corn was observed.
Hydrolysis of element (White) phosphorus under the action of heterometallic cubane-type cluster {mo3pds4}
Babaev, Vasily M.,Gushchin, Artem L.,Khayarov, Khasan R.,Kuchkaev, Aidar M.,Kuchkaev, Airat M.,Shmelev, Nikita Y.,Sinyashin, Oleg G.,Sokolov, Maxim N.,Sukhov, Aleksandr V.,Yakhvarov, Dmitry G.
, (2021/05/28)
Reaction of heterometallic cubane-type cluster complexes—[Mo3{Pd(dba)}S4Cl3(dbbpy)3]PF6, [Mo3{Pd(tu)}S4Cl3(dbbpy)3]Cl and [Mo3{Pd(dba)}S4/s
Tunable pH-sensitive 2-carboxybenzyl phosphoramidate cleavable linkers
Backer, Brian S.,Berkman, Clifford E.,Browne, Zachery S.,Choy, Cindy J.,Davis, Austen L.
supporting information, (2020/02/15)
We previously described a pH-sensitive phosphoramidate linker scaffold that can be tuned to release amine-containing drugs at various pH values. In these previous studies it was determined that the tunability of this linker was dependent upon the proximity of an acidic group (e.g., carboxylic acid or pyridinium). In this study, we confirmed that the tunability of pH-triggered amine-release was also dependent upon the pKa of the proximal acidic group. A series of 2-carboxybenzyl phosphoramidates was prepared in which the pKa of the proximal benzoic acid was predictably attenuated by substituents on the benzoate ring consistent with their σ-values.
