110718-94-0

Basic information

• Product Name: N(7)-phenylguanine
• Synonyms: N(7)-phenylguanine
• CAS NO: 110718-94-0
• Molecular Formula: C₁₁H₉N₅O
• Molecular Weight: 227.22206
• Mol File: 110718-94-0.mol

Chemical Properties

• Boiling Point: 515.2°Cat760mmHg
• Flash Point: 265.4°C
• Appearance: /
• Density: 1.58g/cm³
• Vapor Pressure: 1E-10mmHg at 25°C
• Refractive Index: 1.804
• CAS DataBase Reference: N(7)-phenylguanine(CAS DataBase Reference)
• NIST Chemistry Reference: N(7)-phenylguanine(110718-94-0)
• EPA Substance Registry System: N(7)-phenylguanine(110718-94-0)

Safety Data

• Hazardous Substances Data: 110718-94-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H9N5O/c12-11-14-9-8(10(17)15-11)16(6-13-9)7-4-2-1-3-5-7/h1-6H,(H3,12,14,15,17)

Upstream product

• 420-04-2 CYANAMID 
• 62011-88-5 4-Amino-1-phenyl-5-imidazolcarbonsaeure-ethylester 
• 1159192-14-9 7-methyl-1-phenylpyrimido[1,2-a]purin-10(1H)-one 
• 1159192-32-1 N₂-[(dimethylamino)methylene]-7-phenylguanine 
• 108-86-1 bromobenzene 
• 73-40-5 2-amino-1,9-dihydro-6H-purin-6-one 
• 591-50-4 iodobenzene 

Relevant articles and documents

Direct N9-arylation of purines with aryl halides

An efficient method for N-arylation of purines is reported. The N-arylation is catalysed by Cu(i) and 4,7-bis(2-hydroxyethylamino)-1,10-phenanthroline (BHPhen) in aqueous DMF or ethanol. The reaction generally proceeds with high selectivity for the N

New Approach to the Synthesis of N7-Arylguanines and N 7-Aryladenlnes

The copper-mediated arylation of 7-methylpyrimido[1, 2-α]- purin-10(3H)-one (1) in dichloromethane or of N7- (climethylaminojmethyleneguanine (2) in methanol in the presence of TMEDA as a base/ligand led to the preferential formation of l-aryl-

Aryl-Substituted Purines, I. - Synthesis of 7-Phenylguanine and of 2-Substituted 7-Arylhypoxanthines

The synthesis of 7-phenylguanine (2) by cyclisation reaction of ethyl 4-amino-1-phenyl-5-imidazolecarboxylate (1a) with cyanamide is described.This reaction is the first and hitherto only synthetic approach to a hypothetical base adduct the significance of which is discussed in relation to the carcinogenesis of benzene.Moreover, the 2-substituted 7-arylhypoxanthines 4a-e have been prepared by reaction of ethyl 1-aryl-4-amino-5-imidazolecarboxylates 1a-c with thioamides 3a-c.Formic acid proved to be the best catalyst.By this new procedure starting compounds for the d evelopment of a radioimmuno assay for the trace analysis of 2 can be prepared in good yields.