111153-83-4

Basic information

• Product Name: 4-(3-METHYLPHENYL)PIPERIDINE
• Synonyms: 4-(3-METHYLPHENYL)PIPERIDINE;4-(M-TOLYL)PIPERIDINE;Piperidine, 4-(3-methylphenyl)-;4-(3-Methylphenyl)piperidine HCl
• CAS NO: 111153-83-4
• Molecular Formula: C₁₂H₁₇N
• Molecular Weight: 175.27
• Mol File: 111153-83-4.mol

Chemical Properties

• Boiling Point: 279℃
• Flash Point: 125℃
• Appearance: /
• Density: 0.958
• Vapor Pressure: 0.00418mmHg at 25°C
• Refractive Index: 1.52
• Storage Temp.: 2-8°C(protect from light)
• PKA: 10.28±0.10(Predicted)
• CAS DataBase Reference: 4-(3-METHYLPHENYL)PIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-METHYLPHENYL)PIPERIDINE(111153-83-4)
• EPA Substance Registry System: 4-(3-METHYLPHENYL)PIPERIDINE(111153-83-4)

Safety Data

• Statements: 52
• Hazardous Substances Data: 111153-83-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(3-METHYLPHENYL)PIPERIDINE is used as a key intermediate in the synthesis of various pharmaceutical compounds for its diverse biological activities. Its unique structure allows for the development of drugs targeting specific receptors or enzymes, potentially leading to the creation of novel therapeutic agents.
Used in Drug Discovery and Development:
4-(3-METHYLPHENYL)PIPERIDINE serves as a valuable building block in medicinal chemistry, enabling the design and optimization of drug candidates with improved pharmacological properties. Its presence in a molecule can modulate the activity, selectivity, and pharmacokinetics of the resulting drug, making it an essential component in the drug discovery process.
Used in Research and Development of CNS Active Compounds:
4-(3-METHYLPHENYL)PIPERIDINE is utilized in the research and development of compounds with central nervous system (CNS) activity. Its structural features allow for the modulation of neurotransmitter systems, potentially leading to the development of treatments for neurological and psychiatric disorders.
Used in Synthesis of Opioid Modulators:
4-(3-METHYLPHENYL)PIPERIDINE is employed in the synthesis of opioid modulators, which can either enhance or diminish the effects of opioids. These compounds have potential applications in the management of pain, addiction, and overdose, offering new therapeutic options for patients.
Used in Development of Antidepressant Agents:
4-(3-METHYLPHENYL)PIPERIDINE is used in the development of antidepressant agents, as its structural features can interact with specific receptors in the brain, modulating neurotransmitter levels and alleviating depressive symptoms.

InChI:InChI=1/C12H17N/c1-10-3-2-4-12(9-10)11-5-7-13-8-6-11/h2-4,9,11,13H,5-8H2,1H3

Upstream product

• 694-05-3 1,2,3,6-tetrahydropyridine 
• 108-88-3 toluene 

Downstream Products

• 107336-14-1 2-[2-(4-m-Tolyl-piperidin-1-yl)-ethoxy]-benzaldehyde 
• 107335-65-9 2-{2-[2-(4-m-Tolyl-piperidin-1-yl)-ethoxy]-phenyl}-thiazolidine-3-carboxylic acid methylamide 
• 107335-88-6 2-{2-[2-(4-m-Tolyl-piperidin-1-yl)-ethoxy]-phenyl}-thiazolidine-3-carbothioic acid methylamide 
• 1010073-16-1 C₂₅H₃₆N₂O₃ 
• 1430328-44-1 C₁₅H₂₃N 

Relevant articles and documents

20-HETE FORMATION INHIBITORS

This disclosure provides novel heterocyclic compounds and methods for inhibiting the enzyme CYP4. Further disclosed methods include: a method of inhibiting the biosynthesis of 20-hydroxyeicosatetraenoic acid (20-HETE) in a subject in need thereof and a method of producing neuroprotection and decreased brain damage by preventing cerebral microvascular blood flow impairment and anti-oxidant mechanisms in a subject experiencing or having experienced an ischemic event.

Superacid-catalyzed preparation of aryl-substituted piperidines via dicationic electrophiles

The electrophilic chemistry of 1,2,3,6-tetrahydropyridines has been studied in the Bronsted superacid, CF3SO3H (triflic acid). The 1,2,3,6-tetrahydropyridines react with arenes to give aryl-substituted piperidines. It is proposed tha