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123-75-1

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Pyrrolidine/Tetrahydro pyrrole with competitive price CAS 123-75-1
Cas No: 123-75-1
USD $ 10.0-10.0 / Kilogram 1 Kilogram 3000 Metric Ton/Month Crovell Biotech (Hebei) Co., Ltd. Contact Supplier
Pyrrolidine CAS 123-75-1 C4H10N
Cas No: 123-75-1
USD $ 20.0-20.0 / Metric Ton 20 Metric Ton 20 Metric Ton/Day Changsha Easchem Co.,Limited Contact Supplier
Tetrahydro pyrrole
Cas No: 123-75-1
No Data 1 Gram 2 Metric Ton/Day Hangzhou Dayangchem Co., Ltd. Contact Supplier
Tetrahydro pyrrole CAS 123-75-1 Pyrrolidine supplier
Cas No: 123-75-1
USD $ 75.0-100.0 / Kilogram 1 Kilogram 15 Metric Ton/Month HUBEI AOKS BIO-TECH CO.,LTD Contact Supplier
Pyrrolidine
Cas No: 123-75-1
USD $ 0.26-0.4 / Gram 10 Gram 200 Metric Ton/Month Hebei Huanhao Biotechnology Co.,Ltd Contact Supplier
Pyrrolidine
Cas No: 123-75-1
USD $ 0.9-1.2 / Gram 10 Gram 500 Kilogram/Week Hebei Ruishun Trade Co.,Ltd Contact Supplier
Pyrrolidine
Cas No: 123-75-1
USD $ 10.0-10.0 / Metric Ton 200 Metric Ton 5-10 Metric Ton/Month Hangzhou Weck Chemical Industry Co., Ltd. Contact Supplier
Hot sale Tetrahydro pyrrole CAS:123-75-1 with high purity
Cas No: 123-75-1
USD $ 1.0-1.0 / Kilogram 1 Kilogram 10000 Kilogram/Month Chemical Co.Ltd Contact Supplier
Pyrrolidine CAS NO.123-75-1
Cas No: 123-75-1
USD $ 1.0-1.0 / Kilogram 1 Kilogram 10 Metric Ton/Month Hebei Xibaijie Biotechnology Co.,Ltd Contact Supplier
Tetrahydro Pyrrole CAS NO.123-75-1
Cas No: 123-75-1
USD $ 1.0-3.0 / Kilogram 1 Kilogram 10 Kilogram/Day Hebei yanxi chemical co.,LTD. Contact Supplier

123-75-1 Usage

Uses

A heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs).

Pyrrolidine

Pyrrolidine is also known as tetrahydro pyrrole, and it is colorless to pale yellow liquid with a pungent ammonia odor, smoke in air, and toxic. The relative density is 0.8618, the boiling point is 88~89℃, refractive index is 1.4402 (28℃). It is strong alkaline, miscible with water, soluble in alcohol, ether and chloroform.
Pyrrole can synthesize pyrrolidine by catalytic hydrogenation, pyrrolidine present in tobacco and carrot leaves, and it is natural substances, the molecular structure of pyrrolidine is cyclic secondary amine, which is generally the same with the reaction of amine. Pyrrolidine is an important organic chemical raw material, it can be used for drug preparation, fungicides and insecticides.
Preparation:
1. 1,4-butanediol as the raw material, dehydrate to tetrahydrofuran, and then reacte with ammonia, then pyrrolidine can be obtained.
2. Furan as raw material, react with ammonia in the catalyst at 400℃ can obtain tetrahydro pyrrole.
3. The 1,4-dichloro-butane as raw material, react with ammonia, pyrrolidine can be obtained.
4. Pyrrole as raw material, with the catalyst of rhodium or ruthenium, with the reaction of reduction can obtain .
The above information is edited by the chemicalbook of Wang Xiaodong.

Reactivity Profile

Tetrahydro pyrrole neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. An explosion occurred when a mixture of Tetrahydro pyrrole, benzaldehyde, and propionic acid was heated in an attempt to form porphyrins.

Purification Methods

Dry pyrrolidine with BaO or sodium, then fractionally distil it, under N2, through a Todd column (p 11) packed with glass helices. [Beilstein 20 H 159, 20 I 36, 20 II 79, 20 III/IV 2072, 20/1 V 162.]

Uses

Pharmaceutical raw materials, organic synthesis, special organic solvents.
It can be used for the preparation of drugs, fungicides, insecticides, etc.

Chemical Properties

colourless to pale yellow liquid with a penetrating

Toxicity grading

Highly toxic.

Category

Flammable liquid.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Definition

ChEBI: A cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Acute toxicity

Oral-rat LD50: 300 mg/kg; Oral-Mouse LD50: 450 mg/kg.

Occupational standards

STEL 0.1 mg /m.

Flammability hazard characteristics

When exposed to fire, high temperature, oxidant, it is flammable; when heat, toxic nitric oxide gas can produce.

General Description

A colorless to pale yellow liquid with an ammonia-like odor. Flash point 37°F. Density 0.85 g / cm3. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.

Storage Characteristics

Treasury ventilation low-temperature drying; oxidants, acids stored separately.

Extinguishing agent

Dry, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.

Air & Water Reactions

Highly flammable. Very soluble in water.

Chemical Properties

It is colorless, transparent liquid with special smell. When exposed to light or moist air, it can turn yellow. It can be soluble in water, ethanol. It is corrosive and flammable. Boiling point is 87.0~89.0℃.
InChI:InChI=1/C4H9N/c1-2-4-5-3-1/h5H,1-4H2/p+1

123-75-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (P73803)  Pyrrolidine  99% 123-75-1 P73803-2.5L 1,730.43CNY Detail
Aldrich (P73803)  Pyrrolidine  99% 123-75-1 P73803-500ML 349.83CNY Detail
Aldrich (P73803)  Pyrrolidine  99% 123-75-1 P73803-100ML 259.74CNY Detail
Aldrich (P73803)  Pyrrolidine  99% 123-75-1 P73803-5ML 189.54CNY Detail
Aldrich (394238)  Pyrrolidine  ≥99.5%, purified by redistillation 123-75-1 394238-1L 3,328.65CNY Detail
Aldrich (394238)  Pyrrolidine  ≥99.5%, purified by redistillation 123-75-1 394238-100ML 672.75CNY Detail
Sigma-Aldrich (83240)  Pyrrolidine  puriss. p.a., ≥99.0% 123-75-1 83240-500ML 907.92CNY Detail
Sigma-Aldrich (83240)  Pyrrolidine  puriss. p.a., ≥99.0% 123-75-1 83240-100ML 328.77CNY Detail
Sigma-Aldrich (83240)  Pyrrolidine  puriss. p.a., ≥99.0% 123-75-1 83240-25ML 176.67CNY Detail
Alfa Aesar (A14852)  Pyrrolidine, 99%    123-75-1 2500ml 1523.0CNY Detail
Alfa Aesar (A14852)  Pyrrolidine, 99%    123-75-1 500ml 429.0CNY Detail
Alfa Aesar (A14852)  Pyrrolidine, 99%    123-75-1 100ml 223.0CNY Detail

123-75-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name pyrrolidine

1.2 Other means of identification

Product number -
Other names Tetrahydro pyrrole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123-75-1 SDS

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