- Structure-activity relationship studies on rhodamine B-based fluorogenic probes and their activation by anticancer platinum(II) compounds
-
Fluorescence microscopy has emerged as an attractive technique for imaging intracellular Pt species arising from exposure to clinical anticancer drugs such as cisplatin. A rhodamine-B based fluorogenic probe termed Rho-DDTC can be activated selectively in the presence of Pt(II) compounds, and possesses the ability to discriminate Pt(II) species from Pt(IV) carboxylate prodrug complexes, thereby providing a unique platform to investigate the reduction of these Pt(IV) complexes after cell entry. In this report, we seek to establish the mechanism of activation of Rho-DDTC through a structure-activity relationship study on its structural analogues.
- Ong, Jun Xiang,Yap, Jian Yu,Yap, Siew Qi,Ang, Wee Han
-
-
Read Online
- A rhodamine-hydroxamic acid-based fluorescent probe for hypochlorous acid and its applications to Biological imagings
-
A new rhodamine-hydroxamic acid-based fluorescent chemosensor for the rapid detection of HOCl in aqueous media was developed. The system, which utilizes an irreversible HOCl-promoted oxidation reaction, responds instantaneously at room temperature with li
- Yang, Young-Keun,Cho, Hyungseoph Jason,Lee, Jihyun,Shin, Injae,Tae, Jinsung
-
-
Read Online
- A dual functional probe for "turn-on" fluorescence response of Pb2+ and colorimetric detection of Cu2+ based on a rhodamine derivative in aqueous media
-
A dual functional probe L based on rhodamine was devised and synthesized. Probe L can sense Pb2+ and Cu2+ in aqueous solution through two approaches: a significant fluorescence enhancement caused by Pb2+ and a visible color change from colorless to orchid induced by Cu2+. Competitive experiments showed that probe L had high fluorescence sensitivity for Pb2+ and excellent colorimetric selectivity for Cu2+ over many environmentally relevant ions. The mechanisms of L for sensing Pb2+ and Cu2+ have been well demonstrated by ESI-MS, 1H NMR titration, IR, the crystal structure of L-Pb2+ and density functional theory calculation of L-Cu2+. In addition, fluorescence image detection of Pb2+ in living cells displayed an enhanced fluorescence effect.
- Li, Min,Jiang, Xiu-Juan,Wu, Hui-Hui,Lu, Hong-Lin,Li, Hai-Yang,Xu, Hong,Zang, Shuang-Quan,Mak, Thomas C. W.
-
-
Read Online
- Ring expansion of spiro-thiolactam in rhodamine scaffold: Switching the recognition preference by adding one atom
-
A new rhodamine spiro scaffold with a six-membered reactive ring was developed by inserting a nitrogen atom in the known probe rhodamine B spiro thiohydrazide, which switched the recognition preference of the probe from Hg2+ to Cu2+.
- Wu, Cong,Bian, Qing-Na,Zhang, Bian-Guo,Cai, Xin,Zhang, Shu-Dong,Zheng, Hong,Yang, Shi-Yao,Jiang, Yun-Bao
-
-
Read Online
- Hg2+-selective dual signaling probe based on a thio-functionalized rhodamine B hydroxamic acid
-
Abstract A new Hg2+-selective signaling system based on a thio-functionalized rhodamine B hydroxamic acid was investigated. A thio-analogue of rhodamine B hydroxamic acid had a distinct Hg2+-selective signaling behavior in aqueous solution, whereas its parent hydroxamic acid was completely unreactive toward any metal ions. Selective chromogenic and fluorogenic signaling of Hg2+ by the thio-functionalized rhodamine B hydroxamic acid in aqueous solution was possible with a detection limit of 1.0 × 10-6 M. Hg2+ determination based on paper test strips was conducted as a practical application.
- Jeong, Yong Ae,Choi, Jiyoung,Chang, Suk-Kyu
-
-
Read Online
- Determination of thallium(iii) ions by oxidative hydrolysis of rhodamine-hydroxamate
-
Thallium ions are widely used in chemical and industrial applications but are very toxic. Through this research, a novel dual signaling probe that is based on an oxidative cleavage reaction is examined. The probe showed selective and sensitive optical sig
- Yoo, Jae Hoon,Lee, Yu Jeong,Lee, Kang Min,Choi, Myung Gil,Park, Tae Jung,Chang, Suk-Kyu
-
-
Read Online
- A fluorescent probe for investigating the activation of anticancer platinum(IV) prodrugs based on the cisplatin scaffold
-
Watching closely: A fluorescent probe was engineered to detect the clinically relevant platinum drug cisplatin within a complex cellular environment, thus providing a direct means for visualizing its cell entry and the activation of platinum(IV) prodrugs in cancer cells. Copyright
- Montagner, Diego,Yap, Siew Qi,Ang, Wee Han
-
-
Read Online
- Cyclen-conjugated rhodamine hydroxamate as Pd2+-specific fluorescent chemosensor
-
Youa're my hydroxamate: A chemosensor based on rhodamine hydroxamate with cyclen-tri (tert-butyl ester) and pyridine moiety binding units binds selectively with Pd2+ to induce a strong fluorescence enhancement and color change in aqueous soluti
- Kim, Hyemi,Moon, Kyung-Soo,Shim, Soyoung,Tae, Jinsung
-
-
Read Online
- A six-membered-ring incorporated Si-rhodamine for imaging of copper(II) in lysosomes
-
The regulation of copper homeostasis in lysosomes of living cells is closely related to various physiological and pathological processes. Thus, it is of urgent need to develop a fluorescent probe for selectively and sensitively monitoring the location and
- Wang, Baogang,Cui, Xiaoyan,Zhang, Zhiqiang,Chai, Xiaoyun,Ding, Hao,Wu, Qiuye,Guo, Zhongwu,Wang, Ting
-
-
Read Online
- Fluorescent probe for detecting hypochlorous acid, and synthesis method and application thereof
-
The invention provides a fluorescent probe for detecting hypochlorous acid, and belongs to the field of organic small molecular fluorescent probe, wherein the fluorescent probe has the structural formula defined in the specification. The fluorescent probe is obtained by reaction of reaction products of rhodamine B and hydroxylamine hydrochloride with reaction products of 7-diethylaminocoumarin-3-carboxylic acid and N-hydroxysuccinimide at room temperature. The fluorescent probe for detecting hypochlorous acid has the advantages of fast detection speed, good selectivity and strong anti-interference ability to other molecules. The synthesis of the fluorescent probe can be completed in only a few steps, and the post-processing process is relatively simple. The fluorescent probe can be used asa specific indicator for displaying hypochlorous acid molecules in aqueous solutions and biological cells, can be used for real-time qualitative visual colorimetric detection and has broad application prospects in the field of biomolecular detection.
- -
-
Paragraph 0017
(2019/02/13)
-
- A mild method for synthesizing carboxylic acids by oxidation of aldoximes using hypervalent iodine reagents
-
A mild oxidation method for the conversion of aldoximes to carboxylic acids was developed mediated by hypervalent iodine reagents. This method covers a wide range of functionalized aldoximes and proceeds under mild conditions, utilizing PhI(OH)OTs as an oxidant.
- Nakamura, Akira,Kanou, Hodaka,Tanaka, Junki,Imamiya, Akira,Maegawa, Tomohiro,Miki, Yasuyoshi
-
supporting information
p. 541 - 544
(2018/02/07)
-
- Fluorescent probes based on O-glycoside, and synthetic methods and application thereof
-
The invention discloses fluorescent probes based on O-glycoside, and synthetic methods and application thereof. The fluorescent probes are prepared through four-step reactions, and the synthetic methods have the characteristics of usage of cheap and easily available reaction raw materials, few reaction steps, high yield, etc. The invention discloses a plurality of purposes of the fluorescent probes based on O-glycoside, including 1, detection of iron ions on the basis of the characteristic that the fluorescent probes are of spiro structures and have no fluorescence, but emits strong red fluorescence after addition of iron ions; 2, detection of a Job's Plot curve which is utilized for analyzing the bonding ratios of the probes to iron ions; and 3, ionic competition experiments, which are used for detection of the competitiveness of the probes in the presence of a plurality of other common cations.
- -
-
Paragraph 0033; 0039-0042
(2018/05/16)
-
- Visual and fluorogenic detection of a nerve agent simulant via a Lossen rearrangement of rhodamine-hydroxamate
-
A visual and fluorogenic detection method for a nerve agent simulant was developed based on a Lossen rearrangement of rhodamine-hydroxamate, in the presence of diethyl chlorophosphate, under alkaline conditions.
- Han, Shoufa,Xue, Zhongwei,Wang, Zhen,Wen, Ting Bin
-
supporting information; experimental part
p. 8413 - 8415
(2011/02/23)
-