- PROCESS FOR THE PREPARATION OF AN ENDOTHELIN RECEPTOR ANTAGONIST
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The present invention relates to a novel process for the preparation of a compound of formula (I) wherein R is a methyl or methoxy group; to certain novel intermediates prepared in such a process and their use.
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Page/Page column 21-22
(2013/05/09)
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- Synthesis of (+)-ambrisentan via chiral ketone-catalyzed asymmetric epoxidation
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The synthesis of optically pure (+)-ambrisentan has been achieved from 3,3-diphenylacrylate in four steps with 53% overall yield and >99% ee at the >100 g scale without column purification. The chiral epoxide intermediate was prepared via asymmetric epoxi
- Peng, Xianyou,Li, Peijun,Shi, Yian
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p. 701 - 703
(2012/03/26)
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- Improved Process For The Preparation Of Endothelin Receptor Antagonists
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The present invention relates to improved processes for the preparation of Endothelin receptor antagonists, their salts and intermediates.
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Page/Page column 9
(2011/11/06)
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- IMPROVED PROCESS FOR THE PREPARATION OF ENDOTHELIN RECEPTOR ANTAGONISTS
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The present invention relates to improved processes for the preparation of Endothelin receptor antagonists, their salts and intermediates.
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Page/Page column 21
(2010/08/05)
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- METABOLITES AND DERIVATIVES OF AMBRISENTAN
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The invention relates to derivatives and metabolites of ambrisentan, including compounds of general Formula (I) or salts, hydrates, solvates, racemates, or optical isomers thereof, wherein R1 is -H or -OCH3; R2is-H, lower alkyl (e.g. C1-C4 alkyl) or glyco
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Page/Page column 24-25
(2009/03/07)
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