The present invention relates to a process for the preparation of floxuridine, said process comprising reacting a compound of Formula la with a compound of Formula lla in the presence of an acid Al to provide a compound of Formula Ilia in substantially diastereomerically pure form. Floxuridine may be useful as an anti-cancer drug. Floxuridine may also be useful in the preparation of other anti-cancer drugs, e.g. NUC-3373.
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Page/Page column 32-33
(2019/04/11)
Stereoselective synthesis of anomers of 5-substituted 2'-deoxyuridines
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Aoyama
p. 2073 - 2077
(2007/10/02)
Stereoselective synthesis of the anomeric 5-mercapto-2'deoxyuridines and of some other alpha-and beta-deoxyribonucleosides.
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Bardos,Kotick,Szantay
p. 1759 - 1764
(2007/10/07)
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