111873-49-5

Upstream product

• 38788-38-4 dibutyl telluride 
• 70-11-1 α-bromoacetophenone 

Downstream Products

• 119405-04-8 7-Benzoyl-2-oxo-norcarane 
• 24721-26-4 4-chlorochalcone 
• 428818-96-6 (BrBu₂Te)2O 
• 22966-09-2 (2E)-3-(4-bromophenyl)-1-phenylprop-2-en-1-one 
• 2960-55-6 (E)-3-(4-nitrophenyl)-1-phenylprop-2-en-1-one 
• 614-48-2 (E)-3-nitrochalcone 

Relevant academic research and scientific papers

Wittig-type olefination catalyzed by PEG-telluride

Soluble poly(ethylene glycol) (PEG)-supported telluride 2 was designed and synthesized for catalytic Wittig-type reactions. It was found that the catalytic loading could be reduced from 20 to 2 mol % by the introduction of PEG (even to 0.5 mol % when some telluride salts were used as the catalyst). Under the catalytic reaction conditions, a wide variety of aldehydes with different structures could react with bromoacetate to afford β-substituted or α,β-disubstituted unsaturated esters in high yields with excellent E-stereoselectivity. The modified process, by using sodium bisulfite instead of triphenyl phosphite, represented a very simple product isolation procedure. The roles of PEG for promoting the ylide formation and stabilizing the catalytic species were disclosed. The mechanism was also studied.

Unexpected catalyst for Wittig-type and dehalogenation reactions

A novel catalyst 2 for Wittig-type and dehalogenation reactions was developed. In the presence of triphenyl phosphite, a wide variety of aldehydes could react with α-bromoacetates to afford α,β-unsaturated esters or ketones in high yields with excellent E-stereoselectivity when 1-2 mol % of compound 2 was used. Compound 2 was also an effective catalyst for reductive dehalogenation of α-bromocarbonyl compounds. The mechanisms for the above reactions were also proposed.