- Phosphorus pentasulfide mediated conversion of organic thiocyanates to thiols
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In this paper we report an efficient and mild procedure for the conversion of organic thiocyanates to thiols in the presence of phosphorus pentasulfide (P2S5) in refluxing toluene. The method avoids the use of expensive and hazardous transition metals and harsh reducing agents, as required by reported methods, and provides an attractive alternative to the existing methods for the conversion of organic thiocyanates to thiols.
- Maurya, Chandra Kant,Mazumder, Avik,Gupta, Pradeep Kumar
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supporting information
p. 1184 - 1188
(2017/07/03)
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- Two-step three-component process for one-pot synthesis of 8-alkylmercaptocaffeine derivatives
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A highly efficient, odourless and two-step three-component process for one-pot synthesis of some 8-alkylmercaptocaffeine derivatives has been described. The catalyst-free three-component reaction of alkyl bromides, thiourea, and 8-bromocaffeine gave 8-alkylmercaptocaffeine products in excellent to quantitative yields. In addition, the impact of parameters on sample reaction is discussed.
- Rad, M. N. Soltani,Maghsoudi
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p. 70335 - 70342
(2016/08/06)
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- Reductive removal of methoxyacetyl protective group using sodium borohydride
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Herein, we have developed a mild and selective reductive deprotection method for the MAc protected alcohols using sodium borohydride. The new deprotection conditions provide a complete orthogonality between O-MAc and other protecting groups such as tert-butyl ester, N-Boc, Fmoc, Cbz, O-TBDMS, N-benzyl, O-benzyl, O-acetyl, N-acetyl, N-MAc, etc. In addition to O-MAc deprotection, this method is also applicable for S-MAc deprotection.
- Gadekar, Pradip K.,Hoermann, Maryann,Corbo, Faith,Sharma, Rajiv,Sarveswari,Roychowdhury, Abhijit
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p. 503 - 506
(2014/01/06)
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- Hydrogen storage using heterocyclic compounds: The hydrogenation of 2-methylthiophene
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Alkyl substituted thiophenes are promising candidates for hydrogen carriers, as their dehydrogenation reactions are known to occur under mild conditions. Four types of catalysts, including supported noble metals, bimetallic noble metals, transition metal
- Zhao,Oyama,Naeemi
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scheme or table
p. 172 - 184
(2010/11/05)
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- Method of making 2-thiols
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A process for selectively making 2-thiols from alpha olefins is described. The process includes contacting a linear or branched alpha olefin having with H2S in the presence of a catalyst and recovering the 2-thiol from a product mixture. The catalyst includes a support and at least one metal selected from Group IIIA-VIIIA and the branched olefin is branched at the 3-position or higher with respect to the olefin double bond. Compositions wherein the 2-thiols are substantially free of 1 -thiol and 3-thiol isomers are also described.
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Page/Page column 5
(2008/06/13)
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- The Selective Deprotection of Thioesters Using Titanium(IV) Chloride/Zinc
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A new method for deprotection of thioesters using TiCl4/Zn at 0-25 deg C is described. The procedure chemoselectively cleaves the S-CO bond in thioesters in the presence of other carbonyl functional groups and other protecting groups to cleanly produce thiols.
- Jin, Chung Keun,Jeong, Hyung Jae,Kim, Min Kyu,Kim, Ju Young,Yoon, Yong-Jin,Lee, Sang-Gyeong
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p. 1956 - 1958
(2007/10/03)
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- METHOD FOR TREATING ANXIETY WITH MUSCARINIC CHOLINERGIC RECEPTOR AGONISTS
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The present invention relates a method for treating anxiety using azacyclic and azabicyclic pyrazine compounds.
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- Use of azacyclic or azabicyclic pyrazine compounds for treating anxiety
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The present invention relates a method for treating anxiety using azacyclic and azabicyclic pyrazine compounds.
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- ONE POT CONVERSION OF ALKYL HALIDES INTO THIOLS UNDER MILD CONDITIONS
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Alkyl halides are converted into the corresponding thiols in good yields at room temperature under neutral conditions by reaction with 1-(2-hydroxyethyl)-4,6-diphenylpyridine-2-thione.
- Molina, P.,Alajarin, M.,Vilaplana, M. J.,Katritzky, A. R.
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p. 469 - 472
(2007/10/02)
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- FORMATION OF SULPHUR COMPOUNDS IN HYDRODENITROGENATION OF QUINOLINE, 1,2,3,4-TETRAHYDROQUINOLINE, PYRIDINE, PIPERIDINE AND 1-PENT-4-ENYLAMINE ON A NICKEL-TUNGSTEN CATALYST IN THE PRESENCE OF HYDROGEN SULPHIDE
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Hydrodenitrogenation (HDN) of quinoline and 1,2,3,4-tetrahydroquinoline on a sulphided nickel-tungsten catalyst in the presence of hydrogen and of its mixture with hydrogen sulphide has been studied in an autoclave at 350 deg C.The results show that hydrogen sulphide exhibits rate-accelerating effect on HDN of the above compounds by formation of sulphur compounds.It was found that neutral portion of the reaction mixture contains octahydro-2H-1-benzothiopyran, octahydro-1H-2-benzothiopyran, octahydro-2-methylbenzo(b)thiophene and other sulphur compounds.The reaction scheme for HDN of quinoline that accounts for favourable effect of hydrogen sulphide is proposed.In the neutral portion of the reaction mixture from HDN of piperidine and 1-pent-4-enylamine in the presence of hydrogen sulphide further sulphur-containing compounds were identified.
- Cerny, Mirko,Trka, Antonin
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p. 1749 - 1758
(2007/10/02)
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- REDUCTION OF SULFONIC ACIDS WITH PHOSPHORUS PENTASULFIDE
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Arene, and alkanesulfonic acids are easily reduced to the corresponding polysulfides R-(S)n-R (n= 2.9 3.3) by treatment with phosphorus pentasulfide.In this reaction, the formation of both P-O-S and P-S-H linkages is considered to be involved in the key step of the reduction.
- Oae, Shigeru,Togo, Hideo
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p. 4701 - 4704
(2007/10/02)
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- FORMATION OF SULFUR COMPOUNDS IN THE HYDRODENITROGENATION OF PIPERIDINE, PYRIDINE, 1-PENTYLAMINE AND 1-PENT-4-ENYLAMINE ON A NICKEL-TUNGSTEN CATALYST IN THE PRESENCE OF HYDROGEN SULFIDE
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Hydrogenations of piperidine, pyridine, 1-pentylamine, and 1-pent-4-enylamine were carried out in an autoclave at 300 deg C on a sulfidized nickel-tungsten catalyst using either pure hydrogen or a mixture of hydrogen with hydrogen sulfide.Hydrogen sulfide was found to raise the degree of conversion of the starting substances and accelerate the hydrodenitrogenation by formation of sulfur compounds; 1-pentanethiol, di(1-pentyl)sulfide, 2-methylthiacyclopentane, thiacyclohexane and other sulfur compounds were detected in the reaction mixtures in the presence of hydrogensulfide.A reaction pathway is suggested of the hydrodenitrogenation of piperidine in the presence of hydrogen sulfide, accounting for the favourable effect of the latter on the hydrodenitrogenation of nitrogen compounds.
- Cerny, Mirko
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p. 928 - 935
(2007/10/02)
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- Antimicrobial composition and method containing N-(3,5-dihalophenyl)-imide compounds
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Novel N-(3,5-dihalophenyl)imide compounds, which exhibit a strong antimicrobial activity against microorganisms including phytopathogenic fungi, parasites of industrial products and pathogenic microorganisms, represented by the formula, STR1 wherein X and X' each represent halogens and A represents a substituted ethylene such as chloroethylene, C1 - C4 alkylthioethylene, C1 - C2 alkyl-ethylene or 1,2-di-C1 - C2 -alkyl-ethylene, a cyclopropylene such as 1,3-dimethylcyclopropylene, trimethylene, a cyclohexylene-1,2-, cyclohexenylene-1,2-, cyclohexadienylene-1,2- or o-phenylene. The N-(3,5-dihalophenyl)imide compounds can be obtained by any of methods which produce imide compounds or reaction of an N-(3,5-dihalophenyl)maleimide compound with a mercaptan, a hydrogen halide, phosphorus chloride or thionylchloride.
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