109071-38-7Relevant articles and documents
Pyroacm Resin: An Acetamidomethyl Derived Resin for Solid Phase Synthesis of Peptides through Side Chain Anchoring of C-Terminal Cysteine Residues
Juvekar, Vinayak,Gong, Young Dae
, p. 836 - 839 (2016)
The design, synthesis and utilization of an efficient acetamidomethyl derived resin for the peptide synthesis is presented using established Fmoc and Boc protocols via side chain anchoring. Cleavage of the target peptide from the resin is performed using carboxymethylsulfenyl chloride under mild conditions which gave in situ thiol-sulfenyl protection of the cysteine residues. The utility of the resin is successfully demonstrated through applications to the syntheses of model peptides and natural products Riparin 1.1 and Riparin 1.2. (Chemical Equation Presented).
HALOSILANES IN THE SYNTHESIS OF N-(HALOMETHYL) DERIVATIVES OF LACTAMS, N-METHYLCARBOXAMIDES, AND IMIDES
Orlova, N.A.,Shipov, A.G.,Savost'yanova, I.A.,Baukov, Yu.I.
, p. 1875 - 1881 (2007/10/02)
Methods are proposed for the synthesis of N-(halomethyl) derivatives of lactams, N-methylcarboxamides, and imides with the use of the paraform-chlorotrimethylsilane system and the replacement of the trimethylsiloxy group by halogen and of halogen by halogen by the action of halotrimethylsilanes or acetyl bromide.The reactions of N-(chloromethyl)lactams with carboxylic anhydrides lead to N-(acyloxymethyl)lactams.
Photoreactions of Succinimides with an N-Acyl Group in the Side Chain. Synthesis and Stereochemistry of Tricyclic Pyrrolopyrazine Ring Systems
Takechi, Haruko,Tateuchi, Sumiko,Machida, Minoru,Nishibata, Yoshihiko,Aoe, Keiichi,et al.
, p. 3142 - 3152 (2007/10/02)
Photocyclization of succinimides with an N-acyl group in the side chain gave bi- and tricyclic pyrrolopyrazines, some of which were converted to tricyclic amines by reduction.The stereochemistry of pyrrolopyrazine derivatives is discussed on the basis of the results of X-ray analysis and carbon-13 nuclear magnetic resonance spectroscopy.Keywords - succinimide; photocyclization; pyrrolo-pyrazine; hydrogen abstraction; X-ray analysis; 13C-NMR spectrum; tricyclic diamine