110-66-7 Usage
Chemical Properties
clear colorless liquid; meaty aroma. slightly soluble in water, easily soluble in alcohol and ether.
Uses
Different sources of media describe the Uses of 110-66-7 differently. You can refer to the following data:
1. 1-Pentanethiol is a raw material for organic synthesis. It is mainly used in the organic synthesis of sulfur compounds.
2. 1-Pentanethiol can be used as additives for hair coloring agents.
Preparation
1-Pentanethiol is synthesized from n-pentyl alcohol and hydrogen sulfide catalyzed by thorium dioxide.
Aroma threshold values
High strength odor; recommend smelling in a 0.10% solution or less.
General Description
1-Pentanethiol appears as a clear colorless to light-yellow liquid with an offensive odor. Flash point 65°F. Less dense than water and insoluble in water. Hence floats on water. Vapors are heavier than air. May be toxic by inhalation.
Air & Water Reactions
Highly flammable. Insoluble in water.
Reactivity Profile
1-Pentanethiol is incompatible with oxidizing agents, reducing agents, alkali metals, calcium hypochlorite, concentrated nitric acid .
Health Hazard
Inhalation may cause nausea because of offensive odor. Contact with eyes or skin causes slight irritation. Ingestion may cause vomiting.
Safety Profile
Moderately toxic by inhalation. A weak sensitizer and allergen. Local contact may cause contact dermatitis. A flammable liquid and dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidming materials. Hypergolic reaction with concentrated nitric acid. To fight fire, use foam, CO2, dry chemical. See also MERCAPTANS
Purification Methods
Dissolve the thiol in aqueous 20% NaOH, then extract with a small amount of diethyl ether. The aqueous solution is acidified slightly with 15% H2SO4, and the thiol is distilled out, dried with CaSO4 or CaCl2, and fractionally distilled under nitrogen. [Ellis & Reid J Am Chem Soc 54 1674 1932, Beilstein 1 IV 1453.]
Check Digit Verification of cas no
The CAS Registry Mumber 110-66-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 0 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 110-66:
(5*1)+(4*1)+(3*0)+(2*6)+(1*6)=27
27 % 10 = 7
So 110-66-7 is a valid CAS Registry Number.
InChI:InChI=1/C5H12S/c1-2-3-4-5-6/h6H,2-5H2,1H3
110-66-7Relevant articles and documents
Phosphorus pentasulfide mediated conversion of organic thiocyanates to thiols
Maurya, Chandra Kant,Mazumder, Avik,Gupta, Pradeep Kumar
supporting information, p. 1184 - 1188 (2017/07/03)
In this paper we report an efficient and mild procedure for the conversion of organic thiocyanates to thiols in the presence of phosphorus pentasulfide (P2S5) in refluxing toluene. The method avoids the use of expensive and hazardous transition metals and harsh reducing agents, as required by reported methods, and provides an attractive alternative to the existing methods for the conversion of organic thiocyanates to thiols.
Reductive removal of methoxyacetyl protective group using sodium borohydride
Gadekar, Pradip K.,Hoermann, Maryann,Corbo, Faith,Sharma, Rajiv,Sarveswari,Roychowdhury, Abhijit
, p. 503 - 506 (2014/01/06)
Herein, we have developed a mild and selective reductive deprotection method for the MAc protected alcohols using sodium borohydride. The new deprotection conditions provide a complete orthogonality between O-MAc and other protecting groups such as tert-butyl ester, N-Boc, Fmoc, Cbz, O-TBDMS, N-benzyl, O-benzyl, O-acetyl, N-acetyl, N-MAc, etc. In addition to O-MAc deprotection, this method is also applicable for S-MAc deprotection.
Method of making 2-thiols
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Page/Page column 5, (2008/06/13)
A process for selectively making 2-thiols from alpha olefins is described. The process includes contacting a linear or branched alpha olefin having with H2S in the presence of a catalyst and recovering the 2-thiol from a product mixture. The catalyst includes a support and at least one metal selected from Group IIIA-VIIIA and the branched olefin is branched at the 3-position or higher with respect to the olefin double bond. Compositions wherein the 2-thiols are substantially free of 1 -thiol and 3-thiol isomers are also described.