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Tetrahydro pyrrole
Cas No: 123-75-1
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Good Quality Pyrrolidine Tetrahydro Pyrrole, source factory with best price
Cas No: 123-75-1
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Pyrrolidine CAS 123-75-1 C4H10N
Cas No: 123-75-1
USD $ 20.0-20.0 / Metric Ton 20 Metric Ton 20 Metric Ton/Day Changsha Easchem Co.,Limited Contact Supplier
Pyrrolidine/Tetrahydro pyrrole CAS 123-75-1
Cas No: 123-75-1
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Pyrrolidine liqiud CAS:123-75-1 china supplier high quality
Cas No: 123-75-1
USD $ 45.0-55.0 / Milliliter 1 Milliliter 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Tetrahydro pyrrole /Tetrahydropyrrole /Pyrrolidine
Cas No: 123-75-1
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Pyrrolidine
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Pyrrolidine CAS:123-75-1 from Fandachem
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Tetrahydro pyrrole
Cas No: 123-75-1
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Tetrahydro pyrrole 99%
Cas No: 123-75-1
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123-75-1 Usage

Uses

A heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs).

Pyrrolidine

Pyrrolidine is also known as tetrahydro pyrrole, and it is colorless to pale yellow liquid with a pungent ammonia odor, smoke in air, and toxic. The relative density is 0.8618, the boiling point is 88~89℃, refractive index is 1.4402 (28℃). It is strong alkaline, miscible with water, soluble in alcohol, ether and chloroform.
Pyrrole can synthesize pyrrolidine by catalytic hydrogenation, pyrrolidine present in tobacco and carrot leaves, and it is natural substances, the molecular structure of pyrrolidine is cyclic secondary amine, which is generally the same with the reaction of amine. Pyrrolidine is an important organic chemical raw material, it can be used for drug preparation, fungicides and insecticides.
Preparation:
1. 1,4-butanediol as the raw material, dehydrate to tetrahydrofuran, and then reacte with ammonia, then pyrrolidine can be obtained.
2. Furan as raw material, react with ammonia in the catalyst at 400℃ can obtain tetrahydro pyrrole.
3. The 1,4-dichloro-butane as raw material, react with ammonia, pyrrolidine can be obtained.
4. Pyrrole as raw material, with the catalyst of rhodium or ruthenium, with the reaction of reduction can obtain .
The above information is edited by the chemicalbook of Wang Xiaodong.

Reactivity Profile

Tetrahydro pyrrole neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. An explosion occurred when a mixture of Tetrahydro pyrrole, benzaldehyde, and propionic acid was heated in an attempt to form porphyrins.

Purification Methods

Dry pyrrolidine with BaO or sodium, then fractionally distil it, under N2, through a Todd column (p 11) packed with glass helices. [Beilstein 20 H 159, 20 I 36, 20 II 79, 20 III/IV 2072, 20/1 V 162.]

Uses

Pharmaceutical raw materials, organic synthesis, special organic solvents.
It can be used for the preparation of drugs, fungicides, insecticides, etc.

Chemical Properties

colourless to pale yellow liquid with a penetrating

Toxicity grading

Highly toxic.

Category

Flammable liquid.

Fire Hazard

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Definition

ChEBI: A cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family.

Health Hazard

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Acute toxicity

Oral-rat LD50: 300 mg/kg; Oral-Mouse LD50: 450 mg/kg.

Occupational standards

STEL 0.1 mg /m.

Flammability hazard characteristics

When exposed to fire, high temperature, oxidant, it is flammable; when heat, toxic nitric oxide gas can produce.

General Description

A colorless to pale yellow liquid with an ammonia-like odor. Flash point 37°F. Density 0.85 g / cm3. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.

Storage Characteristics

Treasury ventilation low-temperature drying; oxidants, acids stored separately.

Extinguishing agent

Dry, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.

Air & Water Reactions

Highly flammable. Very soluble in water.

Chemical Properties

It is colorless, transparent liquid with special smell. When exposed to light or moist air, it can turn yellow. It can be soluble in water, ethanol. It is corrosive and flammable. Boiling point is 87.0~89.0℃.
InChI:InChI=1/C4H9N/c1-2-4-5-3-1/h5H,1-4H2/p+1

123-75-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (P73803)  Pyrrolidine  99% 123-75-1 P73803-2.5L 1,730.43CNY Detail
Aldrich (P73803)  Pyrrolidine  99% 123-75-1 P73803-500ML 349.83CNY Detail
Aldrich (P73803)  Pyrrolidine  99% 123-75-1 P73803-100ML 259.74CNY Detail
Aldrich (P73803)  Pyrrolidine  99% 123-75-1 P73803-5ML 189.54CNY Detail
Aldrich (394238)  Pyrrolidine  ≥99.5%, purified by redistillation 123-75-1 394238-1L 3,328.65CNY Detail
Aldrich (394238)  Pyrrolidine  ≥99.5%, purified by redistillation 123-75-1 394238-100ML 672.75CNY Detail
Sigma-Aldrich (83240)  Pyrrolidine  puriss. p.a., ≥99.0% 123-75-1 83240-500ML 907.92CNY Detail
Sigma-Aldrich (83240)  Pyrrolidine  puriss. p.a., ≥99.0% 123-75-1 83240-100ML 328.77CNY Detail
Sigma-Aldrich (83240)  Pyrrolidine  puriss. p.a., ≥99.0% 123-75-1 83240-25ML 176.67CNY Detail
Alfa Aesar (A14852)  Pyrrolidine, 99%    123-75-1 2500ml 1523.0CNY Detail
Alfa Aesar (A14852)  Pyrrolidine, 99%    123-75-1 500ml 429.0CNY Detail
Alfa Aesar (A14852)  Pyrrolidine, 99%    123-75-1 100ml 223.0CNY Detail

123-75-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name pyrrolidine

1.2 Other means of identification

Product number -
Other names Tetrahydro pyrrole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:123-75-1 SDS

123-75-1Synthetic route

pyrrole
109-97-7

pyrrole

pyrrolidine
123-75-1

pyrrolidine

Conditions
ConditionsYield
With 5% Ru/MgO; hydrogen In tetrahydrofuran at 150℃; under 38002.6 Torr; for 0.7h;100%
With dichloro(μ-chloro)(μ-hydrido)bis(η-p-cymene)diruthenium(II); hydrogen In neat (no solvent) at 90℃; under 60006 Torr; for 40h;89%
With Cp*Rh(2-(2-pyridyl)phenyl)H; hydrogen In neat (no solvent) at 100℃; under 27361.8 Torr; for 48h; Catalytic behavior; Glovebox;74%
N-(methoxycarbonyl)pyrrolidine
56475-80-0

N-(methoxycarbonyl)pyrrolidine

pyrrolidine
123-75-1

pyrrolidine

Conditions
ConditionsYield
With tert-butylamine In methanol for 3h; Heating;100%
With methyllithium; lithium bromide In tetrahydrofuran at 0℃; for 1h;95%
1-(pyrrolidinyl)-2,4-dinitronaphthalene
78521-30-9

1-(pyrrolidinyl)-2,4-dinitronaphthalene

methylamine
74-89-5

methylamine

A

pyrrolidine
123-75-1

pyrrolidine

B

1-(Methylamino)-2,4-dinitronaphthalene
39139-78-1

1-(Methylamino)-2,4-dinitronaphthalene

Conditions
ConditionsYield
In water at 30℃; for 1h;A n/a
B 98%
2-pyrrolidinon
616-45-5

2-pyrrolidinon

pyrrolidine
123-75-1

pyrrolidine

Conditions
ConditionsYield
With methanesulfonic acid; ruthenium(1,1,1-tris(di(3,5-dimethylphenyl)phosphinomethyl)ethane)(η4-trimethylenemethane); hydrogen In tetrahydrofuran at 160℃; under 75007.5 Torr; for 16h; Autoclave; Schlenk technique;98%
With tris(pentafluorophenyl)borate; C21H35BrMnNO2P2; potassium tert-butylate; hydrogen In m-xylene at 150℃; under 37503.8 Torr; for 72h;81%
With borane-ammonia complex; boron trifluoride diethyl etherate; tris(pentafluorophenyl)borate In 1,2-dichloro-ethane at 60℃; for 16h;77%
1,4-diaminobutane
110-60-1

1,4-diaminobutane

pyrrolidine
123-75-1

pyrrolidine

Conditions
ConditionsYield
HZSM-5(280) zeolite In water at 300℃; Cyclization;97%
tris(triphenylphosphine)ruthenium(II) chloride In diphenylether at 180℃; for 5h; Product distribution; other α,ω-aliphatic diamines;90%
With carbonylchloro[4,5-bis(diisopropylphosphinomethyl)acridine]hydridoruthenium(II) In 1,4-dioxane; water at 100℃; for 22h; Schlenk technique; Inert atmosphere;88%
pyrrolidine-1-carboxylic acid prop-2-ynyl ester
123477-57-6

pyrrolidine-1-carboxylic acid prop-2-ynyl ester

pyrrolidine
123-75-1

pyrrolidine

Conditions
ConditionsYield
With benzyltriethylammonium tetrathiomolybdate In acetonitrile at 20℃; for 2.5h;97%
Butane-1,4-diol
110-63-4

Butane-1,4-diol

pyrrolidine
123-75-1

pyrrolidine

Conditions
ConditionsYield
With ammonia; hydrogen; CuO/ZnO/Al2O3 at 220℃; under 26252.1 Torr;94%
With aluminum oxide; ammonia at 400℃;
With aluminum oxide; ammonia at 325℃;
ethyl pyrrolidine-1-carboxylate
5470-26-8

ethyl pyrrolidine-1-carboxylate

pyrrolidine
123-75-1

pyrrolidine

Conditions
ConditionsYield
With methyllithium; lithium bromide In tetrahydrofuran at 0℃; for 1h;94%
1-(9-fluorenylmethoxycarbonyl)pyrrolidine
142653-70-1

1-(9-fluorenylmethoxycarbonyl)pyrrolidine

pyrrolidine
123-75-1

pyrrolidine

Conditions
ConditionsYield
With triethylamine; 1-butyl-3-methylimidazolium Tetrafluoroborate In neat (no solvent) at 25℃; for 0.0666667h; Green chemistry;93%
N-benzylpyrrolidine
29897-82-3

N-benzylpyrrolidine

pyrrolidine
123-75-1

pyrrolidine

Conditions
ConditionsYield
With 9,10-Dicyanoanthracene In water; acetonitrile Irradiation;90%
4-Aminobutanol
13325-10-5

4-Aminobutanol

pyrrolidine
123-75-1

pyrrolidine

Conditions
ConditionsYield
With carbonylchloro[4,5-bis(diisopropylphosphinomethyl)acridine]hydridoruthenium(II) In 1,4-dioxane; water at 100℃; for 10h; Schlenk technique; Inert atmosphere;88%
With aluminum oxide; nitrogen at 400℃;
dihydridotetrakis(triphenylphosphine)ruthenium In neat (no solvent) at 155℃; for 24h;79 % Chromat.
C13H14BrN3O3

C13H14BrN3O3

A

pyrrolidine
123-75-1

pyrrolidine

B

5-Bromo-7-nitroindoline
80166-90-1

5-Bromo-7-nitroindoline

Conditions
ConditionsYield
With water In 1,4-dioxane; dichloromethane at 20℃; for 12h; UV-irradiation;A 88%
B n/a
tert-butyl pyrrolidine-1-carboxylate
86953-79-9

tert-butyl pyrrolidine-1-carboxylate

A

pyrrolidine
123-75-1

pyrrolidine

B

isobutene
115-11-7

isobutene

Conditions
ConditionsYield
With methanesulfonic acid In tetrahydrofuran at 45℃; Solvent; Temperature;A 83%
B n/a
With cyclohexene at 260.9℃; under 44 Torr; Kinetics; Further Variations:; Pressures; Temperatures;
N-nitrosopyrrolidine
930-55-2

N-nitrosopyrrolidine

pyrrolidine
123-75-1

pyrrolidine

Conditions
ConditionsYield
With isocyanate de chlorosulfonyle In diethyl ether for 10h; Ambient temperature;78%
methanol
67-56-1

methanol

N-(4-methylphenylsulfinyl)pyrrolidine
57671-12-2

N-(4-methylphenylsulfinyl)pyrrolidine

A

pyrrolidine
123-75-1

pyrrolidine

B

methyl p-toluene sulfinate
672-78-6

methyl p-toluene sulfinate

Conditions
ConditionsYield
With tetraethylammonium tosylate Electrochemical reaction; reticulated vitreous carbon anode; Pt cathode;A n/a
B 75%
C20H22NO2S(1+)*BF4(1-)

C20H22NO2S(1+)*BF4(1-)

A

pyrrolidine
123-75-1

pyrrolidine

B

[(methylthio)methyl]-benzene
766-92-7

[(methylthio)methyl]-benzene

C

N1,N2-dimethylphthalamide
19532-98-0

N1,N2-dimethylphthalamide

Conditions
ConditionsYield
With methylamine at 30℃; for 20h;A n/a
B 74%
C n/a
Butane-1,4-diol
110-63-4

Butane-1,4-diol

A

pyrrolidine
123-75-1

pyrrolidine

B

1-butylpyrrolidine
767-10-2

1-butylpyrrolidine

C

4-(pyrrolidin-1-yl)butan-1-ol
93264-47-2

4-(pyrrolidin-1-yl)butan-1-ol

D

1,4-di-(1-pyrrolidinyl)butane
41726-75-4

1,4-di-(1-pyrrolidinyl)butane

E

N-butylamine
109-73-9

N-butylamine

Conditions
ConditionsYield
With ammonia; hydrogen; iron RFC at 260℃; Product distribution; Mechanism; other temp. (280, 300, 310 deg C);A 71%
B 12%
C n/a
D n/a
E 9%
C17H22NO2S(1+)*BF4(1-)

C17H22NO2S(1+)*BF4(1-)

A

pyrrolidine
123-75-1

pyrrolidine

B

sulfure de pentamethylene
1613-51-0

sulfure de pentamethylene

C

N1,N2-dimethylphthalamide
19532-98-0

N1,N2-dimethylphthalamide

Conditions
ConditionsYield
With methylamine at 30℃; for 20h;A n/a
B 71%
C n/a
C20H30NO2S(1+)*BF4(1-)

C20H30NO2S(1+)*BF4(1-)

A

pyrrolidine
123-75-1

pyrrolidine

B

Dibutyl sulfide
544-40-1

Dibutyl sulfide

C

N1,N2-dimethylphthalamide
19532-98-0

N1,N2-dimethylphthalamide

Conditions
ConditionsYield
With methylamine at 30℃; for 20h;A n/a
B 70%
C n/a
C6H12NO(1+)*CH3O4S(1-)
73722-93-7

C6H12NO(1+)*CH3O4S(1-)

A

pyrrolidine
123-75-1

pyrrolidine

B

1-pyrrolidinecarboxaldehyde
3760-54-1

1-pyrrolidinecarboxaldehyde

C

N-nitrosopyrrolidine
930-55-2

N-nitrosopyrrolidine

Conditions
ConditionsYield
With sodium nitrite In waterA n/a
B 70%
C n/a
pyrrolidine
123-75-1

pyrrolidine

succinic acid anhydride
108-30-5

succinic acid anhydride

4-oxo-4-(1-pyrrolidinyl)butanoic acid
69338-35-8

4-oxo-4-(1-pyrrolidinyl)butanoic acid

Conditions
ConditionsYield
In acetonitrile at 20℃;100%
In chloroform for 1h; Heating;83%
With diethyl ether
Reflux;
In toluene for 2.5h; Reflux;
pyrrolidine
123-75-1

pyrrolidine

Nonanoyl chloride
764-85-2

Nonanoyl chloride

1-(pyrrolidin-1-yl)nonan-1-one
20308-70-7

1-(pyrrolidin-1-yl)nonan-1-one

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;100%
With diethyl ether; triethylamine
pyrrolidine
123-75-1

pyrrolidine

undec-10-enoyl chloride
38460-95-6

undec-10-enoyl chloride

1-(pyrrolidin-1-yl)undec-10-en-1-one
95018-99-8

1-(pyrrolidin-1-yl)undec-10-en-1-one

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;100%
With triethylamine In dichloromethane at 0 - 23℃; for 14h;100%
With triethylamine In dichloromethane at 0 - 23℃; for 14h;100%
pyrrolidine
123-75-1

pyrrolidine

Cholest-4-en-3-one
601-57-0

Cholest-4-en-3-one

1-cholesta-3,5-dien-3-yl-pyrrolidine
2309-31-1

1-cholesta-3,5-dien-3-yl-pyrrolidine

Conditions
ConditionsYield
In benzene for 24h; Heating;100%
In benzene100%
93%
pyrrolidine
123-75-1

pyrrolidine

cyclohexane-1,2-epoxide
286-20-4

cyclohexane-1,2-epoxide

(+/-)-trans-[2-(pyrrolidinyl)]cyclohexanol
69420-67-3

(+/-)-trans-[2-(pyrrolidinyl)]cyclohexanol

Conditions
ConditionsYield
for 114h; Heating;100%
With lithium bromide at 20℃; for 2h;100%
With zinc(II) perchlorate hexahydrate at 80℃; for 1h;100%
pyrrolidine
123-75-1

pyrrolidine

cyclohexanone
108-94-1

cyclohexanone

1-(1-Cyclohexen-1-yl)pyrrolidine
1125-99-1

1-(1-Cyclohexen-1-yl)pyrrolidine

Conditions
ConditionsYield
In toluene for 18h; Molecular sieve; Dean-Stark trap; Heating / reflux;100%
With sulfuric acid In toluene Dean-Stark; Reflux;99%
With K-10 Montmorillonite clay In toluene for 2.5h; Heating;95%
pyrrolidine
123-75-1

pyrrolidine

4-chlorobenzonitrile
100-00-5

4-chlorobenzonitrile

1-(4-nitro-phenyl)-pyrrolidine
10220-22-1

1-(4-nitro-phenyl)-pyrrolidine

Conditions
ConditionsYield
In tetrahydrofuran at 50℃; under 4500360 Torr; for 20h;100%
In tetrahydrofuran at 50℃; under 6000 Torr; for 2h; Product distribution; other pressure;100%
at 108℃; for 2h; Neat (no solvent);98%
pyrrolidine
123-75-1

pyrrolidine

acrylic acid methyl ester
292638-85-8

acrylic acid methyl ester

methyl 3-(pyrrolidin-1-yl)propanoate
22041-21-0

methyl 3-(pyrrolidin-1-yl)propanoate

Conditions
ConditionsYield
With zirconium(IV) chloride In dichloromethane at 20℃; for 0.75h; Michael addition;100%
With silica-supported aluminum chloride at 60℃; for 2h; Michael addition; Neat (no solvent);100%
In dichloromethane at 0 - 20℃; for 2h;100%
pyrrolidine
123-75-1

pyrrolidine

chloroacetyl chloride
79-04-9

chloroacetyl chloride

chloroacetic acid pyrrolidide
20266-00-6

chloroacetic acid pyrrolidide

Conditions
ConditionsYield
In acetone at 20℃;100%
In tetrahydrofuran at 0 - 20℃; for 3.5h;99%
In tetrahydrofuran at 20℃; for 12h; Acylation;98%
pyrrolidine
123-75-1

pyrrolidine

phenylacetyl chloride
103-80-0

phenylacetyl chloride

phenylacetylpyrrolidine
3389-53-5

phenylacetylpyrrolidine

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃;100%
With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;100%
With triethylamine In dichloromethane at 20℃;92%
pyrrolidine
123-75-1

pyrrolidine

1-nitropyrrolidine
3760-55-2

1-nitropyrrolidine

Conditions
ConditionsYield
With 2-(trifluoromethyl)-2-propyl nitrate at 50℃; for 168h;100%
With nitronium trifluoromethanesulfonate In dichloromethane at -20℃; for 1h;43%
With tetrachloromethane; dinitrogen pentoxide
With butyl nitrate; ethylmagnesium bromide 1.) benzene, 15 min, 2.) benzene, 0.5 h; Yield given. Multistep reaction;
pyrrolidine
123-75-1

pyrrolidine

Cyclopentene oxide
285-67-6

Cyclopentene oxide

(+/-)-trans-(1-pyrrolidinyl)cyclopentan-2-ol
32635-39-5

(+/-)-trans-(1-pyrrolidinyl)cyclopentan-2-ol

Conditions
ConditionsYield
bismuth(lll) trifluoromethanesulfonate at 160℃; for 0.25h; microwave irradiation;100%
With triethylaluminum 1.) toluene, CH2Cl2, 25-30 deg C, 30 min, 2.) room temperature; Yield given. Multistep reaction;
In water
With potassium carbonate
In ethanol at 80℃; for 18h; Inert atmosphere;
pyrrolidine
123-75-1

pyrrolidine

4-butanolide
96-48-0

4-butanolide

4-hydroxy-1-(pyrrolidin-1-yl)butan-1-one
73200-24-5

4-hydroxy-1-(pyrrolidin-1-yl)butan-1-one

Conditions
ConditionsYield
With triethylamine Inert atmosphere; Reflux;100%
With triethylamine for 16h; Reflux;94%
In benzene for 3h; Heating;90%
pyrrolidine
123-75-1

pyrrolidine

3,4,5,6-tetrahydro-2H-pyran-2-one
542-28-9

3,4,5,6-tetrahydro-2H-pyran-2-one

5-hydroxy-1-(pyrrolidin-1-yl)pentan-1-one
73200-35-8

5-hydroxy-1-(pyrrolidin-1-yl)pentan-1-one

Conditions
ConditionsYield
With triethylamine Inert atmosphere; Reflux;100%
In benzene82%
pyrrolidine
123-75-1

pyrrolidine

phenylacetic acid
103-82-2

phenylacetic acid

phenylacetylpyrrolidine
3389-53-5

phenylacetylpyrrolidine

Conditions
ConditionsYield
Stage #1: phenylacetic acid With 4-iodofuran-3-yl-boronic acid In dichloromethane for 0.166667h; Molecular sieve 4Å;
Stage #2: pyrrolidine In dichloromethane at 25℃; for 6h; Product distribution / selectivity;
100%
With 4 A molecular sieve at 150℃; for 2h;98%
With tetramethylorthosilicate In toluene at 110℃; for 1h; Inert atmosphere;98%
pyrrolidine
123-75-1

pyrrolidine

p-nitrobenzene iodide
636-98-6

p-nitrobenzene iodide

1-(4-nitro-phenyl)-pyrrolidine
10220-22-1

1-(4-nitro-phenyl)-pyrrolidine

Conditions
ConditionsYield
In tetrahydrofuran at 50℃; under 9000720 Torr; for 20h;100%
With copper(l) iodide; 1-(5,6,7,8-tetrahydroquinolin-8-yl)ethan-1-one; caesium carbonate In N,N-dimethyl-formamide at 25℃; for 24h; Ullmann condensation; Inert atmosphere;95%
With copper(l) iodide In N,N-dimethyl acetamide at 130℃; for 24h;95%
pyrrolidine
123-75-1

pyrrolidine

1-Chlor-4-phenyl-pyridazino<4,5-d>pyridazin
72553-83-4

1-Chlor-4-phenyl-pyridazino<4,5-d>pyridazin

1-Pyrrolidino-4-phenyl-pyridazino<4,5-d>pyridazin
83490-50-0

1-Pyrrolidino-4-phenyl-pyridazino<4,5-d>pyridazin

Conditions
ConditionsYield
for 3h; Heating;100%
pyrrolidine
123-75-1

pyrrolidine

6'-chloro-1,3,1',3'-tetramethyl-3H,1'H-[4,5']bipyrimidinyl-2,6,2',4'-tetraone
74151-83-0

6'-chloro-1,3,1',3'-tetramethyl-3H,1'H-[4,5']bipyrimidinyl-2,6,2',4'-tetraone

1,3,1',3'-Tetramethyl-6-pyrrolidin-1-yl-1H,1'H-[5,5']bipyrimidinyl-2,4,2',4'-tetraone

1,3,1',3'-Tetramethyl-6-pyrrolidin-1-yl-1H,1'H-[5,5']bipyrimidinyl-2,4,2',4'-tetraone

Conditions
ConditionsYield
100%
pyrrolidine
123-75-1

pyrrolidine

cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

2-Methylbutyraldehyde
96-17-3, 57456-98-1

2-Methylbutyraldehyde

2,2-Dimethyl-5-(2-methyl-1-pyrrolidin-1-yl-butyl)-[1,3]dioxane-4,6-dione

2,2-Dimethyl-5-(2-methyl-1-pyrrolidin-1-yl-butyl)-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In diethyl ether for 0.166667h;100%
pyrrolidine
123-75-1

pyrrolidine

cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

d,l-2-ethylhexanal
123-05-7

d,l-2-ethylhexanal

5-(2-Ethyl-1-pyrrolidin-1-yl-hexyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione
93498-12-5

5-(2-Ethyl-1-pyrrolidin-1-yl-hexyl)-2,2-dimethyl-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In diethyl ether for 0.166667h;100%
pyrrolidine
123-75-1

pyrrolidine

cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

benzaldehyde
100-52-7

benzaldehyde

2,2-Dimethyl-5-(phenyl-pyrrolidin-1-yl-methyl)-[1,3]dioxane-4,6-dione
93498-11-4

2,2-Dimethyl-5-(phenyl-pyrrolidin-1-yl-methyl)-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In diethyl ether for 0.166667h;100%
pyrrolidine
123-75-1

pyrrolidine

cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

propionaldehyde
123-38-6

propionaldehyde

2,2-Dimethyl-5-(1-pyrrolidin-1-yl-propyl)-[1,3]dioxane-4,6-dione
93498-07-8

2,2-Dimethyl-5-(1-pyrrolidin-1-yl-propyl)-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In diethyl ether for 0.166667h;100%
pyrrolidine
123-75-1

pyrrolidine

cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

butyraldehyde
123-72-8

butyraldehyde

2,2-Dimethyl-5-(1-pyrrolidin-1-yl-butyl)-[1,3]dioxane-4,6-dione
93498-08-9

2,2-Dimethyl-5-(1-pyrrolidin-1-yl-butyl)-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In diethyl ether for 0.166667h;100%
pyrrolidine
123-75-1

pyrrolidine

cycl-isopropylidene malonate
2033-24-1

cycl-isopropylidene malonate

isobutyraldehyde
78-84-2

isobutyraldehyde

2,2-Dimethyl-5-(2-methyl-1-pyrrolidin-1-yl-propyl)-[1,3]dioxane-4,6-dione
93498-09-0

2,2-Dimethyl-5-(2-methyl-1-pyrrolidin-1-yl-propyl)-[1,3]dioxane-4,6-dione

Conditions
ConditionsYield
In diethyl ether for 0.166667h;100%
pyrrolidine
123-75-1

pyrrolidine

formaldehyd
50-00-0

formaldehyd

1-acetyl-3-(2-propynyl)-2-imidazolidone
142238-04-8

1-acetyl-3-(2-propynyl)-2-imidazolidone

1-Acetyl-3-(4-pyrrolidin-1-yl-but-2-ynyl)-imidazolidin-2-one
142237-98-7

1-Acetyl-3-(4-pyrrolidin-1-yl-but-2-ynyl)-imidazolidin-2-one

Conditions
ConditionsYield
With acetic acid; copper(l) chloride In 1,4-dioxane at 50℃; for 4h;100%
pyrrolidine
123-75-1

pyrrolidine

4,5-dihydro-5-phenyl-2(3H)-furanone
1008-76-0

4,5-dihydro-5-phenyl-2(3H)-furanone

4-hydroxy-4-phenyl-1-(pyrrolidine-1-yl)butan-1-one
99802-88-7

4-hydroxy-4-phenyl-1-(pyrrolidine-1-yl)butan-1-one

Conditions
ConditionsYield
With triethylamine Reflux; Inert atmosphere;100%
With triethylamine for 72h; Schlenk technique; Reflux;97%
In water for 4h; Heating;90%
pyrrolidine
123-75-1

pyrrolidine

5,6,9,10,11,11a-Hexahydro-2,3-dimethoxy-8,10-dioxo-8H-benzoquinolizine
5911-65-9

5,6,9,10,11,11a-Hexahydro-2,3-dimethoxy-8,10-dioxo-8H-benzoquinolizine

5,6,11,11a-Tetrahydro-2,3-dimethoxy-8-oxo-10-(1-pyrrolidinyl)-8H-benzoquinolizine
85222-89-5

5,6,11,11a-Tetrahydro-2,3-dimethoxy-8-oxo-10-(1-pyrrolidinyl)-8H-benzoquinolizine

Conditions
ConditionsYield
In benzene for 1h; Heating;100%
pyrrolidine
123-75-1

pyrrolidine

7α,11β-eudesm-4-en-12,6α-olide
18410-00-9

7α,11β-eudesm-4-en-12,6α-olide

(S)-2-((1S,2S,4aR)-1-Hydroxy-4a,8-dimethyl-1,2,3,4,4a,5,6,7-octahydro-naphthalen-2-yl)-1-pyrrolidin-1-yl-propan-1-one

(S)-2-((1S,2S,4aR)-1-Hydroxy-4a,8-dimethyl-1,2,3,4,4a,5,6,7-octahydro-naphthalen-2-yl)-1-pyrrolidin-1-yl-propan-1-one

Conditions
ConditionsYield
In benzene for 30h; Ambient temperature;100%
pyrrolidine
123-75-1

pyrrolidine

(S)-2-((1S,2S,4aR)-1-Hydroxy-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-2-yl)-1-pyrrolidin-1-yl-propan-1-one

(S)-2-((1S,2S,4aR)-1-Hydroxy-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-2-yl)-1-pyrrolidin-1-yl-propan-1-one

Conditions
ConditionsYield
In benzene for 18h; Ambient temperature;100%

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