111721-75-6

Basic information

• Product Name: 2-Bromo-3-fluoroaniline
• Synonyms: 2-BROMO-3-FLUOROANILINE;2-BROMO-3-FLUORO-PHENYLAMINE;2-Bromo-3-fluoroaniline 98%;Bromo-3-fluoroaniline
• CAS NO: 111721-75-6
• Molecular Formula: C₆H₅BrFN
• Molecular Weight: 190.01
• Product Categories: Anilines, Aromatic Amines and Nitro Compounds;Aniline;Fluorine series;Pyridines
• Mol File: 111721-75-6.mol

Chemical Properties

• Melting Point: 32-34 °C
• Boiling Point: 229.845 °C at 760 mmHg
• Flash Point: 94°(201°F)
• Appearance: Off-white/Crystalline
• Density: 1.670
• Vapor Pressure: 0.068mmHg at 25°C
• Refractive Index: 1.5830
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 1.52±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Bromo-3-fluoroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-3-fluoroaniline(111721-75-6)
• EPA Substance Registry System: 2-Bromo-3-fluoroaniline(111721-75-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36-36/37/38-20/21/22
• Safety Statements: 9-26-36/37-60
• RIDADR: 2811
• HazardClass: 6.1
• Hazardous Substances Data: 111721-75-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-3-fluoroaniline is used as a pharmaceutical intermediate for the synthesis of a variety of drugs. Its unique chemical structure allows it to be a key component in the development of medications that target specific biological pathways or receptors, contributing to the creation of effective treatments for various health conditions.

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 27, p. 2151, 1990 DOI: 10.1002/jhet.5570270755

InChI:InChI=1/C6H5BrFN/c7-6-4(8)2-1-3-5(6)9/h1-3H,9H2

Upstream product

• 132715-70-9 2-Bromo-3-fluorobenzamide 
• 118313-91-0 N-(2-bromo-3-fluorophenyl)-2,2,2-trifluoroacetamide 
• 372-19-0 meta-fluoroaniline 
• 317-20-4 7-fluoro-1H-indole-2,3-dione 
• 348-54-9 2-Fluoroaniline 
• 35980-21-3 2,2,2-trifluoro-N-(3-fluorophenyl)acetamide 
• 349-24-6 N-(2-Fluorophenyl)-2-hydroxyiminoacetamide 
• 825-22-9 3-fluoroanthranilic acid 
• 1000339-91-2 2-bromo-3-fluorobenzoyl chloride 
• 132715-69-6 2-bromo-3-fluoro-benzoic acid 
• 16582-88-0 N-(2,3,4,5-tetrafluorophenyl)acetamide 
• 59255-94-6 2-bromo-3-fluoronitrobenzene 
• 863870-75-1 O-2-bromo-3-fluorophenyl N,N-diethylcarbamate 
• 1287791-64-3 2-(2-bromo-3-fluorophenoxy)-2-methylpropanamide 

Downstream Products

• 1001322-85-5 N-(2-bromo-3-fluorophenyl)cinnamamide 
• 276702-10-4 N-[4-chloro-2-hydroxy-3-(aminosulfonyl)phenyl]-N'(2-bromo-3-fluorophenyl)-urea 
• 952664-87-8 N-(2-bromo-3-fluorophenyl)butyramide 
• 1268518-43-9 2-(2-bromo-3-fluorophenyl)hydrazono-N-cyclopropyl-2-cyanoacetamide 
• 952664-88-9 N-(2-(3,3-dimethylbut-1-ynyl)-3-fluorophenyl)butyramide 
• 952664-89-0 2-tert-butyl-4-fluoro-1H-indole 
• 952664-90-3 2-tert-butyl-4-fluoro-5-nitro-1H-indole 
• 1313227-96-1 N-(2-bromo-3-fluorophenyl)acetamide 
• 1384081-81-5 4-fluoro-3,3-dimethyl-2,3-dihydro-1H-indole 
• 1384082-39-6 N-(2-bromo-3-fluorophenyl)-N-(2-methylallyl)acetamide 

Relevant articles and documents

Preparation method of 1-fluoro-2-bromo-iodobenzene

The invention provides a preparation method of 1-fluoro-2-bromo-iodobenzene. The method comprises the steps that 1-fluorine-2-amidogen-3-nitrobenzene is used as a raw material, 1-fluorine-2-bromine-3-nitrobenzene is obtained through a diazotization and bromination reaction, 1-fluoro-2-bromo-aminobenzene is obtained through a following reduction reaction, and then 1-fluoro-2-bromo-iodobenzene is obtained through a diazotization and iodination reaction. According to the preparation method, under the acidic condition, 1-fluoro-2-bromo-aminobenzene and sodium nitrite react in a solvent, hydrogen iodide or iodate is added to the mixed solution, and 1-fluoro-2-bromo-iodobenzene is obtained through a reaction. The preparation method of 1-fluoro-2-bromo-iodobenzene is high in safety, mild in reaction condition, low in cost, easy to operate and industrialize and high in utilization rate of iodine.

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

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Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

Modulators of ATP-binding cassette transporters

Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

Synthetic Entries to 6-Fluoro-7-substituted Indole Derivatives

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Substituted 1,3,4,9-tetrahydropyrano [3,4-B]indole-1-acetic acids

Indole derivatives characterized by having a 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid nucleus bearing a substituent in position 1-, 4-, 5-, 6-, 7- and 8- are disclosed. The derivatives are useful anti-inflammatory and analgesic agents and methods for their preparation and use are also disclosed.