109140-25-2

Basic information

• Product Name: 3-propylamino-5-hydroxychroman
• Synonyms: 3-propylamino-5-hydroxychroman
• CAS NO: 109140-25-2
• Molecular Formula: C15H23 N O2
• Molecular Weight: 0
• Mol File: 109140-25-2.mol

Chemical Properties

• Boiling Point: 372.9°Cat760mmHg
• Flash Point: 179.3°C
• Appearance: /
• Density: 1.08g/cm³
• Vapor Pressure: 4.34E-06mmHg at 25°C
• Refractive Index: 1.555
• CAS DataBase Reference: 3-propylamino-5-hydroxychroman(CAS DataBase Reference)
• NIST Chemistry Reference: 3-propylamino-5-hydroxychroman(109140-25-2)
• EPA Substance Registry System: 3-propylamino-5-hydroxychroman(109140-25-2)

Safety Data

• Hazardous Substances Data: 109140-25-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H23NO2/c1-3-8-16(9-4-2)12-10-13-14(17)6-5-7-15(13)18-11-12/h5-7,12,17H,3-4,8-11H2,1-2H3

Upstream product

• 110927-00-9 3-(Di-n-propylamino)-5-methoxychroman 
• 110927-03-2 (R)-3-amino-5-methoxy-3,4dihydro-2H-1-benzopyran 
• 92210-62-3 5-methoxy-3-nitro-2H-1-benzopyran 
• 137305-41-0 5-methoxy-3,4-dihydro-3-nitro-2H-1-benzopyran 
• 110927-02-1 5-methoxy-3,4-dihydro-3-diallylamino-2H-1-benzopyran 

Downstream Products

• 219724-35-3 5-(3-aminophenyl)-3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyran 

Relevant articles and documents

N,N-disubstituted aminomethyl benzofuran derivatives: Synthesis and preliminary binding evaluation

A series of new N-substituted 2,3-dihydro-2-aminomethyl-2H-1-benzofuran derivatives was prepared and evaluated for affinity at 5-HT(1A), 5-HT(2A), 5-HT(2C), 5-HT3, D2, and D3 receptors. Compound 9, 8-[4-[N-propyl-N-(7-hydroxy-2,3-dihydro-2H-1-benzofuran-2-yl)methyl]aminobutyl]-8-azaspiro[4,5]decane-7,9-dione, bound at 5-HT(1A) sites with nanomolar affinity (IC50=1.5nM) and high selectivity over 5-HT(2A), 5-HT(2C), 5-HT3, D2, and D3 receptors. Copyright (C) 1999 Elsevier Science Ltd.

3,4-Dihydro-3-amino-2H-1-benzopyran Derivatives as 5-HT1A Receptor Ligands and Potential Anxiolytic Agents. 1. Synthesis and Structure-Activity Relationship Studies

A series of 3,4-dihydro-3-amino-2H-1-benzopyran derivatives were prepared in order to determine the necessary structural requirements for good affinity for 5-HT1A receptors and high selectivity versus other receptors.Modifications of the extrac

Methoxy and hydroxy derivatives of 3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyrans: New synthesis and dopaminergic activity

The synthesis of methoxy and hydroxy derivatives of 3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyran from readily available or commercial o-hydroxybenzaldehydes is described in six steps. The enantiomers of 8-hydroxy-3,4-dihydro-3-(di-n-propyl-amino)-2H-1-benzopyran 1b have been resolved. It is shown that the compound (-)-1b is a mroe selective D-2 agonist, compared to apomorphine.

5-Oxy-substituted-3-aminochroman compounds, processes for their preparation, pharmaceutical compositions containing them and methods of treatment therewith

A compound of the formula wherein R1 is a saturated or unsaturated alkyl group having 1-5 carbon atoms or a phenylalkyl group, whereby the phenyl ring may be substituted or unsubstituted and the alkyl having 1-4 carbon atoms, R2 is hydrogen or an alkyl group having 1-5 carbon atoms, or R1 and R2 together form a 5- or 6-membered ring containing 1 or 2 heteroatoms selected from N, O and S, and enantiomers and physiologically acceptable salts thereof, processes for preparation of said compounds, pharmaceutical preparations containing said compounds, use of and method of treatment of disorders in CNS by using said compounds and intermediates.