109012-23-9

Basic information

• Product Name: Ethyl 1-methyl-4-nitroimidazole-2-carboxylate
• Synonyms: ethyl 1-Methyl-4-nitro-1H-iMidazole-2-carboxylate;1-Methyl-4-nitroiMidazole-2-carboxylic acid ethyl ester
• CAS NO: 109012-23-9
• Molecular Formula: C₇H₉N₃O₄
• Molecular Weight: 199.17
• Mol File: 109012-23-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 350.7 °C at 760 mmHg
• Flash Point: 165.9 °C
• Appearance: /
• Density: 1.42 g/cm³
• Vapor Pressure: 4.33E-05mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: 2-8°C
• PKA: -2.47±0.60(Predicted)
• CAS DataBase Reference: Ethyl 1-methyl-4-nitroimidazole-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 1-methyl-4-nitroimidazole-2-carboxylate(109012-23-9)
• EPA Substance Registry System: Ethyl 1-methyl-4-nitroimidazole-2-carboxylate(109012-23-9)

Safety Data

• Hazardous Substances Data: 109012-23-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 109012-23-9 differently. You can refer to the following data:
1. Ethyl 1-methyl-4-nitroimidazole-2-carboxylate
2. Terameprocol is a semi-synthetic lignan which inhibits the transcription of several inflammatory and oncogenic genes.

InChI:InChI=1/C7H9N3O4/c1-3-14-7(11)6-8-5(10(12)13)4-9(6)2/h4H,3H2,1-2H3

Upstream product

• 865998-46-5 4-nitro-1H-imidazole-2-carboxylic acid ethyl ester 
• 74-88-4 methyl iodide 
• 120095-64-9 2,2,2-trichloro-1-(1-methyl-4-nitro-1H-imidazol-2-yl)ethan-1-one 
• 141-52-6 sodium ethanolate 
• 30148-21-1 ethyl 1-methyl-1H-imidazole-2-carboxylate 
• 64-17-5 ethanol 
• 30148-23-3 2-trichloroacetyl-1-methylimidazole 

Downstream Products

• 1359164-23-0 4-benzamido-1-methylimidazole-2-carboxylic acid 
• 1359164-22-9 ethyl 4-benzamido-1-methylimidazole-2-carboxylate 
• 1359164-21-8 C₂₉H₃₇N₁₁O₄ 
• 1359164-20-7 C₂₇H₃₂N₁₀O₄ 
• 1359164-25-2 C₂₉H₃₅ClN₁₀O₄ 
• 535937-76-9 1-methyl-4-[2-(4-trifluoromethyl-phenylsulfanyl)ethoxycarbonylamino]-1H-imidazole-2-carboxylic Acid Ethyl Ester 
• 128293-63-0 ethyl 4-tert-butyloxycarbonylamino-1-methylimidazole-2-carboxylate 
• 128293-64-1 4-[(tert-butoxycarbonyl)amino]-1-methylimidazole-2-carboxylic acid 
• 142211-78-7 3-<1-methyl-4-<1-methyl-4-<1-methyl-4-(formylamino)pyrrole-2-carboxamido>imidazole-2-carboxamido>pyrrole-2-carboxamido>propionamidine hydrochloride 
• 109012-46-6 1-methyl-4-nitroimidazole-2-carboxylic acid chloride 
• 180258-48-4 4-(4-tert-Butoxycarbonylamino-butyrylamino)-1-methyl-1H-imidazole-2-carboxylic acid 
• 288625-59-2 ethyl 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylate 
• 179983-39-2 1-methyl-4-[p-bis(2-chloroethyl)aminobenzamido]-imidazole-2-carboxylic acid 
• 535937-85-0 1-methyl-4-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-1H-imidazole-2-carboxylic acid 

Relevant articles and documents

Solid phase synthesis of polyamides containing imidazole and pyrrole amino acids

The solid phase synthesis of sequence specific DNA binding polyamides containing N-methylimidazole (Im) and N-methylpyrrole (Py) amino acids is described. Two monomer building blocks, Boc-Py-OBt ester and Boc-Im acid, are prepared on a 50 g scale without column chromatography. Using commercially available Boc-β-alanine-Pam resin, cycling protocols were optimized to afford high stepwise coupling yields (>99%). Deprotection by aminolysis affords up to 100 mg quantities of polyamide. Solid phase methodology increases both the number and complexity of minor groove binding polyamides which can be synthesized and analyzed with regard to DNA binding affinity and sequence specificity. The solid phase synthesis of a representative eight-residue polyamide is reported.

HETEROCYCLYLAMIDE-SUBSTITUTED IMIDAZOLES

The invention relates to heterocyclylamide-substituted imidazoles and methods for the production of the same, to the use thereof for the treatment and/or prophylaxis of diseases, to the use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases, and especially to the use thereof as antiviral agents, especially against cytomegaloviruses.

Method for the synthesis of pyrrole and imidazole carboxamides on a solid support

The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.