7648-30-8

Basic information

• Product Name: Ethyl iododifluoroacetate
• Synonyms: ETHYL IODODIFLUOROACETATE;DIFLUOROIODOACETIC ACID ETHYL ESTER;ethyldifluoroiodoacetate;Ethyl iododifluoroacetate 97%;Ethyliododifluoroacetate97%;Ethyl difluoro(iodo)acetate 97%;2,2-Difluoro-1-ethoxy-2-iodoethan-1-one;Ethyl 2,2-difluoro-2-iodoacetate
• CAS NO: 7648-30-8
• Molecular Formula: C₄H₅F₂IO₂
• Molecular Weight: 249.98
• Mol File: 7648-30-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 65 °C
• Flash Point: 45.4 °C
• Appearance: /
• Density: 1.7
• Vapor Pressure: 3.66mmHg at 25°C
• Refractive Index: 1.469
• CAS DataBase Reference: Ethyl iododifluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl iododifluoroacetate(7648-30-8)
• EPA Substance Registry System: Ethyl iododifluoroacetate(7648-30-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: IRRITANT
• Hazardous Substances Data: 7648-30-8(Hazardous Substances Data)

Usage

General Description

Ethyl iododifluoroacetate is a chemical compound with the formula C4H6F2IO2. It is a colorless liquid with a pungent odor, and is commonly used as a reagent in organic synthesis. Ethyl iododifluoroacetate is highly reactive and can undergo nucleophilic substitution reactions with a variety of nucleophiles to form new carbon-carbon and carbon-heteroatom bonds. It is used in the pharmaceutical industry to synthesize complex organic molecules, and in the production of specialty chemicals. However, ethyl iododifluoroacetate is also highly toxic and should be handled with caution, as it can cause serious health effects if proper safety precautions are not followed.

InChI:InChI=1/C4H5F2IO2/c1-2-9-3(8)4(5,6)7/h2H2,1H3

Upstream product

• 674-02-2 1-chloro-1,3,3-trifluoro-3-iodo-propene 
• 64-17-5 ethanol 
• 192569-10-1 2-iodo-1,1,2,2-tetrafluoroethyl chlorosulfate 
• 77570-00-4 2-iodo-tetrafluoroethyl fluorosulfate 
• 101068-09-1 ethyl fluorosulfonoxydifluoroacetate 
• 667-27-6 Ethyl bromodifluoroacetate 

Downstream Products

• 74106-81-3 ethyl 2,2-difluorohexanoate 
• 454-31-9 ethyl difluoroacetate 
• 127224-10-6 Ethyl 2,2-Difluoro-4-iodononanoate 
• 134682-32-9 trans-ethyl-α,α-difluoro-(2-iodocyclohexanyl)acetate 
• 134682-30-7 cis-ethyl-α,α-difluoro-(2-iodocyclohexanyl)acetate 
• 101068-11-5 ethyl 2,2-difluoro-2-(phenylthio)acetate 
• 1372764-79-8 (3S)-ethyl 2,2-difluoro-3-hydroxy-3-(2-methoxyphenyl)butanoate 
• 1372764-84-5 (3S)-ethyl 2,2-difluoro-3-hydroxy-5-methyl-3-phenylhexanoate 
• 1372764-81-2 (3S)-ethyl 2,2-difluoro-3-hydroxy-3-(4-chlorophenyl)butanoate 
• 1372764-83-4 (3S)-ethyl 2,2-difluoro-3-hydroxy-3-phenylhexanoate 
• 1372764-78-7 (3S)-ethyl 2,2-difluoro-3-hydroxy-3-phenylbutanoate 
• 1372764-82-3 (3S)-ethyl 2,2-difluoro-3-hydroxy-3-phenylpentanoate 

Relevant articles and documents

Copper-Catalyzed Three-Component Reactions of 2-Iodo-2,2-difluoroacetophenones, Alkynes, and Trimethylsilyl Cyanide

A Cu(I)-catalyzed three-component reaction of 2-iodo-2,2-difluoroacetophenones, alkynes, and TMSCN is described. The reaction provided a facile method for the synthesis of difluoroacyl-substituted nitriles, which might be served as potentially useful fluo

New and Efficient Syntheses of α-Iodo-α,α-Difluoro- and β-Iodo-α,α,β,β-Tetrafluorocarboxylic Acid Derivatives as Useful Building Blocks for Making Functional Fluoro Compounds

Perfluoroolefins reacted with I-Cl and ClSO3H under mild conditions to give RFCFICF2OSO2Cl, which could be readily converted into various α-iodo-perfluorocarboxylic acid derivatives or telomerized with tetrafluo

Synthesis of Aryl &α,&α-Difluoroalkyl Ketones as Potent Inhibitors of Cholesterol Esterase

Aryl α,α-difluoroalkyl ketones were synthesized from the reaction of ethyl α,α-difluoroacylate with aryl lithium at -78 deg C or from the coupling of aryl iododifluoromethyl ketone with 1-alkene in the presence of teterakis(triphenylphisphine)palladium(0).These compounds were potent inhibitors of pancreatic cholesterol esterase with Ki values in the range 15 μM-20 nM.