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1121-60-4

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1121-60-4 Usage

Description

2-Pyridinecarboxaldehyde is a pyridinecarbaldehyde that is pyridine in which the hydrogen at position 2 is replaced by a formyl group. It is a yellow liquid and is known for its versatile chemical properties.

Uses

Used in Chitosan-based Bifunctionalized Adsorbent Synthesis:
2-Pyridinecarboxaldehyde is used as a key component in the synthesis of chitosan-based bifunctionalized adsorbents. It contributes to the development of adsorbents with enhanced properties for various applications.
Used in Aldol Addition Reactions:
In the field of biocatalysis, 2-Pyridinecarboxaldehyde is used as a reactant in aldol addition reactions with pyruvate in the presence of 2-keto-3-deoxy-6-phosphogluconate aldolase (KDPG) catalyst. This reaction forms (S)-4-hydroxy-2-keto-4-(2′-pyridyl)butyrate, which is an important intermediate in various biochemical processes.
Used in Chiral Schiff Base Compounds Synthesis:
2-Pyridinecarboxaldehyde is used as a reactant in the condensation reaction with (S)-(?)-α-methylbenzylamine and (R)-(+)-α-methylbenzylamine to synthesize two chiral (S)-(?)and (R)-(+)Schiff base compounds. These compounds have potential applications in various fields, such as pharmaceuticals and materials science.
Used in Metal Complex Formation:
2-Pyridinecarboxaldehyde can be combined with thiosemicarbazide to form 2-pyridinecarboxaldehyde thiosemicarbazone ligand (L). This ligand can further complex with Ni(II) and Cu(II) salts (MX) to form [M(L)2X2] complexes. These complexes have potential applications in catalysis, materials science, and other fields.

Synthesis Reference(s)

Synthetic Communications, 23, p. 1775, 1993 DOI: 10.1080/00397919308011276

Purification Methods

Purification is achieved by bubbling sulfur dioxide into a solution of 50g of the aldehyde in 250mL of boiled water, under nitrogen, at 0o, until precipitation is complete. The bisulfite addition compound is filtered off rapidly and, after washing with a little water, is refluxed in 17% HCl (200mL) under nitrogen until a clear solution is obtained. Neutralisation with NaHCO3 and extraction with ether separated the aldehyde which is recovered by drying the extract, then distilling twice, under nitrogen. [Kyte et al. J Chem Soc 4454 1960, Beilstein 21 I 287, 21 III/IV 3495, 21/7 V 293.]

Check Digit Verification of cas no

The CAS Registry Mumber 1121-60-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,2 and 1 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1121-60:
(6*1)+(5*1)+(4*2)+(3*1)+(2*6)+(1*0)=34
34 % 10 = 4
So 1121-60-4 is a valid CAS Registry Number.
InChI:InChI=1/C6H5NO/c8-5-6-3-1-2-4-7-6/h1-5H

1121-60-4 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
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  • Detail
  • TCI America

  • (P0425)  2-Pyridinecarboxaldehyde  >98.0%(GC)

  • 1121-60-4

  • 25g

  • 380.00CNY

  • Detail
  • TCI America

  • (P0425)  2-Pyridinecarboxaldehyde  >98.0%(GC)

  • 1121-60-4

  • 100g

  • 990.00CNY

  • Detail
  • TCI America

  • (P0425)  2-Pyridinecarboxaldehyde  >98.0%(GC)

  • 1121-60-4

  • 500g

  • 2,870.00CNY

  • Detail
  • Alfa Aesar

  • (A11391)  Pyridine-2-carboxaldehyde, 99%   

  • 1121-60-4

  • 25g

  • 209.0CNY

  • Detail
  • Alfa Aesar

  • (A11391)  Pyridine-2-carboxaldehyde, 99%   

  • 1121-60-4

  • 100g

  • 511.0CNY

  • Detail
  • Alfa Aesar

  • (A11391)  Pyridine-2-carboxaldehyde, 99%   

  • 1121-60-4

  • 500g

  • 1946.0CNY

  • Detail
  • Aldrich

  • (P62003)  2-Pyridinecarboxaldehyde  99%

  • 1121-60-4

  • P62003-25G

  • 209.43CNY

  • Detail
  • Aldrich

  • (P62003)  2-Pyridinecarboxaldehyde  99%

  • 1121-60-4

  • P62003-100G

  • 510.12CNY

  • Detail
  • Aldrich

  • (P62003)  2-Pyridinecarboxaldehyde  99%

  • 1121-60-4

  • P62003-500G

  • 2,577.51CNY

  • Detail

1121-60-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-formylpyridine

1.2 Other means of identification

Product number -
Other names 2-Pyridinecarboxaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1121-60-4 SDS

1121-60-4Synthetic route

2-Hydroxymethylpyridine
586-98-1

2-Hydroxymethylpyridine

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With sodium hypochlorite; β‐cyclodextrin In water at 50℃; for 1h;99%
With tert.-butylhydroperoxide; V/SiO2 In decane; tert-butyl alcohol at 25℃; for 5h;99.1%
With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen In acetonitrile at 75℃; under 760.051 Torr; for 12h;99%
2-Cyanopyridine
100-70-9

2-Cyanopyridine

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With potassium carbonate In water; dimethyl sulfoxide at 60℃; for 8h; High pressure; Green chemistry;99.9%
With C13H26B(1-)*K(1+) In tetrahydrofuran for 24h; Ambient temperature;73%
Stage #1: 2-Cyanopyridine With diisobutylaluminium hydride In toluene at 20℃; for 0.222222h; Flow reactor;
Stage #2: With water; sodium L-tartrate In toluene at 0℃; chemoselective reaction;
56%
2-vinylpyridine
100-69-6

2-vinylpyridine

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With dihydrogen peroxide In water at 100℃; for 4h;95%
With sodium periodate; C53H44As2N2O3Ru In water; ethyl acetate; acetonitrile at 25℃; for 0.5h;82%
Stage #1: 2-vinylpyridine With oxygen; ozone In dichloromethane at -78℃;
Stage #2: With poly(ethylene glycol)-triphenylphosphine In dichloromethane at -78 - 20℃;
63%
ethyl-2-picolinate
2524-52-9

ethyl-2-picolinate

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With n-butyllithium; diisobutylaluminium hydride; tert-butyl alcohol In tetrahydrofuran; hexane at 0℃;94%
Multi-step reaction with 2 steps
1: diethyl ether; lithium alanate
2: lead (IV)-acetate; benzene
View Scheme
With diisobutylaluminium hydride In dichloromethane; water; isopropyl alcohol; toluene
triazolopyridine
274-59-9

triazolopyridine

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With selenium(IV) oxide In chlorobenzene at 132℃; for 6h;92%
2-[1,3]Dithiolan-2-yl-pyridine

2-[1,3]Dithiolan-2-yl-pyridine

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With thionyl chloride; dihydrogen peroxide In acetonitrile at 25℃; for 0.0166667h;92%
2-Picolinic acid
98-98-6

2-Picolinic acid

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With (CH3)2NCH2NpSiH2Ph at 110 - 140℃;90%
With D-glucose; sodium citrate; magnesium chloride In aq. phosphate buffer at 28℃; for 3h; pH=7.4; Enzymatic reaction;
With carboxylic acid reductase Kinetics; Green chemistry; Enzymatic reaction;
α-picoline
109-06-8

α-picoline

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With nickel-doped graphene carbon nitride nanoparticles; air In ethanol at 25℃; for 8h; Irradiation; Green chemistry;89%
With sodium persulfate; Ni(N,N′‑dimethyl‑N,N′‑bis(pyridine‑2‑ylmethyl)‑1,2‑diaminoethane)Cl2 In acetonitrile at 20℃; for 6h;81%
With water; oxygen; CrV0.95P0.05O4 at 299.84℃;50.2%
2-pyridinealdoxime
873-69-8

2-pyridinealdoxime

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With zinc(II) nitrate; silica gel for 0.0666667h; deoxymation; Irradiation;89%
With cellulose supported Cu-nanoparticles In water at 80℃; for 0.0833333h; Microwave irradiation; Green chemistry;79%
With iodine; sodium dodecyl-sulfate In water at 25 - 40℃; for 4h;71%
With aluminum(III) nitrate nonahydrate; sodium bromide In dichloromethane at 20℃; for 30.5h;58%
N-methyl-2-pyridinemethanamine
21035-59-6

N-methyl-2-pyridinemethanamine

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In chloroform for 24h; Reflux;89%
With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione In chloroform for 24h; Reflux;85%
3,6,6-Trimethyl-4-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-4,6-dihydro-1H-cyclopenta[1,2,4]triazine-5,7-dicarboxylic acid dimethyl ester
117227-38-0

3,6,6-Trimethyl-4-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-4,6-dihydro-1H-cyclopenta[1,2,4]triazine-5,7-dicarboxylic acid dimethyl ester

A

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

B

2-Cyanopyridine
100-70-9

2-Cyanopyridine

Conditions
ConditionsYield
With sodium methylate In ethanol for 3h; Product distribution; Heating;A 8%
B 88%
2-pyridinylidenehydrazinodiacetic acid

2-pyridinylidenehydrazinodiacetic acid

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With copper(II) nitrate hexahydrate In dichloromethane; water at 20℃; for 3h;88%
2-pyridinecarboxaldehyde N-oxide
7216-40-2

2-pyridinecarboxaldehyde N-oxide

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With ammonium formate; silica gel; zinc In methanol at 20℃; for 0.166667h; chemoselective reaction;88%
2-(1,3-dioxolan-2-yl)pyridine
5693-54-9

2-(1,3-dioxolan-2-yl)pyridine

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With ammonium nitrate; Montmorillonite-K10 for 0.05h; deprotection; microwave irradiation;86%
With lithium chloride In water; dimethyl sulfoxide at 130℃; for 18h;76%
(CH3CNO)2(CH3CNOH)2Co(C5H5N)(OOCH2C5H4N)

(CH3CNO)2(CH3CNOH)2Co(C5H5N)(OOCH2C5H4N)

A

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

B

2-Hydroxymethylpyridine
586-98-1

2-Hydroxymethylpyridine

Conditions
ConditionsYield
In methanol decomposition of the complex by refluxing in methanol under N2 for 6-8 h; evapn. of the solvent, extn. of the organic compounds with ether, gas chromatography;A 14%
B 86%
2-pyridineacetic acid
13115-43-0

2-pyridineacetic acid

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With potassium carbonate In chloroform at 20℃; for 24h; Irradiation; Inert atmosphere;85%
2-nitrooxymethylpyridine

2-nitrooxymethylpyridine

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane In ethanol for 3h; Ambient temperature;84%
C15H16Cl2N2O

C15H16Cl2N2O

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With methanesulfonic acid In [D3]acetonitrile at 20℃; for 24h; Molecular sieve;84%
1,2-di(pyridin-2-yl)ethane-1,2-dio
1141-05-5

1,2-di(pyridin-2-yl)ethane-1,2-dio

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With oxygen; cetyltrimethylammonim bromide In water at 20℃; under 760.051 Torr; for 5h; Irradiation; Green chemistry;83%
With lead(IV) acetate; benzene
With Na0274MnO2*6H2O; oxygen In butan-1-ol at 100℃; under 760.051 Torr; for 1h; Green chemistry;99 %Chromat.
2-iodopyridine
5029-67-4

2-iodopyridine

formic acid
64-18-6

formic acid

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
Stage #1: 2-iodopyridine; formic acid With palladium diacetate; acetic anhydride; tricyclohexylphosphine In N,N-dimethyl-formamide at 30℃; for 1h; Inert atmosphere; Green chemistry;
Stage #2: With triethylamine In N,N-dimethyl-formamide at 80℃; for 6h; Inert atmosphere; Green chemistry;
83%
Stage #1: 2-iodopyridine With iodine; triethylamine; triphenylphosphine In dichloromethane; toluene at 20℃; for 0.0833333h; Sealed tube; Green chemistry;
Stage #2: formic acid In dichloromethane; toluene at 70℃; for 1.5h; Sealed tube; Green chemistry;
80%
With 1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate; dicyclohexyl-carbodiimide at 100℃; for 10h; Sealed tube;70%
With palladium diacetate; triethylamine; dicyclohexyl-carbodiimide; tricyclohexylphosphine In N,N-dimethyl-formamide at 60℃; for 10h; Inert atmosphere; Sealed tube;52%
(2-aminomethylpyridine)
3731-51-9

(2-aminomethylpyridine)

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With 1,4-bis(triphenylphosphonium)butane cerium nitrate In water; acetic acid for 0.583333h; Reflux;80%
Aufbewahren unter Luftzutritt;
With riboflavin tetraacetate In dimethylsulfoxide-d6; water-d2 for 0.166667h; Irradiation; In air;
2-bromo-pyridine
109-04-6

2-bromo-pyridine

carbon monoxide
201230-82-2

carbon monoxide

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With palladium diacetate; hydrogen; triphenylphosphine; 2,4,6-trimethyl-pyridine; tributyl-amine In acetonitrile at 120℃; under 22501.8 Torr; for 18h;80%
With 4-methoxy-N'-tetramethylethylenediamine; hydrogen; catacxium A; palladium diacetate In toluene at 100℃; under 3750.3 Torr; for 16h;7 % Chromat.
With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); sodium carbonate In N,N-dimethyl-formamide; 1,3,5-trimethyl-benzene at 90℃; under 2250.23 Torr; for 18h; Sealed tube;100 %Chromat.
pyridin-2-yl trifluoromethanesulfonate
65007-00-3

pyridin-2-yl trifluoromethanesulfonate

carbon monoxide
201230-82-2

carbon monoxide

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With palladium diacetate; hydrogen; triphenylphosphine; 2,4,6-trimethyl-pyridine; tributyl-amine In acetonitrile at 120℃; under 22501.8 Torr; for 18h;80%
α-picoline
109-06-8

α-picoline

2-(1H-pyrrol-1-yl)aniline
6025-60-1

2-(1H-pyrrol-1-yl)aniline

A

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

B

2-(pyridin-2-yl)pyrrolo[1,2-a]quinoxaline

2-(pyridin-2-yl)pyrrolo[1,2-a]quinoxaline

Conditions
ConditionsYield
With oxygen; copper diacetate; trifluoroacetic acid In N,N-dimethyl-formamide at 120℃; for 1h;A 10%
B 78%
2-[(ethylsulfanyl)methyl]pyridine
35250-74-9

2-[(ethylsulfanyl)methyl]pyridine

A

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

B

2-ethanesulfinylmethyl-pyridine

2-ethanesulfinylmethyl-pyridine

Conditions
ConditionsYield
With oxygen; rose bengal In methanol for 0.166667h; Oxidation; Irradiation;A 3%
B 74%
2-pyridine
219879-85-3

2-pyridine

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Conditions
ConditionsYield
With trifluoroacetic acid In water; acetonitrile at 20℃; for 3h;73%
(2-Styrylpyridin-3-yl)carbamic acid 2-bis(2-trimethylsilylethyl)phosphonooxy-5-chlorobenzyl ester

(2-Styrylpyridin-3-yl)carbamic acid 2-bis(2-trimethylsilylethyl)phosphonooxy-5-chlorobenzyl ester

2-[(E)-2-phenylethenyl]pyridine
538-49-8

2-[(E)-2-phenylethenyl]pyridine

A

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

B

(2-Formylpyridin-3-yl)carbamic acid 2-bis(2-trimethylsilylethyl)phosphonooxy-5-chlorobenzyl ester
412318-66-2

(2-Formylpyridin-3-yl)carbamic acid 2-bis(2-trimethylsilylethyl)phosphonooxy-5-chlorobenzyl ester

Conditions
ConditionsYield
With dimethylsulfide; nitrogen In ethanol; dichloromethaneA 72%
B n/a
2-vinylpyridine
100-69-6

2-vinylpyridine

A

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

B

2-oxiranylpyridine
55967-94-7

2-oxiranylpyridine

Conditions
ConditionsYield
With 1H-imidazole; sodium periodate; MnCl-TPP-(PEO750)4 In water; acetonitrile at 80℃; for 24h;A 25%
B 70%
2-Hydroxymethylpyridine
586-98-1

2-Hydroxymethylpyridine

diethylazodicarboxylate
1972-28-7

diethylazodicarboxylate

A

pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

B

diethyl hydrazodicarboxylate
4114-28-7

diethyl hydrazodicarboxylate

Conditions
ConditionsYield
With zinc dibromide In toluene for 2.5h; Reflux;A 70%
B n/a
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

benzoic acid hydrazide
613-94-5

benzoic acid hydrazide

2-pyridyl carboxaldehyde benzoylhydrazone (E-isomer)
1215-55-0

2-pyridyl carboxaldehyde benzoylhydrazone (E-isomer)

Conditions
ConditionsYield
In ethanol for 6h; Reflux;100%
With acetic acid In ethanol for 3h; Reflux;87%
With hydrogenchloride In ethanol at 20℃; for 0.5h; Condensation;85%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

phenylhydrazine
100-63-0

phenylhydrazine

(E)-1-(2-pyridinyl)methylene-2-phenylhydrazine
30915-38-9

(E)-1-(2-pyridinyl)methylene-2-phenylhydrazine

Conditions
ConditionsYield
In ethanol for 6h; Reflux;100%
With acetic acid In ethanol for 3h; Reflux;91%
With 1-deoxy-1-(methylamino)-D-glucitol In ethanol; water at 20℃; for 0.666667h; Green chemistry;85%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

(S)-valinol
2026-48-4

(S)-valinol

(S,E)-3-methyl-2-(pyridin-2-ylmethyleneamino)butan-1-ol
149197-27-3

(S,E)-3-methyl-2-(pyridin-2-ylmethyleneamino)butan-1-ol

Conditions
ConditionsYield
In benzene for 2h; Condensation; Heating;100%
With NaSO4 In benzene Ambient temperature; Yield given;
With magnesium sulfate In dichloromethane for 2h; Yield given;
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

2-Hydroxybenzylamine
932-30-9

2-Hydroxybenzylamine

2-Pyridin-2-yl-3,4-dihydro-2H-benzo[e][1,3]oxazine
134777-97-2

2-Pyridin-2-yl-3,4-dihydro-2H-benzo[e][1,3]oxazine

Conditions
ConditionsYield
In ethanol for 2h; Ambient temperature;100%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

u-2-amino-1-phenylpropan-1-ol
14838-15-4

u-2-amino-1-phenylpropan-1-ol

2-((4S,5R)-4-Methyl-5-phenyl-oxazolidin-2-yl)-pyridine
134778-00-0, 134778-01-1, 134876-45-2, 134876-46-3

2-((4S,5R)-4-Methyl-5-phenyl-oxazolidin-2-yl)-pyridine

Conditions
ConditionsYield
In ethanol for 2h; Ambient temperature; Further byproducts given;100%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

(1S,2S)-2-amino-1-phenylpropanol
492-39-7

(1S,2S)-2-amino-1-phenylpropanol

(1S,2S)-1-Phenyl-2-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-propan-1-ol

(1S,2S)-1-Phenyl-2-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-propan-1-ol

Conditions
ConditionsYield
In benzene for 2h; Condensation; Heating;100%
With magnesium sulfate In methanol at 50℃; for 1h;
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

Norpseudoephedrine
37577-07-4

Norpseudoephedrine

2-((4R,5R)-4-Methyl-5-phenyl-oxazolidin-2-yl)-pyridine
134778-00-0, 134778-01-1, 134876-45-2, 134876-46-3

2-((4R,5R)-4-Methyl-5-phenyl-oxazolidin-2-yl)-pyridine

Conditions
ConditionsYield
In ethanol for 2h; Ambient temperature; Further byproducts given;100%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

4-methoxy-aniline
104-94-9

4-methoxy-aniline

(E)-N-(4-methoxyphenyl)-1-(pyridin-2-yl)methanimine
26930-67-6, 42910-70-3

(E)-N-(4-methoxyphenyl)-1-(pyridin-2-yl)methanimine

Conditions
ConditionsYield
In toluene at 20℃; for 24h;100%
With magnesium sulfate In benzene for 20h; Ambient temperature;98%
With magnesium sulfate In ethanol at 25℃; for 16h;91%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

2-Amino-2-methyl-1-propanol
124-68-5

2-Amino-2-methyl-1-propanol

4,4-dimethyl-2-pyridin-2-yl-1,3-oxazolidine
134777-99-4

4,4-dimethyl-2-pyridin-2-yl-1,3-oxazolidine

Conditions
ConditionsYield
In ethanol for 2h; Ambient temperature;100%
In ethanol at 20℃; for 3h;94%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

ethylenediamine
107-15-3

ethylenediamine

N,N'-bis(2-pyridylmethyl)ethylenediamine
4608-34-8

N,N'-bis(2-pyridylmethyl)ethylenediamine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol under 2585.74 Torr; for 24h;100%
Stage #1: pyridine-2-carbaldehyde; ethylenediamine In methanol for 5h; Reflux;
Stage #2: With sodium tetrahydroborate In methanol Reflux;
86%
Stage #1: pyridine-2-carbaldehyde; ethylenediamine In methanol at 0℃; for 1h;
Stage #2: With sodium tetrahydroborate In methanol for 1h;
85%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

acrylonitrile
107-13-1

acrylonitrile

(+/-)-2-[(hydroxy)(pyridin-2-yl)methyl]acrylonitrile
153274-57-8

(+/-)-2-[(hydroxy)(pyridin-2-yl)methyl]acrylonitrile

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane at 0℃; for 0.5h; Morita-Baylis-Hillman reaction;100%
With 1,4-diaza-bicyclo[2.2.2]octane In neat (no solvent) at 0℃; for 0.5h; Catalytic behavior; Solvent; Time; Temperature; Morita-Baylis-Hillman Alkylation;100%
With 1,4-diaza-bicyclo[2.2.2]octane at 80℃; for 0.5h; Morita-Baylis-Hillman Alkylation; Microwave irradiation;100%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

2-(hydroxy-pyridin-2-yl-methyl)-acrylic acid methyl ester
118488-74-7

2-(hydroxy-pyridin-2-yl-methyl)-acrylic acid methyl ester

Conditions
ConditionsYield
With 1,4-diaza-bicyclo[2.2.2]octane In 1,4-dioxane; water at 20℃; for 1h; Baylis-Hillman reaction;100%
With 1,4-diaza-bicyclo[2.2.2]octane at 0℃; for 5h; Morita-Baylis-Hillman Alkylation;100%
With 1,4-diaza-bicyclo[2.2.2]octane at 80℃; for 0.166667h; Baylis-Hillman reaction; Microwave irradiation; neat (no solvent);99%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

aniline
62-53-3

aniline

2-(phenyliminomethyl)pyridine
7032-25-9

2-(phenyliminomethyl)pyridine

Conditions
ConditionsYield
In toluene at 20℃; for 24h; Inert atmosphere;100%
In toluene for 24h; Reflux;98%
In water at 25℃; for 3h; Inert atmosphere;95%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

propan-1-ol-3-amine
156-87-6

propan-1-ol-3-amine

tetrahydro-2-(2-pyridinyl)-2H-1,3-oxazine
134777-96-1

tetrahydro-2-(2-pyridinyl)-2H-1,3-oxazine

Conditions
ConditionsYield
In ethanol for 2h; Product distribution; Ambient temperature; other aminoalcohols, other pyridinecarbaldehydes;100%
In ethanol for 2h; Ambient temperature;100%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

benzylamine
100-46-9

benzylamine

1-phenyl-N-(pyridin-2-ylmethylene)methanamine
19198-87-9

1-phenyl-N-(pyridin-2-ylmethylene)methanamine

Conditions
ConditionsYield
for 6h; Kinetics; Molecular sieve; Reflux;100%
With sodium sulfate In tetrahydrofuran at 20℃;84%
With formic acid In neat (no solvent) at 20℃;80%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

ethyl (triphenylphosphoranylidene)acetate
1099-45-2

ethyl (triphenylphosphoranylidene)acetate

(E)-ethyl 3-(2-pyridyl)-propenoate
7340-23-0, 33788-40-8, 70526-11-3

(E)-ethyl 3-(2-pyridyl)-propenoate

Conditions
ConditionsYield
In tetrahydrofuran for 24h;100%
In dichloromethane for 26h; Wittig reaction; Heating;93%
In ethanol at 80℃; Wittig Olefination;80%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

2-Hydroxymethylpyridine
586-98-1

2-Hydroxymethylpyridine

Conditions
ConditionsYield
With 1-Benzyl-3,5-bis(1-pyrrolidinylcarbonyl)-1,4-dihydropyridine; zinc(II) perchlorate; anionic SDS micelle In water at 50℃; Rate constant; different Zn(ClO4)2*6H2O concentration, in the presence and without of SDS;100%
With magnesium(II) perchlorate; polymer-bound NADH (2a) In acetonitrile; benzene at 80℃; for 120h; Further byproducts given;100%
With 1-Benzyl-3,5-bis(1-pyrrolidinylcarbonyl)-1,4-dihydropyridine; zinc(II) perchlorate; anionic SDS (C12H25OSO3Na) micelle In water at 50℃;100%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

2-pyridinealdoxime
873-69-8

2-pyridinealdoxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium acetate In ethanol at 60℃; for 2h;100%
Stage #1: pyridine-2-carbaldehyde With hydroxylamine hydrochloride In ethanol; water at 20℃; for 0.0166667h; Sealed tube;
Stage #2: In ethanol; water at 120℃; for 1h; Sealed tube; Microwave irradiation;
98%
With hydroxylamine hydrochloride; sodium hydroxide In ethanol; water at 50℃; for 2h;93.4%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

methylmagnesium bromide
75-16-1

methylmagnesium bromide

Conditions
ConditionsYield
In diethyl ether at 0℃; for 2h;100%
In diethyl ether at 0 - 5℃; for 2h; Inert atmosphere;61%
Yield given;
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

2,2',2''-triaminotriethylamine
4097-89-6

2,2',2''-triaminotriethylamine

N'-(pyridin-2-ylmethyl)-N,N-bis{2-[(pyridin-2-ylmethyl)amino]ethyl}ethane-1,2-diamine
122329-11-7

N'-(pyridin-2-ylmethyl)-N,N-bis{2-[(pyridin-2-ylmethyl)amino]ethyl}ethane-1,2-diamine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol under 2585.74 Torr; for 24h;100%
With hydrogen; palladium on activated charcoal In methanol under 760 Torr; for 12h; Ambient temperature;89%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

(S,S)-1,2-diphenyl-1,2-diaminoethane
29841-69-8

(S,S)-1,2-diphenyl-1,2-diaminoethane

(1S,2S)-N,N'-bis(2-pyridylmetheno)-1,2-diphenylethylenediimine

(1S,2S)-N,N'-bis(2-pyridylmetheno)-1,2-diphenylethylenediimine

Conditions
ConditionsYield
In benzene for 2h; Heating;100%
In methanol22%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

(R)-1-phenyl-ethyl-amine
3886-69-9

(R)-1-phenyl-ethyl-amine

(R,E)-N-(1-phenylethyl)-1-(pyridin-2-yl)methanimine
38010-70-7

(R,E)-N-(1-phenylethyl)-1-(pyridin-2-yl)methanimine

Conditions
ConditionsYield
In toluene Reflux; Inert atmosphere; Dean-Stark;100%
With magnesium sulfate In diethyl ether for 4h; Ambient temperature;90%
With aluminum oxide
In diethyl ether for 1h; Molecular sieve; Inert atmosphere;
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

1,5-diamino-3-azapentane
111-40-0

1,5-diamino-3-azapentane

N-pyridin-2-ylmethyl-N'-{2-[(pyridin-2-ylmethyl)amino]ethyl}ethane-1,2-diamine
58214-73-6

N-pyridin-2-ylmethyl-N'-{2-[(pyridin-2-ylmethyl)amino]ethyl}ethane-1,2-diamine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol under 2585.74 Torr; for 24h;100%
Stage #1: pyridine-2-carbaldehyde; 3-azapentane-1,5-diamine In ethanol at 50℃; for 2h; Inert atmosphere;
Stage #2: With sodium tetrahydroborate In ethanol at 50℃; for 2h; Inert atmosphere; chemoselective reaction;
92%
Stage #1: pyridine-2-carbaldehyde; 3-azapentane-1,5-diamine With acetic acid; zinc In methanol at 70 - 80℃; for 4.5h;
Stage #2: With hydrogenchloride In methanol at 20℃;
Stage #3: With sodium hydroxide In water
85%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

N-methyl-ethane-1,2-diamine
109-81-9

N-methyl-ethane-1,2-diamine

N1-methyl-N2-(pyridin-2-ylmethyl)ethane-1,2-diamine
63671-67-0

N1-methyl-N2-(pyridin-2-ylmethyl)ethane-1,2-diamine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In methanol under 2585.74 Torr; for 24h;100%
Stage #1: pyridine-2-carbaldehyde; N-methyl-ethane-1,2-diamine In methanol
Stage #2: With sodium tetrahydroborate In methanol for 24h;
70%
Stage #1: pyridine-2-carbaldehyde; N-methyl-ethane-1,2-diamine In methanol at 20℃; for 24h;
Stage #2: With sodium tetrahydroborate In methanol at 20℃; for 24h;
30%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

(S)-2-amino-1,1-diphenyl-4-methylpentan-1-ol
78603-97-1

(S)-2-amino-1,1-diphenyl-4-methylpentan-1-ol

(S)-4-Methyl-1,1-diphenyl-2-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-pentan-1-ol

(S)-4-Methyl-1,1-diphenyl-2-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-pentan-1-ol

Conditions
ConditionsYield
In benzene for 2h; Condensation; Heating;100%
In benzene Heating;
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

(S)-(-)-2-amino-1,1,3-triphenyl-1-propanol
79868-78-3

(S)-(-)-2-amino-1,1,3-triphenyl-1-propanol

(S)-1,1,3-Triphenyl-2-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-propan-1-ol

(S)-1,1,3-Triphenyl-2-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-propan-1-ol

Conditions
ConditionsYield
In benzene for 2h; Condensation; Heating;100%
In benzene Heating;
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

1,1-diphenyl-L-valinol
78603-95-9

1,1-diphenyl-L-valinol

(S)-3-Methyl-1,1-diphenyl-2-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-butan-1-ol

(S)-3-Methyl-1,1-diphenyl-2-{[1-pyridin-2-yl-meth-(E)-ylidene]-amino}-butan-1-ol

Conditions
ConditionsYield
In benzene for 2h; Condensation; Heating;100%
In benzene Heating;
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

(2-aminomethylpyridine)
3731-51-9

(2-aminomethylpyridine)

(E)-1-(pyridine-2-yl)-N-(pyridine-2-ylmethylene)methaneamine
119715-60-5

(E)-1-(pyridine-2-yl)-N-(pyridine-2-ylmethylene)methaneamine

Conditions
ConditionsYield
With magnesium sulfate In dichloromethane at 20℃; for 3h;100%
In dichloromethane at 20℃; for 12h; Molecular sieve;98%
In ethanol
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

aniline
62-53-3

aniline

(E)-N-(2-pyridylmethylene)aniline
7032-25-9, 40468-86-8, 88785-71-1

(E)-N-(2-pyridylmethylene)aniline

Conditions
ConditionsYield
In toluene at 20℃; for 24h;100%
In tert-Amyl alcohol at 20℃; for 24h; Inert atmosphere;100%
With magnesium sulfate In dichloromethane at 20℃; for 24h;99%
pyridine-2-carbaldehyde
1121-60-4

pyridine-2-carbaldehyde

1-amino-3-(dimethylamino)propane
109-55-7

1-amino-3-(dimethylamino)propane

(E)-N1,N1-dimethyl-N3-(pyridin-2-ylmethylene)propane-1,3-diamine

(E)-N1,N1-dimethyl-N3-(pyridin-2-ylmethylene)propane-1,3-diamine

Conditions
ConditionsYield
With sodium carbonate In ethanol for 72h;100%
In methanol

1121-60-4Related news

Synthesis, spectroscopy and X-ray crystal structures of some zinc(II) and cadmium(II) complexes of the 2-Pyridinecarboxaldehyde (cas 1121-60-4) Schiff bases of S-methyl- and S-benzyldithiocarbazates09/29/2019

The Schiff bases formed by condensation of S-methyl- and S-benzyldithiocarbazate with 2-pyridinecarboxaldehyde react with zinc(II) and cadmium(II) acetates to form stable metal complexes of general formulas, [Zn(NNS)(CH3COO)]2 and [M(NNS)2] (M = Zn2+, Cd2+; NNS− = anionic forms of the 2-pyridine...detailed

Theoretical and experimental comparative study of a derivative from 2-Pyridinecarboxaldehyde (cas 1121-60-4) which exhibits configurational dynamics09/28/2019

The (E)-4-nitro-N′-(pyridine-2-ylmethylene)benzohydrazide, a derivative from 2-pyridinecarboxaldehyde, displays E/Z isomerization induced by ultraviolet radiation in which the process of photoisomerization was evidenced and followed by 1D 1H NMR. The structure of the compound was determined by ...detailed

N-terminal specific conjugation of extracellular matrix proteins to 2-Pyridinecarboxaldehyde (cas 1121-60-4) functionalized polyacrylamide hydrogels10/01/2019

Polyacrylamide hydrogels have been used extensively to study cell responses to the mechanical and biochemical properties of extracellular matrix substrates. A key step in fabricating these substrates is the conjugation of cell adhesion proteins to the polyacrylamide surfaces, which typically inv...detailed

Research paperNovel 2-Pyridinecarboxaldehyde (cas 1121-60-4) thiosemicarbazones Ga(III) complexes with a high antiproliferative activity by promoting apoptosis and inhibiting cell cycle09/27/2019

Two types of 2-pyridinecarboxaldehyde thiosemicarbazones Ga(III) complexes, which are 2:1 and 1:1 ligand/Ga(III) complexes, were synthesized and determined by X-ray single crystal diffraction. The antiproliferative activity of these Ga(III) complexes have been examined to illuminate the structur...detailed

Synthesis, characterization, fluorescence and catalytic activity of some new complexes of unsymmetrical Schiff base of 2-Pyridinecarboxaldehyde (cas 1121-60-4) with 2,6-diaminopyridine09/24/2019

The Schiff base, 2-[(pyridin-2-ylmethylidene)amino]-6-aminopyridine (L) was synthesized by 1:1 condensation of 2-pyridinecarboxaldehyde and 2,6-diaminopyridine. The ligand and its complexes were characterized by different physicochemical studies. The analytical and spectroscopic tools indicated ...detailed

1121-60-4Relevant articles and documents

Solution Dynamics of Hybrid Anderson-Evans Polyoxometalates

Salazar Marcano, David E.,Lentink, Sarah,Moussawi, Mhamad A.,Parac-Vogt, Tatjana N.

, p. 10215 - 10226 (2021)

Understanding the stability and speciation of metal-oxo clusters in solution is essential for many of their applications in different areas. In particular, hybrid organic-inorganic polyoxometalates (HPOMs) have been attracting increasing attention as they combine the complementary properties of organic ligands and metal-oxygen nanoclusters. Nevertheless, the speciation and solution behavior of HPOMs have been scarcely investigated. Hence, in this work, a series of HPOMs based on the archetypical Anderson-Evans structure, δ-[MnMo6O18{(OCH2)3C-R}2]3-, with different functional groups (R = -NH2, -CH3, -NHCOCH2Cl, -NCH(2-C5H4N) {pyridine; -Pyr}, and -NHCOC9H15N2OS {biotin; -Biot}) and countercations (tetrabutylammonium {TBA}, Li, Na, and K) were synthesized, and their solution behavior was studied in detail. In aqueous solutions, decomposition of HPOMs into the free organic ligand, [MoO4]2-, and free Mn3+ was observed over time and was shown to be highly dependent on the pH, temperature, and nature of the ligand functional group but largely independent of ionic strength or the nature of the countercation. Furthermore, hydrolysis of the amide and imine bonds often present in postfunctionalized HPOMs was also observed. Hence, HPOMs were shown to exhibit highly dynamic behavior in solution, which needs to be carefully considered when designing HPOMs, particularly for biological applications.

-

Papadopoulos et al.

, p. 615 (1966)

-

-

Newkome et al.

, p. 410 (1974)

-

Copper-catalyzed selective oxygenation of methyl and benzyl substituents in pyridine with O2

Abe, Tsukasa,Tanaka, Shinji,Ogawa, Atsuko,Tamura, Masanori,Sato, Kazuhiko,Itoh, Shinobu

, p. 348 - 350 (2017)

A selective oxygenation of picolines and their derivatives has been achieved by usingasimple copper salt as a catalyst and molecular oxygen as an oxidant, where the α-position of the alkyl substituent is selectively oxidized to give the corresponding aldehydes or ketones. Addition of a catalytic amount of water enhances the catalytic activity, which could be attributed to the role of the proton donor to activate the substrates.

-

Lejtis,Simanskaja

, (1969)

-

Improving the reactivity of hydrazine-bearing MRI probes for: In vivo imaging of lung fibrogenesis

Akam, Eman A.,Abston, Eric,Rotile, Nicholas J.,Slattery, Hannah R.,Zhou, Iris Y.,Lanuti, Michael,Caravan, Peter

, p. 224 - 231 (2020)

Pulmonary fibrosis (PF) is the pathologic accumulation of extracellular matrix components in lung tissue that result in scarring following chronic lung injury. PF is typically diagnosed by high resolution computed tomography (HRCT) and/or invasive biopsy. However, HRCT cannot distinguish old injury from active fibrogenesis. We previously demonstrated that allysine residues on oxidized collagen represent an abundant target during lung fibrogenesis, and that magnetic resonance imaging (MRI) with a small-molecule, gadolinium-containing probe, Gd-Hyd, could specifically detect and stage fibrogenesis in a mouse model. In this work, we present an improved probe, Gd-CHyd, featuring an N,N-dialkyl hydrazine which has an order of magnitude both greater reactivity and affinity for aldehydes. In a paired study in mice with bleomycin induced lung injury we show that the improved reactivity and affinity of Gd-CHyd results in significantly higher lung-to-liver contrast, e.g. 77% higher at 45 min post injection, and slower lung clearance than Gd-Hyd. Gd-CHyd enhanced MRI is >60-fold higher in bleomycin injured mouse lungs compared to uninjured mice. Collectively, our data indicate that enhancing hydrazine reactivity and affinity towards allysine is an effective strategy to significantly improve molecular MRI probes for lung fibrogenesis.

The Synergy Effect in Tio2 Supported Bi-Mo Catalysts for Facile and Environmentally-Friendly Synthesis of Pyridylaldehydes from Oxidation of Picolines

Dai, Liyan,Jie, Yu,Zhylko, Viachaslau

, p. 181 - 186 (2020)

Abstract: The oxidation of picolines to pyridlaldehydes was studied over bismuth molybdate catalysts supported on TiO2. The research results showed that α-Bi2Mo3O12 was superior to β-Bi2Mo2O9 and γ-Bi2MoO6 in terms of reactivity. Further doping MoO3 to α-Bi2Mo3O12/TiO2 gave rise to increased catalytic performance, which was due to the synergy effect of α-Bi2Mo3O12 and MoO3. The effect was on one hand manifested in the intimate relationship between α-Bi2Mo3O12 and MoO3 in stabilizing the crystallographic structure of catalysts and thereafter maintaining the surface area of the catalyst, as indicated by the BET surface area and XRD analysis. Moreover, NH3-TPD analysis demonstrated the effect in modifying the surface acidity of the catalysts, and thus facilitating the substrate adsorption as the picolines are alkaline substances. Additionally, the effect between α-Bi2Mo3O12 and MoO3 rendered the modification of the electronic properties and thereafter the oxygen desorption properties and reducible properties of the catalysts, as evidenced in the H2-TPR and O2-TPD analysis.

An Optical Resolution of Pyridyl and Bipyridylethanols and A Facile Preparation of Optically Pure Oligopyridines

Uenishi, Jun'ichi,Nishiwaki, Kenji,Hata, Shinichiro,Nakamura, Kaoru

, p. 7973 - 7976 (1994)

A kinetic resolution of racemic pyridyl and bipyridylethanols was performed by Candida antarctica lipase with vinyl acetate in diisopropyl ether, in which (R)-alcohol was acetylated stereoselectively, and both the acetate 2 and the remaining (S)-alcohol 1 were obtained with high enantiomeric excesses. (S)-Oligopyridylethanols, 7 and 8 were prepared by a coupling reaction of (S)-1b and (S)-1e with ethyl bipyridyl sulfoxide.

Hydroxyl radical-mediated oxidative cleavage of CC bonds and further esterification reaction by heterogeneous semiconductor photocatalysis

Hong, Mei,Jia, Rui,Miao, Hongyan,Ni, Bangqing,Niu, Tengfei,Wang, Hui

, p. 6591 - 6597 (2021/09/10)

A hydroxyl radical-mediated aerobic cleavage of alkenes and further sequence esterification reaction for the preparation of carbonyl compounds have been developed by using tubular carbon nitride (TCN) as a general heterogeneous photocatalyst under an oxygen atmosphere with visible light irradiation. This protocol has an excellent substrate scope and gives the desired aldehydes, ketones and esters in moderate to high yields. Importantly, this metal-free procedure employed photogenerated hydroxyl radicals in situ as green oxidation active species, avoiding the present additional initiators. The reaction could be carried out under solar light irradiation and was applicable to large-scale reactions. Furthermore, the recyclable TCN catalyst could be used several times without a significant loss of activities.

Aryl aldiketone and synthesis method thereof

-

Paragraph 0020, (2021/09/26)

The invention discloses an aryl aldehyde ketone and a synthesis method thereof, wherein an aryl aldehyde is synthesized from cheap olefin as a raw material. A commercially available inexpensive olefin is used as a raw material, ether is used as an additive, molecular oxygen serves as a sole oxidizing agent, water is used as a solvent, and the aldehyde and ketone are synthesized by column chromatography under a photocatalytic condition. The invention has the advantages of mild reaction conditions, green and environmental protection, simple experimental operation, good reaction selectivity, high product yield and the like.

PhSe(O)OH/NHPI-catalyzed oxidative deoximation reaction using air as oxidant

Shi, Yaocheng,Wang, Feng,Yang, Chenggen,Yu, Lei

, (2021/09/06)

A novel oxidative deoximation method was developed in this article. Compared with the reported organoselenium-catalyzed oxidative deoximation reaction, this reaction employed N-hydroxyphthalimide (NHPI) as the co-catalyst, so that the oxidative deoximation reaction could utilize air as oxidant in the green DMC solvent under mild reaction conditions. Control experiments and X-ray photoelectron spectroscopy (XPS) analysis results indicated that NHPI was essential for activating the catalytic organoselenium species. It could accelerate the activation of molecular oxygen in air to promote the reaction process. The reaction can avoid metal residues in product and is of potential application values in pharmaceutical industry due to the transition metal-free process.

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