- Hybrid materials based on novel 2D lanthanide coordination polymers covalently bonded to amine-modified SBA-15 and MCM-41: assembly, characterization, structural features, thermal and luminescence properties
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Three novel 2D coordination polymers [Tb2(μ4-L)2(μ-HL)(μ-HCOO)(DEF)]n (Tb-L), [Eu(μ4-L)(L)(H2O)2]n (Eu-L), and [Nd(μ4-L)(L)(H2O)2]sub
- Wang, Jun,Dou, Wei,Kirillov, Alexander M.,Liu, Weisheng,Xu, Cailing,Fang, Ran,Yang, Lizi
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Read Online
- A water-stable lanthanide coordination polymer as a multiresponsive luminescent sensor for Fe3+, Cr(vi) and 4-nitrophenol
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Constructing water stable lanthanide coordination polymers (Ln-CPs) is of great importance for practical applications in biological and environmental areas and necessary for systematic research on the relationship between the properties of Ln-CPs and stru
- Liu, Yan,Ma, Jingjing,Xu, Cong,Yang, Yang,Xia, Minfang,Jiang, Huie,Liu, Weisheng
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Read Online
- Rationally designed non-enzymatic fluorogenic 'turn-on' probe for uric acid
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Abstract The simple and cost-effective detection of uric acid in serum or urine is highly desirable as uric acid acts as a biomarker for various diseases. Herein, we report a rationally designed, non-enzymatic probe for the detection of uric acid in serum samples over a wide range of concentrations (lower: ~60 μM, higher: ~700 μM and normal: ~120-380 μM) with 'turn-on' fluorogenic behaviour.
- Pradhan, Tuhin,Maiti, Sukhendu,Kumar, Rajesh,Lee, Yun Hak,Kim, Jong Wan,Lee, Joung Hae,Kim, Jong Seung
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Read Online
- Functional Porphyrinic Metal–Organic Framework as a New Class of Heterogeneous Halogen-Bond-Donor Catalyst
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Biomimetic metal-organic frameworks have attracted great attention as they can be used as bio-inspired models, allowing us to gain important insights into how large biological molecules function as catalysts. In this work, we report the synthesis and utilization of such a metal-metalloporphyrin framework (MMPF) that is constructed from a custom-designed ligand as an efficient halogen bond donor catalyst for Diels–Alder reactions under ambient conditions. The implementation of fabricated halogen bonding capsule as binding pocket with high-density C?Br bonds enabled the use of halogen bonding to facilitate organic transformations in their three-dimensional cavities. Through combined experimental and computational studies, we showed that the substrate molecules diffuse through the pores of the MMPF, establishing a host-guest system via the C?Br???π interaction. The formation of halogen bonds is a plausible explanation for the observed boosted catalytic efficiency in Diels–Alder reactions. Moreover, the unique capability of MMPF highlights new opportunities in using artificial non-covalent binding pockets as highly tunable and selective catalytic materials.
- Chen, Yu-Sheng,Cheng, Qigan,Ma, Shengqian,Nafady, Ayman,Shan, Chuan,Wojtas, Lukasz,Zhang, Weijie,Zhang, X. Peter
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p. 24312 - 24317
(2021/10/04)
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- COMPOSITIONS AND METHODS RELATED TO MOLECULAR CONJUGATION
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The invention relates to activated Michael acceptor (AMA) compounds that can undergo conjugation with biomolecules containing Michael donor moieties, thereby providing plasma-stable antibody-drug conjugates (ADCs). Pharmaceutical compositions of the ADCs are disclosed as well. Also provided herein are a number of applications (e.g., therapeutic applications) in which the compositions are useful.
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Page/Page column 60; 61
(2021/06/11)
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- BIVALENT TARGETED CONJUGATES
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The invention provides conjugates that comprise a bivalent targeting moiety, a nucleic acid, and optional linking groups as well as synthetic intermediates and synthetic methods useful for preparing the conjugates, compositions comprising the bidentate targeting ligands and the conjugates, as well as methods for targeting therapeutic nucleic acids with the bidentate conjugates. The conjugates are useful to target therapeutic nucleic acids.
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Page/Page column 59; 60
(2020/05/28)
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- THERAPEUTIC METHODS
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The invention provides methods and compositions for delivering a nucleic acid to a cell or the cytosol of the target cell. The method includes contacting the cell with, 1) a membrane-destabilizing polymer; and 2) a nucleic acid conjugate. The nucleic acid conjugate includes a targeting ligand bound to an optional linker and a nucleic acid.
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Page/Page column 204; 231-232
(2020/05/28)
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- Optimized reaction pair of the Cyshis tag and Ni(II)-Nta probe for highly selective chemical labeling of membrane proteins
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Chemical labeling of proteins with synthetic molecular probes offers the possibility to probe the functions of proteins of interest in living cells. However, the methods for covalently labeling targeted proteins using complementary peptide tag-probe pairs are still limited, irrespective of the versatility of such pairs in biological research. Herein, we report the new CysHis tag-Ni(II) probe pair for the specific covalent labeling of proteins. A broad-range evaluation of the reactivity profiles of the probe and the CysHis peptide tag afforded a tag-probe pair with an optimized and high labeling selectivity and reactivity. In particular, the labeling specificity of this pair was notably improved compared to the previously reported one. This pair was successfully utilized for the fluorescence imaging of membrane proteins on the surfaces of living cells, demonstrating its potential utility in biological research.
- Zenmyo, Naoki,Tokumaru, Hiroki,Uchinomiya, Shohei,Fuchida, Hirokazu,Tabata, Shigekazu,Hamachi, Itaru,Shigemoto, Ryuichi,Ojida, Akio
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supporting information
p. 995 - 1000
(2019/07/18)
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- Radiolabeled Dibenzodiazepinone-Type Antagonists Give Evidence of Dualsteric Binding at the M2 Muscarinic Acetylcholine Receptor
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The dualsteric ligand approach, aiming at ligands with improved subtype selectivity, has been increasingly applied to muscarinic receptors (MRs). In this article, we present the synthesis and characterization of a M2R subtype-preferring radiola
- Pegoli, Andrea,She, Xueke,Wifling, David,Hübner, Harald,Bernhardt, Günther,Gmeiner, Peter,Keller, Max
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supporting information
p. 3314 - 3334
(2017/05/05)
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- POTENT AND SELECTIVE INHIBITORS OF NAV1.7
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Disclosed is a composition of matter comprising an isolated polypeptide, which is a peripherally-restricted NaV1.7 inhibitor. In some disclosed embodiments, the isolated polypeptide is an inhibitor of NaV1.7. Other embodiments are co
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Paragraph 1045-1046
(2016/02/18)
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- Peptide dendrimers with designer core for directed self-assembly
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A series of designer peptide dendrimers with urea and urea-triazole cores were synthesized. Urea cored dendrimers assembled into fibrillar morphology, while dendrimers with urea-triazole core assembled into vesicular morphology. The core-dependent self-as
- Verma, Ram P.,Shandilya, Ashutosh,Haridas
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supporting information
p. 8758 - 8765
(2015/10/20)
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- Crystal engineering of a microporous, catalytically active fcu topology MOF using a custom-designed metalloporphyrin linker
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A 12-connected fcu metal-organic framework (MOF), MMPF-3, has been prepared using a CoII metalloporphyrin. MMPF-3 is comprised of the same polyhedral supermolecular building blocks as the prototypal fcu-MOF, fcu-MOF-1, and its nanoscale cavities feature 18 catalytically active cobalt centers. The high density (ca. 5 cobalt sites/nm3) affords MMPF-3 superior performance in catalytic epoxidation of trans-stilbene compared to other MOFs. Copyright
- Meng, Le,Cheng, Qigan,Kim, Chungsik,Gao, Wen-Yang,Wojtas, Lukasz,Zaworotko, Michael J.,Zhang, X. Peter,Ma, Shengqian,Chen, Yu-Sheng
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supporting information
p. 10082 - 10085,4
(2020/09/09)
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- Non-aqueous pigmented inkjet inks
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A non-aqueous inkjet ink includes C.I. Pigment Yellow 150 and a polymeric dispersant according to Formula (I): wherein, T represents hydrogen or a polymerization terminating group; Z represents the residue of polyethyleneimine having a number-average mole
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Page/Page column 29-30
(2012/03/27)
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- AROMATIC COMPOUND, MODIFICATION CARRIER THAT USES SAME AND IS USED FOR SYNTHESIZING AN OLIGONUCLEOTIDE DERIVATIVE, OLIGONUCLEOTIDE DERIVATIVE, AND OLIGONUCLEOTIDE CONSTRUCT
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The present invention provides an oligonucleotide derivative that enables to easily synthesize an oligonucleotide derivative chemically modified at the 3'-end with two moieties each having a benzene or pyridine structure with a few steps, an aromatic compound serving as a precursor for preparing the modification carrier for synthesizing oligonucleotide derivative, and the oligonucleotide derivative and the oligonucleotide construct using the same, that is chemically modified at the 3'-end with two moieties each having a benzene or pyridine structure, and has good permeability through a cell membrane and excellent nuclease resistance. The modification carrier for synthesizing oligonucleotide derivative, comprising a unit and a carrier carrying the unit directly or via a linker, wherein the unit is represented by the formula (a): wherein, R1 to R6 each independently represent hydrogen or a substituent other than hydrogen; Z1 and Z2 each independently represent CH or nitrogen; and X represents oxygen or sulfur.
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Page/Page column 25-26
(2012/11/06)
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- Multi-tier dendrimers with an aromatic core
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We report various multi-tier designer dendritic molecules that incorporate an aromatic core and heterocyclic and peptide units. The 5-(azidomethyl)benzene- 1,3-dicarbonyl unit was chosen as the scaffold as this unit allows two identical units and a reacti
- Haridas,Sharma, Yogesti K.,Naik, Sarala
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body text
p. 1570 - 1577
(2009/07/11)
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- On the meaning of affinity: Cluster glycoside effects and concanavalin a
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The inhibition of protein - carbohydrate interaction provides a powerful therapeutic strategy for the treatment of myriad human diseases. To date, application of such approaches have been frustrated by the inherent low affinity of carbohydrate ligands for
- Dimick, Sarah M.,Powell, Steven C.,McMahon, Stephen A.,Moothoo, Davina N.,Naismith, James H.,Toone, Eric J.
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p. 10286 - 10296
(2007/10/03)
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- 76. Synthesis of Monodisperse Macromolecular Bicyclic and Dendritic Compounds from (R)-3-Hydroxybutanoic Acid and Benzene-1,3,5-tricarboxylic Acid and Analysis by Fragmenting MALDI-TOF Mass Spectroscopy
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As previously shown, oligo- and poly(β-hydroxyalkanoates) have a high tendency to form lamellar crystallites with ca. 50-A thickness which corresponds to chain lengths of 16 units (Fig. 1). To have monodisperse model compounds, we have now prepared bicyclic derivatives with three parallel (27-29) or two parallel and an antiparallel chain (68-70) consisting of up to 16 3-hydroxybutanoate (3-HB) units. We also prepared dendritic compounds (71-75, 82-85) containing oligo(3-HB) chains which cannot possibly he arranged as in the lamellae; the branching units were prepared from trimesic acid (= benzene-1,3,5-tricarboxylic acid). So far, none of the prepared samples formed crystals or contained crystalline domains which would have been suitable for single-crystal or powder-diffraction X-ray analysis. The terminally deprotected dendrimers (74, 75, and 85) are multi-anionic (up to 12 peripheral CO2H groups) and biodegradable. The macromolecular HB derivatives (molecular weight up to 10150 Da) have been fully characterized by IR, 1H- and 13C-NMR, [α]D, and elemental analysis. Especially important is the analysis by mass spectrometry with the MALDI-TOF technique (Fig. 2), proving that the products are monodisperse; application of a new variation of this MS method (post source decay = PSD or fragment analysis by structural time of night = FAST) allows for the observation of metastable fragment ions and, thus, is a tool for structural oligomer analysis (Fig. 3).
- Seebach, Dieter,Herrmann, Guido F.,Lengweiler, Urs D.,Amrein, Walter
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p. 989 - 1026
(2007/10/03)
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- Synthese und enzymatischer Abbau von Dendrimeren aus (R)-3-Hydroxybuttersaeure und Trimesinsaeure
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Keywords: Chiralitaet; Dendrimere; Enzyme
- Seebach, Dieter,Herrmann, Guido F.,Lengweiler, Urs D.,Bachmann, Beat M.,Amrein, Walter
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p. 2969 - 2972
(2007/10/03)
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