1106685-61-3

Basic information

• Product Name: (S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate
• Synonyms: (S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate;Methyl (2S)-2-[(4,6-diMethyl-2-pyriMidinyl)oxy]-3-Methoxy-3,3-diphenylpropanoate;(alphaS)-alpha-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-beta-methoxy-beta-phenylbenzenepropanoic acid methyl ester;Ambrisentan PI-6
• CAS NO: 1106685-61-3
• Molecular Formula: C₂₃H₂₄N₂O₄
• Molecular Weight: 392.44766
• EINECS: 1533716-785-6
• Mol File: 1106685-61-3.mol
• Article Data: 5

Chemical Properties

• Appearance: White-like to white solid
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate(1106685-61-3)
• EPA Substance Registry System: (S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate(1106685-61-3)

Safety Data

• Hazardous Substances Data: 1106685-61-3(Hazardous Substances Data)

Usage

General Description

(S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate is a chemical compound with the molecular formula C24H27N3O4. It is a propanoate derivative and belongs to the class of organic compounds known as phenylpropanoic acids. (S)-Methyl 2-(4,6-diMethylpyriMidin-2-yloxy)-3-Methoxy-3,3-diphenylpropanoate is used in the pharmaceutical industry as a key ingredient in the production of various drugs, particularly in the development of medications targeting specific biological pathways. Its unique chemical structure and properties make it a valuable component in the synthesis of pharmaceutical compounds. Additionally, it is also used in biochemical research and development due to its potential biological activity and medicinal potential.

Upstream product

• 35144-22-0 4,6-dimethyl-2-methylsulfonylpyrimidine 
• 177036-78-1 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid methyl ester 
• 177036-94-1 ambrisentan 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 876148-89-9 ethyl 2-hydroxy-3-methoxy-3,3-diphenylpropionate 
• 1431363-04-0 methyl 3-methoxy-2-oxo-3,3-diphenylpropionate 
• 178306-51-9 (S)-2-hydroxy-3-methoxy-3,3-diphenyl propionic acid 
• 178306-47-3 2-hydroxy-3-methoxy-3,3-diphenylpropionicacid methyl ester 
• 178306-52-0 (S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid 
• 119-61-9 benzophenone 
• 74-88-4 methyl iodide 

Downstream Products

• 1106685-62-4 (S)-methyl 2-(4-formyl-6-methylpyrimidin-2-yloxy)-3-rnethoxy-3,3-diphenylpropanoate 
• 177036-94-1 ambrisentan 
• 1231755-51-3 (+)-(2S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid dicyclohexylamine salt 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF AN ENDOTHELIN RECEPTOR ANTAGONIST

The present invention relates to a novel process for the preparation of a compound of formula (I) wherein R is a methyl or methoxy group; to certain novel intermediates prepared in such a process and their use.

Improved Process For The Preparation Of Endothelin Receptor Antagonists

The present invention relates to improved processes for the preparation of Endothelin receptor antagonists, their salts and intermediates.

METABOLITES AND DERIVATIVES OF AMBRISENTAN

The invention relates to derivatives and metabolites of ambrisentan, including compounds of general Formula (I) or salts, hydrates, solvates, racemates, or optical isomers thereof, wherein R1 is -H or -OCH3; R2is-H, lower alkyl (e.g. C1-C4 alkyl) or glyco