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Cyclopropanecarboxylic acid, 2-formyl-, ethyl ester, (1S-trans)- (9CI) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • Cyclopropanecarboxylic acid, 2-formyl-, ethyl ester, (1S-trans)- (9CI)

    Cas No: 109716-61-2

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  • 109716-61-2 Structure
  • Basic information

    1. Product Name: Cyclopropanecarboxylic acid, 2-formyl-, ethyl ester, (1S-trans)- (9CI)
    2. Synonyms: Cyclopropanecarboxylic acid, 2-formyl-, ethyl ester, (1S-trans)- (9CI)
    3. CAS NO:109716-61-2
    4. Molecular Formula: C7H10O3
    5. Molecular Weight: 142.1525
    6. EINECS: N/A
    7. Product Categories: CARBOXYLICESTER
    8. Mol File: 109716-61-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 240.7±0.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.247±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Cyclopropanecarboxylic acid, 2-formyl-, ethyl ester, (1S-trans)- (9CI)(CAS DataBase Reference)
    10. NIST Chemistry Reference: Cyclopropanecarboxylic acid, 2-formyl-, ethyl ester, (1S-trans)- (9CI)(109716-61-2)
    11. EPA Substance Registry System: Cyclopropanecarboxylic acid, 2-formyl-, ethyl ester, (1S-trans)- (9CI)(109716-61-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 109716-61-2(Hazardous Substances Data)

109716-61-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 109716-61-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,9,7,1 and 6 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 109716-61:
(8*1)+(7*0)+(6*9)+(5*7)+(4*1)+(3*6)+(2*6)+(1*1)=132
132 % 10 = 2
So 109716-61-2 is a valid CAS Registry Number.

109716-61-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-formyl-cyclopropanecarboxylic ethyl ester

1.2 Other means of identification

Product number -
Other names .ethyl 2-formyl-cyclopropanecarboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:109716-61-2 SDS

109716-61-2Relevant articles and documents

Chiral Cyclic Aliphatic Linkers as Building Blocks for Selective Dopamine D2or D3Receptor Agonists

Battiti, Francisco O.,Bonifazi, Alessandro,Katritch, Vsevolod,Newman, Amy Hauck,Zaidi, Saheem A.

supporting information, p. 16088 - 16105 (2021/11/16)

Linkers are emerging as a key component in regulating the pharmacology of bitopic ligands directed toward G-protein coupled receptors (GPCRs). In this study, the role of regio- and stereochemistry in cyclic aliphatic linkers tethering well-characterized primary and secondary pharmacophores targeting dopamine D2 and D3 receptor subtypes (D2R and D3R, respectively) is described. We introduce several potent and selective D2R (rel-trans-16b; D2R Ki = 4.58 nM) and D3R (rel-cis-14a; D3R Ki = 5.72 nM) agonists while modulating subtype selectivity in a stereospecific fashion, transferring D2R selectivity toward D3R via inversion of the stereochemistry around these cyclic aliphatic linkers [e.g., (-)-(1S,2R)-43 and (+)-(1R,2S)-42]. Pharmacological observations were supported with extensive molecular docking studies. Thus, not only is it an innovative approach to modulate the pharmacology of dopaminergic ligands described, but a new class of optically active cyclic linkers are also introduced, which can be used to expand the bitopic drug design approach toward other GPCRs.

Anhydrous Hydrogen Iodide-Mediated Reductive Indolization of in Situ-Generated Cyclopropyl Hydrazones

Fujioka, Hiroki,Takeda, Norihiko,Ueda, Masafumi,Yasui, Motohiro

supporting information, (2021/12/17)

Fischer-type indolization of N-aryl-C-cyclopropyl hydrazones generated in situ followed by chemoselective reduction using tert-butyl iodide as an anhydrous HI generator was developed. This protocol provides indoles bearing carboxylic acid derivative units. A series of control experiments indicated the HI-mediated formation and reduction of spirocyclopropyl indolenines. Anhydrous HI functions as a Br?nsted acid as well as a reducing agent, facilitating the successful conversion of unstable reaction intermediates and iodinated mixtures in equilibrium.

Photo/N-Heterocyclic Carbene Co-catalyzed Ring Opening and γ-Alkylation of Cyclopropane Enal

Dai, Lei,Ye, Song

supporting information, p. 986 - 990 (2020/02/28)

An unprecedented photo/NHC-co-catalyzed ring-opening C-C bond cleavage of cyclopropane enal and the following γ-alkylation with a halogenated compound via radicals were established, affording the corresponding γ-alkylated α,β-unsaturated esters in moderate to good yields.

Acid catalyzed reactions of α,β-unsaturated aldehydes and ethyl diazoacetate

Branstetter, Bryan,Hossain, M. Mahmun

, p. 221 - 223 (2007/10/03)

The formation of cyclopropanes from α,β-unsaturated aldehydes and diazo compounds has been a rather challenging goal due to the extremely reactive aldehyde starter. Herein, our group reports the first formation of ethyl 2-formyl-1-cyclopropanecarboxylate in 100% yield from the acid catalyzed reaction between acrolein and ethyl diazoacetate (EDA).

The direct preparation of functionalised cyclopropanes from allylic alcohols or α-hydroxyketones using tandem oxidation processes

McAllister, Graeme D.,Oswald, Magalie F.,Paxton, Richard J.,Raw, Steven A.,Taylor, Richard J.K.

, p. 6681 - 6694 (2007/10/03)

New manganese dioxide-mediated tandem oxidation processes (TOPs) have been developed, which facilitate the direct conversion of allylic alcohols and α-hydroxyketones into polysubstituted functionalised cyclopropanes. In the simplest version, the oxidation of an allylic alcohol is carried out in the presence of a stabilised sulfurane, and the intermediate α,β-unsaturated carbonyl compound undergoes in situ cyclopropanation. By using a combination of stabilised phosphorane and sulfurane, the direct conversion of allylic alcohols or α-hydroxyketones into functionalised cyclopropanes is achieved, with in situ cyclopropanation being followed by Wittig olefination, or vice versa. The application of these methods to a formal synthesis of the lignan (±)-picropodophyllone, and to novel analogues of the insecticide allethrin II, is described.

Tandem oxidation processes for the preparation of functionalized cyclopropanes

Oswald, Magalie F.,Raw, Steven A.,Taylor, Richard J. K.

, p. 3997 - 4000 (2007/10/03)

(Chemical Equation Presented) A novel manganese dioxide-mediated tandem oxidation process (TOP) has been developed which allows the direct conversion of allylic alcohols into cyclopropanes, the intermediate aldehydes being trapped in situ with a stabilized sulfur-ylide. This methodology has been applied successfully to a variety of allylic alcohols and to a formal synthesis of the simple, naturally occurring lignan, (±)-picropodophyllone.

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