1093191-92-4

Basic information

• Product Name: (E)-Methyl 4-(2-iodovinyl)benzoate
• CAS NO: 1093191-92-4
• Molecular Formula: C₂₀H₂₂N₂O₄*ClH
• Molecular Weight: 288
• Mol File: 1093191-92-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-Methyl 4-(2-iodovinyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-Methyl 4-(2-iodovinyl)benzoate(1093191-92-4)
• EPA Substance Registry System: (E)-Methyl 4-(2-iodovinyl)benzoate(1093191-92-4)

Safety Data

• Hazardous Substances Data: 1093191-92-4(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
(E)-Methyl 4-(2-iodovinyl)benzoate is used as a chemical reagent for the preparation of various drugs and pharmaceutical products. Its unique structure and reactive properties make it a valuable intermediate in the synthesis of complex organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, (E)-Methyl 4-(2-iodovinyl)benzoate is used as a key building block for the synthesis of other functionalized benzoate derivatives, which are essential components in the development of new drugs and medications.
Used in Medicinal Chemistry and Drug Design:
(E)-Methyl 4-(2-iodovinyl)benzoate is also utilized in the field of medicinal chemistry and drug design, where its pharmacophoric properties contribute to the discovery and development of novel therapeutic agents.

Upstream product

• 1093191-90-2 (2S,3R)-3-amino-2-tritylaminobutyric acid methyl ester 
• 782450-15-1 (2S,3R)-methyl 2-amino-3-azidobutanoate 
• 1093190-13-6 (2S,3R)-methyl 3-amino-2-((tert-butoxycarbonyl)amino)butanoate 
• 1093190-12-5 (2S,3R)-methyl 3-azido-2-((tert-butoxycarbonyl)amino)butanoate 
• 728878-00-0 2-(S)-amino-3-(R)-azidobutyric acid methyl ester hydrochloride 
• 728877-99-4 3-(R)-azido-2-(S)-(tritylamino)butyric acid methyl ester 
• 728877-98-3 (2S,3S)-methyl 3-hydroxy-2-(tritylamino)butanoate 
• 1093191-91-3 (2S,3R)-3-Fmoc-amino-2-tritylaminobutyric acid methyl ester 
• 1093190-14-7 (2S,3R)-2-Boc-amino-3-Fmoc-aminobutyric acid methyl ester 

Downstream Products

• 1219366-73-0 C₃₁H₂₉FN₂O₆ 
• 1219498-42-6 C₃₁H₃₆N₂O₆ 

Relevant articles and documents

Design, Synthesis, and Properties of a Potent Inhibitor of Pseudomonas aeruginosa Deacetylase LpxC

Over the past several decades, the frequency of antibacterial resistance in hospitals, including multidrug resistance (MDR) and its association with serious infectious diseases, has increased at alarming rates. Pseudomonas aeruginosa is a leading cause of nosocomial infections, and resistance to virtually all approved antibacterial agents is emerging in this pathogen. To address the need for new agents to treat MDR P. aeruginosa, we focused on inhibiting the first committed step in the biosynthesis of lipid A, the deacetylation of uridyldiphospho-3-O-(R-hydroxydecanoyl)-N-Acetylglucosamine by the enzyme LpxC. We approached this through the design, synthesis, and biological evaluation of novel hydroxamic acid LpxC inhibitors, exemplified by 1, where cytotoxicity against mammalian cell lines was reduced, solubility and plasma-protein binding were improved while retaining potent anti-pseudomonal activity in vitro and in vivo.

ORGANIC COMPOUNDS FOR APPLICATIONS IN BACTERIAL INFECTIONS TREATMENT

The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of human diseases.

ANTIBACTERIAL AGENTS

Antibacterial compounds of formula (I) are provided, as well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.