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Carbamic acid, (3-amino-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI), also known as tert-butyl 3-aminopyridine-2-carbamate, is an organic compound with the molecular formula C9H14N2O2. It is a tert-butyl ester derivative of carbamic acid and features a 3-amino-2-pyridinyl group, which endows it with potential pharmacological properties. Carbamic acid, (3-amino-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI) is primarily used as an intermediate in the synthesis of pharmaceutical drugs and is also utilized in the research and development of new pharmaceuticals and agrochemicals. However, due to its potential hazards and toxicity, it is crucial to handle this chemical with care.

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  • 108655-56-7 Structure
  • Basic information

    1. Product Name: Carbamic acid, (3-amino-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI)
    2. Synonyms: Carbamic acid, (3-amino-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI);tert-Butyl (3-aMinopyridin-2-yl)carbaMate;Tert-Butyl (3-Aminopyridin-2-Yl)Carbamate(WX606110)
    3. CAS NO:108655-56-7
    4. Molecular Formula: C10H15N3O2
    5. Molecular Weight: 209.245
    6. EINECS: N/A
    7. Product Categories: N-BOC
    8. Mol File: 108655-56-7.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 313.8±27.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.202±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. PKA: 12.16±0.70(Predicted)
    10. CAS DataBase Reference: Carbamic acid, (3-amino-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
    11. NIST Chemistry Reference: Carbamic acid, (3-amino-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI)(108655-56-7)
    12. EPA Substance Registry System: Carbamic acid, (3-amino-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI)(108655-56-7)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 108655-56-7(Hazardous Substances Data)

108655-56-7 Usage

Uses

Used in Pharmaceutical Industry:
Carbamic acid, (3-amino-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI) is used as a chemical intermediate for the synthesis of pharmaceutical drugs. Its unique structure and functional groups make it a valuable building block in the development of new medications with potential therapeutic applications.
Used in Agrochemical Research and Development:
In the agrochemical industry, Carbamic acid, (3-amino-2-pyridinyl)-, 1,1-dimethylethyl ester (9CI) is employed in the research and development of new agrochemicals. Its potential pharmacological properties can be harnessed to create innovative products for agricultural applications, such as pesticides or herbicides.

Check Digit Verification of cas no

The CAS Registry Mumber 108655-56-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,8,6,5 and 5 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 108655-56:
(8*1)+(7*0)+(6*8)+(5*6)+(4*5)+(3*5)+(2*5)+(1*6)=137
137 % 10 = 7
So 108655-56-7 is a valid CAS Registry Number.

108655-56-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-Butyl (3-aminopyridin-2-yl)carbamate

1.2 Other means of identification

Product number -
Other names tert-butyl N-(3-aminopyridin-2-yl)carbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:108655-56-7 SDS

108655-56-7Downstream Products

108655-56-7Relevant articles and documents

Synthesis and evaluation of novel GSK-3β inhibitors as multifunctional agents against Alzheimer's disease

Shi, Xiao-Long,Wu, Jing-De,Liu, Ping,Liu, Zhao-Peng

, p. 211 - 225 (2019)

To target the multi-facets of Alzheimer's disease (AD), a series of novel GSK-3β inhibitors containing the 2,3-diaminopyridine moiety were designed and synthesized. The amide derivatives 5a-f showed moderate potency against GSK-3β with weak Cu2+, Zn2+ and Al3+ chelating ability. The imine derivatives 9a, 9b and 9e were potent GSK-3β inhibitors and selective Cu2+and Al3+ chelators. The 1,2-diamine derivatives 10a-e were strong metal-chelators, but decreased or lost their GSK-3β inhibitory potency. In vitro, compounds 9a, 9b and 9e, especially 9b, exhibited good Cu2+-induced Aβ aggregation inhibition, Cu2+-Aβ complex disaggregation, ROS formation inhibition, and antioxidant activities. In cells, compounds 9a, 9b and 9e can inhibit tau protein phosphorylation and protect neuro cells against Cu2+-Aβ1–42 and H2O2-induced cell damage. Furthermore, compound 9b was predicted to have the ability to pass the BBB with drug likeness properties. Therefore, compound 9b might be a good lead for the development of novel GSK-3β inhibitors targeting multi-facets of AD.

SUBSTITUTED-QUINOXALINE-TYPE-PIPERIDINE COMPOUNDS AND THE USES THEREOF

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Page/Page column 169, (2009/04/25)

The invention relates to Substituted-Quinoxaline-Type Piperidine Compounds, compositions comprising an effective amount of a Substituted-Quinoxaline-Type Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administeri

HETEROCYCLIC-SUBSTITUTED PIPERDINE COMPOUNDS AND THE USES THEREOF

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Page/Page column 243, (2008/12/07)

The invention relates to Heterocyclic-Substituted Piperidine Compounds, compositions comprising an effective amount of a Heterocyclic-Substituted Piperidine Compound and methods to treat or prevent a condition, such as pain, comprising administering to an animal in need thereof an effective amount of a Heterocyclic-Substituted Piperidine Compound

Applications of 1-Alkoxycarbonyl- and 1-Acyl-v-triazolopyridines as Acylating Reagents

Torrini, Ines,Zecchini, Giampiero Pagani,Agrosi, Francesco,Paradisi, Mario Paglialunga

, p. 1459 - 1463 (2007/10/02)

Selective N-protection of hydroxyamino esters has been readily achieved using 1-alkoxycarbonyl- or 1-acyl-v-triazolopyridines.The amide-type triazolides reacted with alcohols in the presence of DBU at room temperature to afford in high yields the corresponding esters.The different reactivity of 1- and 3-alkoxycarbonyl derivatives of the title bicyclic system toward primary amines has been further investigated.

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