108446-79-3

Basic information

• Product Name: 3-(4-CHLOROPHENYL)-1-PHENYLPYRAZOLE-4-P&
• Synonyms: 3-[3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl]propanoic acid
• CAS NO: 108446-79-3
• Molecular Formula: C₁₈H₁₅ClN₂O₂
• Molecular Weight: 326.781
• Product Categories: PyrazolesHeterocyclic Building Blocks;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrazoles
• Mol File: 108446-79-3.mol

Chemical Properties

• Melting Point: 153-157 °C
• Boiling Point: 532.1°C at 760 mmHg
• Flash Point: 275.6°C
• Appearance: /
• Density: 1.27g/cm³
• Vapor Pressure: 3.74E-12mmHg at 25°C
• Refractive Index: 1.63
• CAS DataBase Reference: 3-(4-CHLOROPHENYL)-1-PHENYLPYRAZOLE-4-P&(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLOROPHENYL)-1-PHENYLPYRAZOLE-4-P&(108446-79-3)
• EPA Substance Registry System: 3-(4-CHLOROPHENYL)-1-PHENYLPYRAZOLE-4-P&(108446-79-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 108446-79-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H15ClN2O2/c19-15-9-6-13(7-10-15)18-14(8-11-17(22)23)12-21(20-18)16-4-2-1-3-5-16/h1-7,9-10,12H,8,11H2,(H,22,23)

Upstream product

• 57845-08-6 p-chloroacetophenone phenylhydrazone 
• 108446-85-1 2-[3-(4-Chloro-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid diethyl ester 
• 108446-67-9 2-[3-(4-Chloro-phenyl)-1-phenyl-1H-pyrazol-4-ylmethylene]-malonic acid 
• 36663-00-0 1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde 
• 2033-24-1 cycl-isopropylidene malonate 
• 55432-14-9 3-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)acrylic acid 

Downstream Products

• 519137-54-3 3-[3-(4-chloro-phenyl)-1-phenyl-1H-pyrazol-4-yl]-propionyl chloride 

Relevant articles and documents

1,3-Diarylpyrazolyl-acylsulfonamides as Potent Anti-tuberculosis Agents Targeting Cell Wall Biosynthesis in Mycobacterium tuberculosis

Phenotypic whole cell high-throughput screening of a μ150,000 diverse set of compounds against Mycobacterium tuberculosis (Mtb) in cholesterol-containing media identified 1,3-diarylpyrazolyl-acylsulfonamide 1 as a moderately active hit. Structure-activity

A simple and rapid synthesis of 4H-4-oxo-1-benzopyran-3-yl and 1,3-diarylpyrazol-4-yl propanoic acids

A simple and rapid synthesis of 4H-4-oxo-1-benzopyran-3-yl (4a-h) and 1,3-diarylpyrazol-4-yl propanoic acids (5a-h) using Meldrum's acid (1) from the corresponding carboxaldehydes (2 & 3) is reported herein.

Functionally substituted 3-heterylpyrazoles: XI. 3-[3-Aryl(heteryl)pyrazol-4-yl]propenoic and propanoic acids

3-Aryl(heteryl)-4-formylpyrazoles by condensation with malonic acid furnish 3-[3-aryl(heteryl)-pyrazol-4-yl]propenoic acids that in the presence of Raney nickel are reduced by hydrazine hydrate to 3-[3-aryl(heteryl)pyrazol-4-yl]propanoic acids. The succes

Azoles. 17. Beta-(4-pyrazol)acrylic and propionic acids and their anti-inflammatory activity

beta-(4-Pyrazole)acrylic acids 22-28 were prepared by the Knoevenagel reaction of malonic acid and 4-formylpyrazoles 8-14. 4-Pyrazolemethylenemalonic acids 15-21 were isolated as intermediates. The latter compounds were also synthesized by treating the 4-formylpyrazoles 8-14 with diethyl malonate followed by hydrolysis of the obtained diethyl esters 15a-21a. The effect of piperidine and pyridine on the Knoevenagel condensation was investigated. The beta-(4-pyrazole)acrylic acids 22-27, on catalytic reduction, gave the corresponding beta-(4-pyrazole)propionic acids 29-34. Compounds 23, 24, 27, 29-31 and 34 appeared to be less active than phenylbutazone in carrageenin-induced oedema test, but they were less toxic than the reference drug.

1,3-Diaryl-pyrazol-4-acrylic acid and derivatives

The invention concerns diarylpyrazole lower alkanoic acids and derivatives which are pharmacologically efficacious as anti-inflammatory agents. The said compounds can be represented by the formula STR1 in which one of D, E, F and G represents hydrogen, one is a lower aliphatic acid radical or derivative thereof and the remaining two of D, E, F and G are aryl or heteroaryl radicals.