111659-88-2

Basic information

• Product Name: 1-(2-naphthylsulfonyl)pyrrolidine
• Synonyms: 1-(2-naphthylsulfonyl)pyrrolidine;1-(naphthalen-2-ylsulfonyl)pyrrolidine
• CAS NO: 111659-88-2
• Molecular Formula: C14H15NO2S
• Molecular Weight: 261.3394
• Mol File: 111659-88-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-(2-naphthylsulfonyl)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-naphthylsulfonyl)pyrrolidine(111659-88-2)
• EPA Substance Registry System: 1-(2-naphthylsulfonyl)pyrrolidine(111659-88-2)

Safety Data

• Hazardous Substances Data: 111659-88-2(Hazardous Substances Data)

Usage

Chemical structure

A pyrrolidine ring attached to a naphthylsulfonyl group.

Usage

Commonly used as a reagent in organic synthesis.

Application

Particularly used in the preparation of various pharmaceutical compounds.

Selective functionalization

The naphthylsulfonyl group allows for selective functionalization of the pyrrolidine ring.

Building block

It is a valuable building block in the production of diverse heterocyclic compounds.

Chemical modifications

The presence of the sulfonyl group provides a site for potential chemical modifications.

Versatility

1-(2-naphthylsulfonyl)pyrrolidine is a versatile reagent with a wide range of potential applications.

Research and drug discovery

It has potential applications in chemical research and drug discovery.

Upstream product

• 7335-06-0 1-ethylpyrrolidine 
• 10151-46-9 2-naphthylsulfonyl hydrazide 
• 93-11-8 2-Naphthalenesulfonyl chloride 
• 91-60-1 2-Naphthalenethiol 
• 5586-15-2 bis(2-naphthyl)disulfide 
• 123-75-1 pyrrolidine 

Relevant articles and documents

Iodine-catalyzed sulfonylation of sulfonyl hydrazides with: Tert -amines: A green and efficient protocol for the synthesis of sulfonamides

This study provides a direct, sustainable and eco-friendly method for the synthesis of various sulfonamides via the sulfonylation of sulfonyl hydrazides with tert-amines. The method utilizes sulfonyl hydrazides to oxidize and couple with tertiary amines through selective cleavage of C-N bonds. In this reaction, molecular iodine was used as the catalyst and t-butyl hydroperoxide was used as the oxidant.

TBAI-catalyzed selective synthesis of sulfonamides and β-aryl sulfonyl enamines: coupling of arenesulfonyl chlorides and sodium sulfinates with tert-amines

A simple, practical and metal-free method has been developed for the synthesis of sulfonamides and β-arylsulfonyl enamines via the selective cleavage of C-N and C-H bonds through the iodine-catalyzed oxidation of arenesulfonyl chlorides and sodium sulfinates with tert-amines. The method uses commercially available inexpensive catalysts and oxidants, and has a wide substrate scope and operational simplicity.

METHOD OF INHIBITING APOLIPOPROTEIN-E EXPRESSION WHILE INCREASING EXPRESSION OF AT LEAST ONE OF LDL-RECEPTOR PROTEIN OR ABCA1 PROTEIN COMPRISING ADMINISTERING A SMALL COMPOUND

This invention offers an effective method of decreasing expression of apolipoprotein E and increasing expression of at least one of either LDL-receptor protein or AbcA1 protein including selecting mammalian cells expressing apoE and at least one of either LDL-receptor protein or AbcA1 protein, contacting the mammalian cell with an effective amount of a compound having general formula (I) or general formula (II) in an amount sufficient to decrease expression of the apoE and increase expression of at least one of the LDL-receptor protein or the AbcA1 protein in the mammalian cell.

Convenient one-pot synthesis of sulfonamides from thiols and disulfides using 1,3-dichloro-5,5-dimethylhydantoin (DCH)

A convenient synthesis of sulfonamides from thiols and disulfides is described. In situ preparation of sulfonyl chlorides from thiols is accomplished by oxidation with 1,3-dichloro-5,5-dimethylhydantoin (DCH) under Nbenzyl-trimethylammonium chloride and water. The sulfonyl chlorides are then further allowed to react with excess amine in the same reaction vessel.