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1112977-84-0

DAz-1 is a cell-permeable chemical probe specifically designed to react with sulfenic acid-modified proteins. It plays a crucial role in the study of redox-sensitive cysteine residues in proteins, which act as sensors of reactive oxygen species (ROS) and serve as molecular switches. The azido group of DAz-1 allows for selective conjugation to phosphineor alkynyl-derivatized reagents, such as biotin or various fluorophores, enabling the subsequent analysis of the labeled proteins. Although DAz-1 is less sensitive for sulfenic acid detection compared to its analog DAz-2, it remains a valuable tool in the field of redox biology and protein modification research.

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  • 1112977-84-0 Structure

  • Basic information

    1. Product Name: DAz-1
    2. Synonyms: DAz-1;N-(3-azidopropyl)-3,5-dioxocyclohexane-1-carboxamide
    3. CAS NO:1112977-84-0
    4. Molecular Formula: C10H14N4O3
    5. Molecular Weight: 238.24316
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1112977-84-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: DAz-1(CAS DataBase Reference)
    10. NIST Chemistry Reference: DAz-1(1112977-84-0)
    11. EPA Substance Registry System: DAz-1(1112977-84-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1112977-84-0(Hazardous Substances Data)

1112977-84-0 Usage

Uses

Used in Redox Biology Research:
DAz-1 is used as a chemical probe for identifying and studying sulfenic acid-modified proteins, which are essential in redox-sensitive signaling pathways and molecular switches. Its ability to react specifically with these modified proteins makes it a valuable tool for understanding the role of cysteine residues in protein function and redox regulation.
Used in Protein Modification Analysis:
DAz-1 is used as a detection agent for the reversible oxidation of cysteine residues in proteins. By conjugating with phosphineor alkynyl-derivatized reagents, such as biotin or fluorophores, DAz-1 allows researchers to analyze and track the labeled proteins, providing insights into protein modification and signal transduction mechanisms.
Used in Drug Development:
Although not explicitly mentioned in the provided materials, DAz-1's ability to selectively label and detect sulfenic acid-modified proteins could potentially be applied in the development of drugs targeting specific redox-sensitive pathways or proteins. This could lead to the discovery of novel therapeutic agents for various diseases and conditions related to redox regulation and protein function.

Check Digit Verification of cas no

The CAS Registry Mumber 1112977-84-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,1,2,9,7 and 7 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1112977-84:
(9*1)+(8*1)+(7*1)+(6*2)+(5*9)+(4*7)+(3*7)+(2*8)+(1*4)=150
150 % 10 = 0
So 1112977-84-0 is a valid CAS Registry Number.

1112977-84-0Downstream Products

1112977-84-0Relevant articles and documents

Facile synthesis and biological evaluation of a cell-permeable probe to detect redox-regulated proteins

Seo, Young Ho,Carroll, Kate S.

, p. 356 - 359 (2011/03/20)

We have developed an improved synthesis for the cell-permeable, sulfenic acid probe DAz-1. Using DAz-1, we detect sulfenic acid modifications in the cell-cycle regulatory phosphatase Cdc25A. In addition, we show that DAz-1 has superior potency in cells co

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