108615-85-6Relevant articles and documents
Palladium-Catalyzed Fluoroarylation of gem-Difluoroalkenes
Tang, Hai-Jun,Lin, Ling-Zhi,Feng, Chao,Loh, Teck-Peng
supporting information, p. 9872 - 9876 (2017/08/08)
A Pd-catalyzed fluoroarylation of gem-difluoroalkenes with aryl halides is reported. By taking advantage of the in situ generated α-CF3-benzylsilver intermediates derived from the nucleophilic addition of silver fluoride to gem-difluoroalkenes, this strategy bypasses the use of a strong base, thus enabling a mild and general synthetic method for ready access to non-symmetric α,α-disubstituted trifluoroethane derivatives.
F- Nucleophilic-Addition-Induced Allylic Alkylation
Tian, Panpan,Wang, Cheng-Qiang,Cai, Sai-Hu,Song, Shengjin,Ye, Lu,Feng, Chao,Loh, Teck-Peng
supporting information, p. 15869 - 15872 (2016/12/23)
Herein we present a novel strategy based on palladium-catalyzed allylic alkylation by taking advantage of the nucleophilic addition of external fluoride onto gem-difluoroalkenes as the initiation step. The merit of this protocol is highly appealing, as it enables a formal allylation of trifluoroethylarene derivatives through the in situ generation of β-trifluorocarbanions, which otherwise are deemed to be problematic in deprotonative allylation. Furthermore, this strategy distinguishes itself by high modularity, operational simplicity, and wide substrate scope with respect to allyl carbonates, giving rise to a broad array of homoallyltrifluoromethane derivatives, which otherwise would not be easily obtained using existing synthetic methods.
Fluorovinylzinc Reagents: Access to Fluorovinyl Ketones, Esters, and Heterocycles
Gillet, J. P.,Sauvetre, R.,Normant, J. F.
, p. 538 - 543 (2007/10/02)
Several fluorovinylzinc reagents have been prepared.Palladium-catalyzed cross coupling reactions give stereoselectively fluorinated compounds.
