METHYLPHOSPHINYL (Dmp): A NEW PROTECTING GROUP OF TYROSINE SUITABLE FOR PEPTIDE SYNTHESIS BY USE OF BOC-AMINO ACIDS
Use of dimethylphosphinyl (Dmp) group as a side-chain phenolic OH protecting group of tyrosine in peptide synthesis was studied.The Dmp group is resistant to trifluoroacetic acid and hydrogenolysis and removed by fluoride ion or liquid HF.