- Electrochemical deamination of alkoxyamine lactams
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An anodic electrochemical deamination of 3-alkoxyamine lactams to 3-hydroxy lactams was developed. The electrochemical transformation was achieved by using reticulated vitreous carbon (RVC) and stainless-steel electrodes in aqueous ethanolic solution of NaOAc. This simple electrochemical procedure represents an ecofriendly alternative to the traditional chemical reductive deamination, which requires of a large excess of Zn (up to 40 equivalents) and acetic acid.
- Romero-Iba?ez, Julio,Cruz-Gregorio, Enrique,Cruz-Gregorio, Silvano,Quintero, Leticia,Bernès, Sylvain,González-Perea, Mario,Sartillo-Piscil, Fernando
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- Transition Metal-Free Selective Double sp3 C-H Oxidation of Cyclic Amines to 3-Alkoxyamine Lactams
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The first chemical method for selective dual sp3 C-H functionalization at the alpha-and beta positions of cyclic amines to their corresponding 3-alkoxyamine lactams is reported. Unlike traditional Cα-H oxidation of amines to amides mediated by transition metals, the present protocol, which involves the use of NaClO2/TEMPO/NaClO in either aqueous or organic solvent, not only allows the Cα-H oxidation but also the subsequent functionalization of the unreactive β-methylene group in an unprecedented tandem fashion and using environmentally friendly reactants.
- Osorio-Nieto, Urbano,Chamorro-Arenas, Delfino,Quintero, Leticia,H?pfl, Herbert,Sartillo-Piscil, Fernando
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p. 8625 - 8632
(2016/09/28)
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- Chemoenzymatic enantioselective synthesis of 3-hydroxy-2-pyrrolidinones and 3-hydroxy-2-piperidinones
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The enantioselective synthesis of 3-hydroxypyrrolidin-2-ones and 3-hydroxy piperidin-2-ones has been carried out in high enantiomeric excess employing immobilized lipase from Pseudomonas cepacia.
- Kamal, Ahmed,Ramana, K. Venkata,Ramana, A. Venkata,Babu, A. Hari
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p. 2587 - 2594
(2007/10/03)
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- Synthesis and Serotonin-Receptor Activity of Substituted 1-Oxo-1,2,3,4-tetrahydro-&β-carbolines
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2,3-Dihydroxypyridine is used as a starting material for the synthesis of donor and acceptor substituted 1-oxo-1,2,3,4-tetrahydro-β-carbolines via Fisher indole cyclisation.An alkaloid from Alstonia venenata is prepared.All compounds inclusive strychnocarpine show low affinity to the serotonine receptor. - Key words: 3-Hydroxy-2-pyridone, Strychnocarpine Derivatives, 5-Hydroxytryptamine Receptor Stimulators
- Herdeis, Claus,Bissinger, Gerhard
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p. 785 - 790
(2007/10/02)
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