109877-38-5Relevant articles and documents
Access to C4-arylated benzoxazoles from 2-amidophenol through C-H activation
Panda, Niranjan,Pradhan, Priyanka,Sahoo, Kanchanbala
, p. 1820 - 1832 (2020/03/17)
A Pd-catalyzed aerobic approach to access C4-aryl benzoxazoles by tandem C-H ortho-arylation and acid-mediated annulation of 2-amidophenol has been presented. The directing potential of the -NHCOR group over the -OH group was exploited for selective arylation adjacent to the amide group. Deuterium labeling experiments suggest that palladation predominantly occurs adjacent to the -NHCOR group and is the key step during benzoxazole formation. One-pot hydrolysis of the resulting C4-arylated benzoxazole was also accomplished to access structurally challenging 3-aryl aminophenols for further applications.
Design, synthesis and structure-activity relationships of novel benzoxazolone derivatives as 18 kDa translocator protein (TSPO) ligands
Fukaya, Takayuki,Kodo, Toru,Ishiyama, Takeo,Kakuyama, Hiroyoshi,Nishikawa, Hiroyuki,Baba, Satoko,Masumoto, Shuji
, p. 5568 - 5582 (2012/10/29)
Selective 18 kDa translocator protein (TSPO) ligands are expected to be therapeutic agents with a wide spectrum of action on psychiatric disorders and fewer side effects. We designed novel benzoxazolone derivatives and examined the structure-activity rela