1106685-61-3

Usage

Uses

Used in Pharmaceutical Industry:
(S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate is used as a key ingredient in the production of various drugs, particularly in the development of medications targeting specific biological pathways. Its unique chemical structure and properties make it a valuable component in the synthesis of pharmaceutical compounds.
Used in Biochemical Research and Development:
(S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate is also used in biochemical research and development due to its potential biological activity and medicinal potential. (S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate can be utilized in the study of various biological processes and the development of new therapeutic agents.

Upstream product

• 1431363-04-0 methyl 3-methoxy-2-oxo-3,3-diphenylpropionate 
• 35144-22-0 4,6-dimethyl-2-methylsulfonylpyrimidine 
• 177036-78-1 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester 
• 177036-94-1 ambrisentan 
• 74-88-4 methyl iodide 
• 876148-89-9 ethyl 2-hydroxy-3-methoxy-3,3-diphenylpropionate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 178306-51-9 (S)-2-hydroxy-3-methoxy-3,3-diphenyl propionic acid 
• 178306-47-3 2-hydroxy-3-methoxy-3,3-diphenylpropionicacid methyl ester 
• 178306-52-0 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid 
• 119-61-9 benzophenone 

Downstream Products

• 1106685-62-4 (S)-methyl 2-(4-formyl-6-methylpyrimidin-2-yloxy)-3-rnethoxy-3,3-diphenylpropanoate 
• 177036-94-1 ambrisentan 
• 1231755-51-3 (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid dicyclohexylamine salt 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF AN ENDOTHELIN RECEPTOR ANTAGONIST

The present invention relates to a novel process for the preparation of a compound of formula (I) wherein R is a methyl or methoxy group; to certain novel intermediates prepared in such a process and their use.

Synthesis of (+)-ambrisentan via chiral ketone-catalyzed asymmetric epoxidation

The synthesis of optically pure (+)-ambrisentan has been achieved from 3,3-diphenylacrylate in four steps with 53% overall yield and >99% ee at the >100 g scale without column purification. The chiral epoxide intermediate was prepared via asymmetric epoxi

Improved Process For The Preparation Of Endothelin Receptor Antagonists

The present invention relates to improved processes for the preparation of Endothelin receptor antagonists, their salts and intermediates.

IMPROVED PROCESS FOR THE PREPARATION OF ENDOTHELIN RECEPTOR ANTAGONISTS

The present invention relates to improved processes for the preparation of Endothelin receptor antagonists, their salts and intermediates.

METABOLITES AND DERIVATIVES OF AMBRISENTAN

The invention relates to derivatives and metabolites of ambrisentan, including compounds of general Formula (I) or salts, hydrates, solvates, racemates, or optical isomers thereof, wherein R1 is -H or -OCH3; R2is-H, lower alkyl (e.g. C1-C4 alkyl) or glyco