- SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4-BENZAMIDE HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
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Industrial synthesis process for, and crystalline form I of, the compound of formula (I): and also crystalline form I of the associated free base. Medicinal products containing the same which are useful in the treatment of disorders of the histaminergic system.
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Page/Page column 4
(2013/02/27)
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- AZABICYCLO[3.1.0]HEX-2-YL COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
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Compounds of formula: wherein: ALK represents an alkylene chain,W represents a group wherein R and R′ are as defined in the description. Medicinal products containing the same which are useful in treating cognitive disorders associated with cerebral aging
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Page/Page column 4
(2012/11/13)
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- Azabicyclo[3.2.0] hept-3-yl compounds, a process for their preparation and pharmaceutical compositions containing them
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Compounds of formula (I): wherein: ALK represents an alkylene chain,W represents a group wherein R and R′ are as defined in the description. Medicinal products containing the same which are useful in the treatment of conditions associated with central his
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Page/Page column 3
(2011/06/24)
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- Phenyl-oxazoles, a new family of inverse agonists at the H3 histamine receptor
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(Chemical Equation Presented) Drug design: Oxazoles and thiazoles were designed and synthesised based on previously reported ligands of the 3rd histamine receptor (H3R). The aminopropoxy-phenyl-oxazole chemotype was identified as a promising H
- Denonne, Frederic,Atienzar, Franck,Celanire, Sylvain,Christophe, Bernard,Delannois, Frederique,Delaunoy, Christel,Delporte, Marie-Laure,Durieu, Vronique,Gillard, Michel,Lallemand, Bndicte,Lamberty, Yves,Lorent, Genevive,Vanbellinghen, Alain,Van Houtvin, Nathalie,Verbois, Valrie,Provins, Laurent
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scheme or table
p. 206 - 212
(2010/12/24)
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- Azabicylic compounds, a process for their preparation and pharmaceutical compositions containing them
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Compounds of formula (I): wherein: ALK represents an alkylene chain,W represents a group selected from wherein R and R′ are as defined in the description. Medicinal products containing the same which are useful in the treatment of cognitive and psycho-beh
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Page/Page column 3
(2009/12/27)
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- COMPOUNDS COMPRISING AN OXAZOLE OR THIAZOLE MOIETY, PROCESSES FOR MAKING THEM, AND THEIR USES
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The present invention relates to compounds comprising an oxazole or thiazole moiety of formula (I), processes for preparing them, pharmaceutical compositions comprising said compounds and their uses as H3 -receptor ligands, Formula (I), wherein
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Page/Page column 84
(2010/11/24)
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- Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment
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A method of inhibiting Type 1 allergic responses in a living animal body with substituted heterocyclic amines is disclosed wherein the active agents are expressed generally by the formula which includes certain known and certain known compounds: STR1 wherein P is zero, one or two; m is one to six inclusive; A is selected from hydrogen, hydroxy or cyano; d is zero or one; Q is --CH--, CH2 -- or STR2 n is zero or one and when Q is --CH-- and n is one, a double bond is formed with one of the adjacent carbons but not both at the same time, and when n and d are zero at the same time, a double bond is formed between the α carbon and a carbon of the central heterocyclic amine ring; Ar, D and R are selected from phenyl, substituted phenyl, pyridinyl, thienyl, furanyl or naphthyl and in addition, R may have the values benzyl, substituted benzyl, cycloalkyl or loweralkyl and D may additionally have the values: 2H-1-benzopyran-2-one,4-oxo-4H-1-benzopyran-2-carboxylic acid loweralkyl ester, 2,3-dihydro-4H-1-benzopyran-4-one, 1,4-benzodioxanloweralkyl-2-yl or 1,1'-biphenyl-4-yl and the pharmaceutically acceptable salts thereof.
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- Synthesis and Antiallergy Activity of 4-(Diarylhydroxymethyl)-1-piperidines and Structurally Related Compounds
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A series of 4-(diarylhydroxymethyl)-1-piperidines was synthesized and evaluated for antiallergy activity.Several analogues had potent activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity.In particular 1--1-piperidinyl>propoxy>-3-methoxyphenyl>ethanone (1, AHR-5333) was more potent than oxatomide and terfenadine in this assay.
- Walsh, David A.,Franzyshen, Stephen K.,Yanni, John M.
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p. 105 - 118
(2007/10/02)
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