N(7)-phenylguanine

Base Information

• Chemical Name: N(7)-phenylguanine
• CAS No.: 110718-94-0
• Molecular Formula: C11H9 N5 O
• Molecular Weight: 227.22
• Hs Code.: 2933990090
• Mol file: 110718-94-0.mol

Synonyms:N(7)-phenylguanine

Chemical Property of N(7)-phenylguanine

Chemical Property:

• Vapor Pressure: 1E-10mmHg at 25°C
• Boiling Point: 515.2°Cat760mmHg
• Flash Point: 265.4°C
• PSA: 90.58000
• Density: 1.58g/cm³
• LogP: 1.03340

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N(7)-phenylguanine

There total 5 articles about N(7)-phenylguanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N2-[(dimethylamino)methylene]-7-phenylguanine (1159192-32-1) → 7-phenylguanine (110718-94-0)

Guidance literature:

With hydrogenchloride; In water; Reflux;

DOI:10.1002/ejoc.200801002

Reference yield: 68.0%

7-methyl-1-phenylpyrimido[1,2-a]purin-10(1H)-one (1159192-14-9) → 7-phenylguanine (110718-94-0)

Guidance literature:

With sodium hydroxide; water; Reflux;

DOI:10.1002/ejoc.200801002

Reference yield: 60.0%

iodobenzene (591-50-4) + 2-amino-1,9-dihydro-6H-purin-6-one (73-40-5) → 2-amino-9-phenyl-1H-purin-6(9H)-one (14443-33-5) + 7-phenylguanine (110718-94-0)

Guidance literature:

With N⁴,N⁷-bis(2-hydroxyethyl)-1,10-phenanthroline-4,7-diamine; potassium hydroxide; copper(I) bromide; In water; N,N-dimethyl-formamide; at 120 ℃; for 21h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1039/c3cc48642g

upstream raw materials:

CYANAMID

4-Amino-1-phenyl-5-imidazolcarbonsaeure-ethylester

7-methyl-1-phenylpyrimido[1,2-a]purin-10(1H)-one

N₂-[(dimethylamino)methylene]-7-phenylguanine

Refernces

• 1、 Keder, Roman,Dvorakova, Hana,Dvorak, Dalimil. "New Approach to the Synthesis of N7-Arylguanines and N 7-Aryladenlnes". experimental part. p. 1522 - 1531. Retrieved 2009/07/19.