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Indol-5-ylsulfonyl chloride is an organic chemical compound with the molecular formula C8H6ClNO2S. It is a derivative of indole, a heterocyclic aromatic organic compound, and features a sulfonyl chloride functional group. indol-5-ylsulfonyl chloride is known for its reactivity and is commonly used in the synthesis of various organic compounds, particularly in the pharmaceutical and chemical industries.

1094209-33-2

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1094209-33-2 Usage

Uses

Used in Pharmaceutical Industry:
Indol-5-ylsulfonyl chloride is used as a reagent for the preparation of sulfonamide derivatives of benzylamine. These derivatives are of significant interest due to their potential applications in the treatment of central nervous system (CNS) diseases. The sulfonyl chloride group in indol-5-ylsulfonyl chloride plays a crucial role in the formation of these bioactive compounds, which can modulate various biological targets and pathways associated with CNS disorders.

Check Digit Verification of cas no

The CAS Registry Mumber 1094209-33-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,9,4,2,0 and 9 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1094209-33:
(9*1)+(8*0)+(7*9)+(6*4)+(5*2)+(4*0)+(3*9)+(2*3)+(1*3)=142
142 % 10 = 2
So 1094209-33-2 is a valid CAS Registry Number.

1094209-33-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name indol-5-ylsulfonyl chloride

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1094209-33-2 SDS

1094209-33-2Upstream product

1094209-33-2Downstream Products

1094209-33-2Relevant articles and documents

N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity

Abeywardane, Asitha,Caviness, Gary,Choi, Younggi,Cogan, Derek,Gao, Amy,Goldberg, Daniel,Heim-Riether, Alexander,Jeanfavre, Debra,Klein, Elliott,Kowalski, Jennifer A.,Mao, Wang,Miller, Craig,Moss, Neil,Ramsden, Philip,Raymond, Ernest,Skow, Donna,Smith-Keenan, Lana,Snow, Roger J.,Wu, Frank,Wu, Jiang-Ping,Yu, Yang

, p. 5277 - 5283 (2016/11/11)

Compound 1 ((4-amino-3,5-dichlorophenyl)-1-(4-methylpiperidin-1-yl)-4-(2-nitroimidazol-1-yl)-1-oxobutane-2-sulfonamido) was discovered to be a 690 nM antagonist of human CCR10 Ca2+flux. Optimization delivered (2R)-4-(2-cyanopyrrol-1-yl)-S-(1H-indol-4-yl)-1-(4-methylpiperidin-1-yl)-1-oxobutane-2-sulfonamido (eut-22) that is 300 fold more potent a CCR10 antagonist than 1 and eliminates potential toxicity, mutagenicity, and drug–drug-interaction liabilities often associated with nitroaryls and anilines. eut-22 is highly selective over other GPCR's, including a number of other chemokine receptors. Finally, eut-22 is efficacious in the murine DNFB model of contact hypersensitivity. The efficacy of this compound provides further evidence for the role of CCR10 in dermatological inflammatory conditions.

2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10

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Page/Page column 126-127, (2009/11/29)

This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2, R4. Ar and Het are as defined herein. The invention also relates to methods of using the compound of for

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