108896-77-1Relevant articles and documents
Synthesis and biological evaluation of novel substituted-imidazolidine derivatives
Husain, Asif,Bhutani, Rubina,Kumar, Deepak,Shin, Dong-Soo
, p. 227 - 233 (2013/07/26)
A series of newer substituted-imidazolidine derivatives 3a-k were synthesized and assayed in vivo to investigate their anti-inflammatory, analgesic and antiulcer activity. The results of biological evaluation revealed that the three compounds, 4-[1,3-bis(4-hydroxy-3-methoxybenzyl)-2- imidazolidinyl]phenyldiethylamine (3g), 4-[1,3-bis(3-Ethoxy-4-hydroxybenzyl)-2- imidazolidinyl] phenyldiethylamine (3h) and 4-(1,3-bis(benzo[d][1,3]dioxol-5- ylmethyl)-4-methylimidazolidin-2-yl)-N,N-diethylbenzenamine (3j) were good in their anti-inflammatory and analgesic actions. Additionally these derivatives showed superior GI safety profile as compared to that of the standard drug in terms of low severity index. The results are statistically treated for its significance.
Novel inhibitors for multidrug resistance: 1,3,5-Triazacycloheptanes
Sawanishi,Wakusawa,Murakami,Muramatsu,Suzuki,Takashima,Aizawa,Miyamoto
, p. 5066 - 5070 (2007/10/03)
1,3,5-Triazacycloheptanes were synthesized and examined for reversal of the multidrug resistance dependent on P-glycoprotein. Most of these compounds increased the intracellular uptake of vinblastine in multidrug-resistant mouse leukemia P388/ADR cells wi