111222-19-6

Basic information

• Product Name: 2-Azetidinecarboxylic acid, 4-oxo-, methyl ester (9CI)
• Synonyms: 2-Azetidinecarboxylic acid, 4-oxo-, methyl ester (9CI);Methyl 4-oxoazetidine-2-carboxylate
• CAS NO: 111222-19-6
• Molecular Formula: C5H7NO3
• Molecular Weight: 129.11398
• Product Categories: ACIDHALIDE
• Mol File: 111222-19-6.mol

Chemical Properties

• Boiling Point: 296.5±33.0 °C(Predicted)
• Appearance: /
• Density: 1.276±0.06 g/cm3(Predicted)
• PKA: 13.79±0.40(Predicted)
• CAS DataBase Reference: 2-Azetidinecarboxylic acid, 4-oxo-, methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Azetidinecarboxylic acid, 4-oxo-, methyl ester (9CI)(111222-19-6)
• EPA Substance Registry System: 2-Azetidinecarboxylic acid, 4-oxo-, methyl ester (9CI)(111222-19-6)

Safety Data

• Hazardous Substances Data: 111222-19-6(Hazardous Substances Data)

Usage

Chemical compound

2-Azetidinecarboxylic acid, 4-oxo-, methyl ester (9CI)

Derivative of

2-azetidinecarboxylic acid

Usage

Building block in organic synthesis and pharmaceutical research

Potential applications

Drug development, creation of new molecules with therapeutic properties, development of materials and polymers

Caution

Handle and use with caution due to potential hazards and toxicity

Upstream product

• 107020-12-2 methyl N-tert-butyloxycarbonyl-L-azetidine-2-carboxylate 
• 107020-13-3 methyl N-tert-butyloxycarbonyl-L-azetidinon-2-carboxylate 
• 75-07-0 acetaldehyde 
• 100188-48-5 (3S,4R)-3-(trimethylsilyl)-2-oxoazetidine-4-carboxylic acid methyl ester 
• 67-56-1 methanol 
• 72776-05-7 (S)-benzyl 4-oxoazetidine-2-carboxylate 
• 186581-53-3 diazomethane 
• 16404-94-7 (S)-4-oxo-azetidine-2-carboxylic acid 

Downstream Products

• 83865-35-4 4-[N-(2-propenyl)-(4-toluenesulfonamido)]azetidin-2-one 

Relevant articles and documents

Dirhodium(II) tetrakis[methyl 2-oxaazetidine-4-carboxylate]: A chiral dirhodium(II) carboxamidate of exceptional reactivity and selectivity

A new chiral azetidinone-carboxylate ligand for dirhodium(II) catalysts enhances reactivity toward diazo decomposition and selectivity toward cyclopropanation enabling diazomalonates, vinyldiazoacetates, and aryldiazoacetates to be effectively used with a dirhodium(II) carboxamidate catalyst.

Synthesis of optically active 4-alkoxycarbonyl-β-lactams from L-aspartic acid

Cyclization of L-aspartic acid to (S)-4-benzyloxycarbonyl-2- azetidinone followed by transesterification of this compound in the presence of titanium (IV) tetrabutoxide proved to be an exceedingly efficient method of general application for the preparatio

A NEW SYNTHESIS OF OPTICALLY ACTIVE 2-METHOXYCARBONYL-4-AZETIDINONE FROM L-AZETIDINE-2-CARBOXYLIC ACID: UTILITY OF RUTHENIUM TETROXIDE OXIDATION

A first transformation of L-azetidine-2-carboxylic acid (1) into optically active monocyclic N-unsubstituted β-lactam, (2S)-2-methoxycarbonyl-4-azetidinone (6), has been developed via ruthenium tetroxide (RuO4) oxidation process.