111492-68-3

Usage

Uses

Used in Scientific Research:
3-PPP is used as a research chemical for studying its effects on the central nervous system, particularly its interactions with neurotransmitter receptors. Its potent dopamine reuptake inhibitory action makes it a valuable tool in understanding the mechanisms of psychoactive substances and their impact on the brain.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 3-PPP is used as a lead compound for the development of new medications targeting the dopaminergic system. Its ability to inhibit dopamine reuptake could potentially be harnessed to treat conditions such as attention deficit hyperactivity disorder (ADHD) and other disorders related to dopamine imbalances.
Used in Neurotransmitter Receptor Studies:
3-PPP is utilized as a research tool in the study of neurotransmitter receptors, specifically those involved in the dopaminergic system. Its interactions with these receptors can provide insights into the development of new drugs and therapies for neurological and psychiatric conditions.

Upstream product

• 4783-65-7 N-benzyl-2-piperidinone 
• 2905-56-8 N-Benzylpiperidine 
• 19365-08-3 3-hydroxypiperidin-2-one 
• 16867-04-2 dihydroxypyridine 
• 100-46-9 benzylamine 
• 77868-79-2 N-benzyl-2,5-dibromopentanamide 
• 77868-86-1 3-bromo-1-benzyl-2-piperidinone 
• 89180-84-7 2,5-Dibromopentanoic Acid Bromide 
• 614754-21-1 3-acetoxy-1-benzyl-2-piperidinone 
• 111492-67-2 1-benzyl-3-benzyloxy-2-piperidone 

Downstream Products

• 14813-01-5 1-benzyl-3-hydroxypiperidine 
• 111492-76-3 1-Benzyl-3-[(3-trifluoromethyl-phenyl)-hydrazono]-piperidin-2-one 
• 111492-77-4 1-Benzyl-3-[(4-trifluoromethyl-phenyl)-hydrazono]-piperidin-2-one 
• 111492-73-0 1-Benzyl-3-[(3-methoxy-phenyl)-hydrazono]-piperidin-2-one 
• 111492-74-1 1-Benzyl-3-[(4-fluoro-phenyl)-hydrazono]-piperidin-2-one 
• 111492-78-5 1-benzyl-3-phenylhydrazono-2-piperidone 
• 111492-84-3 6-Fluoro-2,3,4,9-tetrahydro-2-(phenylmethyl)-1H-pyrido<3,4-b>indol-1-one 
• 111492-86-5 N_b-benzyl-1,2,3,4-tetrahydro-β-carbolin-1-one 
• 111492-69-4 1-(phenylmethyl)-2,3-piperidinedione 

Relevant academic research and scientific papers

Electrochemical deamination of alkoxyamine lactams

An anodic electrochemical deamination of 3-alkoxyamine lactams to 3-hydroxy lactams was developed. The electrochemical transformation was achieved by using reticulated vitreous carbon (RVC) and stainless-steel electrodes in aqueous ethanolic solution of NaOAc. This simple electrochemical procedure represents an ecofriendly alternative to the traditional chemical reductive deamination, which requires of a large excess of Zn (up to 40 equivalents) and acetic acid.

Transition Metal-Free Selective Double sp3 C-H Oxidation of Cyclic Amines to 3-Alkoxyamine Lactams

The first chemical method for selective dual sp3 C-H functionalization at the alpha-and beta positions of cyclic amines to their corresponding 3-alkoxyamine lactams is reported. Unlike traditional Cα-H oxidation of amines to amides mediated by transition metals, the present protocol, which involves the use of NaClO2/TEMPO/NaClO in either aqueous or organic solvent, not only allows the Cα-H oxidation but also the subsequent functionalization of the unreactive β-methylene group in an unprecedented tandem fashion and using environmentally friendly reactants.

Chemoenzymatic enantioselective synthesis of 3-hydroxy-2-pyrrolidinones and 3-hydroxy-2-piperidinones

The enantioselective synthesis of 3-hydroxypyrrolidin-2-ones and 3-hydroxy piperidin-2-ones has been carried out in high enantiomeric excess employing immobilized lipase from Pseudomonas cepacia.

Synthesis and Serotonin-Receptor Activity of Substituted 1-Oxo-1,2,3,4-tetrahydro-&β-carbolines

2,3-Dihydroxypyridine is used as a starting material for the synthesis of donor and acceptor substituted 1-oxo-1,2,3,4-tetrahydro-β-carbolines via Fisher indole cyclisation.An alkaloid from Alstonia venenata is prepared.All compounds inclusive strychnocarpine show low affinity to the serotonine receptor. - Key words: 3-Hydroxy-2-pyridone, Strychnocarpine Derivatives, 5-Hydroxytryptamine Receptor Stimulators