109012-24-0

Basic information

• Product Name: 1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLIC ACID
• Synonyms: 1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLIC ACID;1H-Imidazole-2-carboxylic acid, 1-methyl-4-nitro-
• CAS NO: 109012-24-0
• Molecular Formula: C₅H₅N₃O₄
• Molecular Weight: 171.11
• Mol File: 109012-24-0.mol

Chemical Properties

• Melting Point: 134-137℃
• Boiling Point: 455.6±37.0 °C(Predicted)
• Appearance: /
• Density: 1.72±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 2.70±0.37(Predicted)
• CAS DataBase Reference: 1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLIC ACID(109012-24-0)
• EPA Substance Registry System: 1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLIC ACID(109012-24-0)

Safety Data

• Hazardous Substances Data: 109012-24-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLIC ACID is used as an intermediate in the synthesis of imidazole-containing DNA minor groove binding oligopeptides. These oligopeptides are related to the antiviral antibiotic netropsin, which is effective against a range of viral infections.
Used in Antitumor Applications:
In the field of oncology, 1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLIC ACID is used to prepare distamycin derivatives. These derivatives exhibit antitumor activities and are being investigated for their potential in treating various types of cancer.
Different applications in different industries:
There are no specific applications mentioned in different industries for 1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLIC ACID in the provided materials. The uses mentioned are primarily focused on pharmaceutical applications.

Upstream product

• 120095-64-9 2,2,2-trichloro-1-(1-methyl-4-nitro-1H-imidazol-2-yl)ethan-1-one 
• 30148-21-1 ethyl 1-methyl-1H-imidazole-2-carboxylate 
• 109012-23-9 ethyl 1-methyl-4-nitroimidazole-2-carboxylate 

Downstream Products

• 109012-46-6 1-methyl-4-nitroimidazole-2-carboxylic acid chloride 
• 585525-12-8 4-amino-3-[(1-methyl-4-nitro-1H-imidazole-2-carbonyl)-amino]benzoic methyl ester 
• 179983-49-4 tert-butyl 4-nitro-N-methyl-1H-imidazole-2-carboxylate 

Relevant articles and documents

Facile dimer synthesis for DNA-binding polyamide ligands

(Equation Presented). Pyrrole-imidazole polyamide ligands are highly sequence specific synthetic DNA-binding ligands that bind with high affinity. To counter the synthetic difficulties associated with coupling the electron-rich heterocyclic acids to the electron-deficient nucleophilic imidazole amine, a novel approach is described for synthesis of Fmoc-protected dimers for solid-phase peptide synthesis (SPPS). This method produces the dimers in high yields, is broadly applicable to other heterocyclic-containing polyamides, and results in improved ligand yields and synthesis times.

THIAZOLE DERIVATIVE

Provided is a compound having an agonist action on GPR52, which is useful as a prophylactic or therapeutic drug for mental diseases such as schizophrenia and the like, and the like. A compound represented by the formula (I): wherein each symbol is as defi

Synthesis of Novel Imidazole-Containing DNA Minor Groove Binding Oligopeptides Related to the Antiviral Antibiotic Netropsin

Analysis of the structural and stereochemical requirements for the strict DNA base sequence recognition of (AT)4 and (AT)5 respectively for the oligopeptide minor groove binding agents netropsin and distamycin leads to proposals for the rational structure