110482-96-7

Basic information

• Product Name: Ethyl 2,2-difluoropent-4-enoate
• Synonyms: Ethyl 2,2-difluoropent-4-enoate;2,2-Difluoro-4-pentenoic acid ethyl ester;Ethyl 2,2-difluoropentenoate;Ethyl 2,2-diflouro pentane-4-enoate;Ethyl 2,2-Difluoro-4-pentenoate
• CAS NO: 110482-96-7
• Molecular Formula: C₇H₁₀F₂O₂
• Molecular Weight: 164
• Mol File: 110482-96-7.mol

Chemical Properties

• Boiling Point: 128℃
• Flash Point: 31℃
• Appearance: /
• Density: 1.068
• Vapor Pressure: 11.1mmHg at 25°C
• Refractive Index: 1.388
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Ethyl 2,2-difluoropent-4-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 2,2-difluoropent-4-enoate(110482-96-7)
• EPA Substance Registry System: Ethyl 2,2-difluoropent-4-enoate(110482-96-7)

Safety Data

• Hazardous Substances Data: 110482-96-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
Ethyl 2,2-difluoropent-4-enoate is used as a building block in organic synthesis for the production of other chemical compounds. Its unique structure allows for the creation of a wide range of molecules with diverse properties and applications.
Used as a Solvent:
Due to its low boiling point and strong odor, Ethyl 2,2-difluoropent-4-enoate is used as a solvent in some applications. Its ability to dissolve certain substances makes it a valuable component in various chemical processes.
Used in Pharmaceutical Development:
Ethyl 2,2-difluoropent-4-enoate may have potential applications in the development of pharmaceuticals due to its unique chemical structure. Its properties can be harnessed to create new drugs with specific therapeutic effects.
Used in Agrochemical Development:
Similarly, Ethyl 2,2-difluoropent-4-enoate may also be utilized in the development of agrochemicals. Its unique structure can contribute to the creation of new compounds with potential applications in agriculture, such as pesticides or herbicides.

InChI:InChI=1/C7H10F2O2/c1-3-5-7(8,9)6(10)11-4-2/h3H,1,4-5H2,2H3

Upstream product

• 7648-30-8 ethyl 2,2-difluoro-2-iodoacetate 
• 12775-96-1 copper 
• 106-95-6 allyl bromide 
• 55039-89-9 2,2-difluoropent-4-enoic acid 
• 118373-18-5 trimethylsilyl 2,2-difluoro-4-pentenoate 
• 667-27-6 Ethyl bromodifluoroacetate 
• 24850-33-7 allyltributylstanane 
• 64-17-5 ethanol 
• 300-57-2 allylbenzene 
• 113991-43-8 2,2-Difluoro-pent-4-enoyl fluoride 

Downstream Products

• 1356335-46-0 (+)-N-allyl-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole 
• 1356335-37-9 (+)-(4R,5R)-2-(1,1-difluoro-3-butenyl)-4,5-dihydro-4,5-diphenylimidazole 
• 889866-61-9 5-allyl-6-(1,1-difluorobut-3-enyl)-3-(4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione 
• 889866-62-0 5-allyl-6-(1,1-difluorobut-3-enyl)-3-(4-fluorophenyl)pyrimidine-2,4(1H,3H)-dione 
• 889866-63-1 (R)-5-allyl-6-(1,1-difluorobut-3-enyl)-3-(1-phenylethyl)pyrimidine-2,4(1H,3H)-dione 
• 889866-79-9 1-allyl-6-(1,1-difluorobut-3-enyl)-3-(4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione 
• 889866-80-2 1-allyl-6-(1,1-difluorobut-3-enyl)-3-(4-fluorophenyl)pyrimidine-2,4(1H,3H)-dione 
• 889866-81-3 (R)-1-allyl-6-(1,1-difluorobut-3-enyl)-3-(1-phenylethyl)pyrimidine-2,4(1H,3H)-dione 
• 889866-56-2 5-allyl-6-(1,1-difluorobut-3-enyl)-3-phenylpyrimidine-2,4(1H,3H)-dione 
• 889866-76-6 1-allyl-6-(1,1-difluorobut-3-enyl)-3-phenylpyrimidine-2,4(1H,3H)-dione 
• 889866-55-1 6-(1,1-difluorobut-3-enyl)-3-phenyl-5-vinylpyrimidine-2,4(1H,3H)-dione 
• 889866-57-3 6-(1,1-difluorobut-3-enyl)-3-(4-methoxyphenyl)pyrimidine-2,4(1H,3H)-dione 
• 889866-59-5 (R)-6-(1,1-difluorobut-3-enyl)-3-(1-phenylethyl)pyrimidine-2,4(1H,3H)-dione 
• 889866-58-4 6-(1,1-difluorobut-3-enyl)-3-(4-fluorophenyl)pyrimidine-2,4(1H,3H)-dione 

Relevant articles and documents

Radical reaction using an organocopper reagent derived from ethyl bromodifluoroacetate

In our previous work, reaction of ethyl bromodifluoroacetate (1) in the presence of Cu powder with olefins activated by an electron-withdrawing group gave the Michael-type adducts through an anionic intermediate. The same reaction with non-activated olefi

Reactions of ethyl bromodifluoroacetate in the presence of copper powder

We have examined the reaction of ethyl bromodifluoroacetate (1) in the presence of copper powder as a procedure for the synthesis of compounds containing a CF2 group. The complex formed in the above reaction reacted with vinyl or aryl iodides t

Preparative Flow Techniques; 1. Low-Temperature Organometallic Reactions: Synthesis of Ethyl 2,2-Difluoro-4-pentenoate

A convenient preparation of the synthetically useful ethyl 2,2-difluoro-4-pentenoate using the low-temperature flow technique is described.The method is suitable for small-scale as well as for large-scale application.

A new strategy for the synthesis of fluorinated 3,4-dihydropyrimidinones

A new family of 3,4-dihydropyrimidinones (DHPMs) bearing fluorinated substituents at C6 have been prepared from gem-difluorinated nitriles, alkyl 3-butenoates and iso(thio)cyanates. This novel Biginelli-type process relies on the γ-addition of the ester-derived enolate to fluorinated nitriles. A tandem nucleophilic addition aza-Michael reaction sequence completes the synthetic process.

Synthesis and biological evaluation of new bicyclic fluorinated uracils through ring-closing metathesis

Two families of bicyclic fluorinated uracils have been prepared starting from a gem-difluorinated unsaturated nitrile, by means of a ring-closing metathesis reaction to form the new ring, which is fused at the C-5/C-6 or N-1/C-6 positions of the uracil mo

FLUORINATED ALKENYLTRIAZINES AND THEIR USE AS CROSSLINKING AGENTS

Disclosed herein are novel fluorinated vinyl and allyl substituted fluoroalkyl containing triazines and a process in which they are used as curing agents for the crosslinking of suitable fluoroelastomers. These polymers are useful in elastomeric seals and for other uses in which high temperature and/or chemical resistance is needed.

Process for the preparation of 2,2-difluoropent-4-enoic acids and acid derivatives

The reaction of allyl bromo- or chloro-difluoroacetates with monochlorisilanes in the presence of zinc with heating gives silyl esters of α,α-difluoro-γ,δ-pentenoic acids. The free acids, from which acid derivatives can be prepared by conventional methods, are obtained by hydrolysis. The pentenoic acids and pentenoic acid derivatives are suitable for the preparation of polymers and copolymers, from which metal-organic polymers and copolymers having catalytic properties are obtainable.

Continuous large-scale production of ethyl 2,2-difluoro-4-pentenoate and 2-fluorinated methyl aminoacetonitriles by use of a flow reactor

The large scale preparation of ethyl 2,2-difluoro-4- pentenoate and 2-fluorinated methyl aminoacetonitriles by reaction of 2-H-perfluoroethyl allyl ether and n-butyl lithium and fluoromethylacetonitrile and a Grignard reagent, respectively, is largly unsuccessful because of side reactions which convert intermediate products and reactants to undesired products. Applicants have overcome these problems by performing the reactions with cooling in a continuous manner in a flow reactor with short residence time.

FLUORINE-CONTAINING ORGANOZINC REAGENTS. V. THE REFORMATSKII-CLAISEN REACTION OF CHLORODIFLUOROACETIC ACID DERIVATIVES

Silicon induced Reformatskii-Claisen reaction of allyl chlorodifluoroacetate (1) affords 2,2-difluoro-4-pentenoic acid (2) in good yields.Starting from inexpensive chlorodifluoroacetic acid, a variety of useful fluorine-containing synthetic building block