- Easy access to CF2-containing molecules based on the reaction of 2,2,3,3-tetrafluorooxetane with various nucleophiles
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2,2,3,3-Tetrafluorooxetane reacted easily with organolithium reagents to give 1,1,3-trisubstituted 2,2-difluoropropan-1-ols in good to excellent yields. On the other hand, the reaction with Grignard reagent led to 3-bromo-1,1-disubstituted 2,2-difluoropro
- Yamada, Shigeyuki,Kato, Masahiro,Komori, Yudai,Konno, Tsutomu,Ishihara, Takashi
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experimental part
p. 5493 - 5502
(2011/08/10)
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- Synthese von α-Fluoracrylsaeure und Derivaten
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Three new routes to derivatives of α-fluoracrylic acid, including a laboratory synthesis and a large-scale method, are reported.The processes are (i) addition of elementary fluorine to acrylic esters and subsequent elimination of HF; (ii) addition of difluorocarbene to isopropenyl methyl ether, oxidation via ring opening and dehalogenation; and (iii) "nitrofluorination" of 2,3-dichloropropene, hydrolysis and dechlorination.
- Gassen, K.-R.,Bielefeldt, D.,Marhold, A.,Andres P.
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p. 149 - 162
(2007/10/02)
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- N-Aryl 3-Halogenated Azetidin-2-ones and Benzocarbacephems, Inhibitors of β-Lactamases
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N-(3-Carboxy-6-methylphenyl)-3-fluoroazetidin-2-one and a series of related N-aryl-3-halo- and -3,3-dihaloazetidinones 3, in which the halo substituent is a fluorine or a bromine atom, were prepared, by using the Wasserman procedure of cyclization of β-br
- Joyeau, Roger,Molines, Huguette,Labia, Roger,Wakselman, Michel
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p. 370 - 374
(2007/10/02)
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