108981-97-1

Basic information

• Product Name: benzyl 4-oxo-4H-chromene-2-carboxylate
• Synonyms: benzyl 4-oxo-4H-chromene-2-carboxylate
• CAS NO: 108981-97-1
• Molecular Formula: C₁₇H₁₂O₄
• Molecular Weight: 280.27478
• Mol File: 108981-97-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: benzyl 4-oxo-4H-chromene-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl 4-oxo-4H-chromene-2-carboxylate(108981-97-1)
• EPA Substance Registry System: benzyl 4-oxo-4H-chromene-2-carboxylate(108981-97-1)

Safety Data

• Hazardous Substances Data: 108981-97-1(Hazardous Substances Data)

Upstream product

• 37976-44-6 dibenzylacetylene dicarboxylate 
• 108-95-2 phenol 
• 118-93-4 o-hydroxyacetophenone 
• 4940-39-0 acide chromone carboxylique-2 
• 100-51-6 benzyl alcohol 

Relevant articles and documents

SYNTHESIS OF SMALL MOLECULES INSPIRED BY PHOMOXANTHONE A

Methods, compositions, and kits are provided for synthesizing bioactive chromane, the method including: constructing a tertiary ether stereocenter enantioselectively by catalyzed alkynylation of a substituted chromenone to obtain a chromanone; reducing alkyne and ketone in the chromanone to obtain a chroman; and converting ester to methyl group thereby obtaining chromane.

FeCl3 and ether mediated direct intramolecular acylation of esters and their application in efficient preparation of xanthone and chromone derivatives

The direct intramolecular acylation of esters was developed by using the combined system of FeCl3 with Cl2CHOCH3. This unique cooperative system offered a new and efficient approach to biologically important xanthone and chromone derivatives with regioselectivity. Examples were reported, and control experiments were carried out to examine the effect of the benzyl esters and Cl2CHOCH3.

Acaricidal activity of tonka bean extracts. Synthesis and structure-activity relationships of bioactive derivatives

The acaricidal effects of tonka bean, Dipterix odorata, extracts were investigated on Dermatophagoides pteronyssinus, the European house dust mite, and compared with benzyl benzoate as a standard acaricidal compound. A cyclohexane extract was the most effective, with an EC50 = 0.075 g/m2 after a 24 h period, as compared with benzyl benzoate (0.025 g/m2). Bioassay-guided fractionation of this extract led to the isolation of coumarin (1). Pharmacomodulation of this compound led us to test 20 analogues (2-21), which were either synthesized or purchased.