111005-65-3Relevant articles and documents
Reinvestigation of the synthesis of (2R,3R) 2,3-(cyclohexylidenedioxy)-4-cyclopentenone as possible building block for the synthesis of carbocyclic nucleosides
Marien,Esmans,Lemiere,Dommisse
, p. 205 - 224 (1997)
An in depth study of the four-steps synthesis of (2R,3R) 2,3-(cyclohexylidenedioxy)-4-cyclopentenone (5) from D-ribonolactone (1) is described. From these experiments we must conclude that the overall yield reported in the literature (65%) is overestimated. All compounds have been throughly investigated by 1H- and 13C-NMR spectroscopy.
Short and efficient synthesis of enantiomerically pure building blocks for the preparation of carbocyclic nucleosides and prostaglandins via diastereoselective dihydroxylation of 5-menthyloxy-2[5H]-furanone
Sundermann, Bernd,Scharf, Hans-Dieter
, p. 1995 - 1998 (1996)
A short and efficient synthesis of both enantiomerically pure 2,3-(Cyclohexylidenedioxy)-4-cyclopentenones 4 and ent-4 from the readily available 5-menthyloxy-2[5H]-furanones 1 and ent-1 is presented. The key step is the substrate controlled diastereosele
NON-RIBOSE CONTAINING INHIBITORS OF HISTONE METHYLTRANSFERASE DOT1L FOR CANCER TREATMENT
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Paragraph 0060; 0061; 00106, (2015/02/19)
A compound of Formula I, a pharmaceutically acceptable salt thereof, a prodrug thereof, or combinations thereof: wherein R1 is H, methyl, or benzyl: R2 is 2-cyanoethyl, 2-methoxycarbonylethyl, or 2-iodoethyl; X is N or S; wherein if
Synthesis, activity and metabolic stability of non-ribose containing inhibitors of histone methyltransferase DOT1L
Deng, Lisheng,Zhang, Li,Yao, Yuan,Wang, Cong,Redell, Michele S.,Dong, Shuo,Song, Yongcheng
, p. 822 - 826 (2013/08/26)
Histone methyltransferase DOT1L is a drug target for MLL leukemia. We report an efficient synthesis of a cyclopentane-containing compound that potently and selectively inhibits DOT1L (Ki = 1.1 nM) as well as H3K79 methylation (IC50 ～
